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公开(公告)号：US11793915B2
公开(公告)日：2023-10-24
申请号：US17493758
申请日：2021-10-04
CPC分类号： A61M1/1601 , A61M1/154 , A61M1/155 , A61M1/1561 , A61M1/1565 , A61M1/15625 , A61M1/16 , A61M1/1621 , A61M1/1654 , A61M1/1694 , A61M1/267 , A61M1/3401 , A61M1/341 , A61M1/3413 , A61M1/3424 , A61M1/365 , A61M1/3609 , A61M1/3621 , A61M1/3638 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , A61M1/3652 , A61M1/3672 , A61M1/36224 , A61M1/362261 , A61M1/362263 , A61M1/362265 , A61M1/362266 , A61M2205/07 , A61M2205/12 , A61M2205/123 , A61M2205/128 , A61M2205/15 , A61M2205/16 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/36 , A61M2205/505 , A61M2205/82 , A61M2205/8218 , A61M2205/8225 , Y10T137/87893
摘要： The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
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公开(公告)号：US12064540B2
公开(公告)日：2024-08-20
申请号：US18452516
申请日：2023-08-18
CPC分类号： A61M1/1601 , A61M1/154 , A61M1/155 , A61M1/15625 , A61M1/1565 , A61M1/16 , A61M1/1621 , A61M1/1654 , A61M1/1694 , A61M1/267 , A61M1/3401 , A61M1/341 , A61M1/3413 , A61M1/3424 , A61M1/3609 , A61M1/3621 , A61M1/36224 , A61M1/36225 , A61M1/362263 , A61M1/362265 , A61M1/362266 , A61M1/3623 , A61M1/3638 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3672 , A61M1/1561 , A61M1/362261 , A61M2205/07 , A61M2205/12 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/15 , A61M2205/16 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/36 , A61M2205/505 , A61M2205/82 , A61M2205/8218 , A61M2205/8225 , Y10T137/87893
摘要： The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
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3.发明公开公开(公告)号：US20230390474A1
公开(公告)日：2023-12-07
申请号：US18266467
申请日：2021-12-09
申请人： PLAS-FREE LTD
发明人： Zeev DVASHI , Nuha HIJAZI
CPC分类号： A61M1/3486 , A61M1/3496 , A61M1/3401 , B01J20/24 , B01J20/28016 , B01J20/289 , B01J20/3295 , B01J20/3212 , B01J20/3257 , B01J20/3219 , B01D15/22 , B01D15/3804
摘要： The present invention pertains to present invention relates to a device comprising conjugate/s, and uses thereof in depleting at least one amine, specifically ammonia from body fluids. The present disclosure further provides systems, apparatus, conjugates, plurality of conjugates, and methods. More specifically, the conjugate comprising a particle bonded to at least one linker comprising a chain of n carbon atoms covalently bonded to m carbonyl groups, and at least one trapping agent A covalently bonded to the mth carbonyl group, (Formula I) wherein, n is an integer within the range of 5 to 15, and m is an integer within the range of 5 to 10, wherein trapping agent A is characterized by having the ability to capture or bind amine. In some optional embodiments, the amine is at least one of methylamine, dimethylamine or trimethylamine. In some embodiments, the linker of the conjugate of the disclosed device comprises a straight chain alkane and m carbonyl groups
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公开(公告)号：US20230338632A1
公开(公告)日：2023-10-26
申请号：US18346174
申请日：2023-06-30
IPC分类号： A61M1/34 , G06F11/30 , A61M5/172 , A61M1/14 , G06F9/00 , A61M1/16 , A61M1/36 , G16H20/40 , G16H40/63 , G16H40/60 , A61M1/26
CPC分类号： A61M1/1601 , A61M1/14 , A61M1/15 , A61M1/154 , A61M1/155 , A61M1/1561 , A61M1/15625 , A61M1/1565 , A61M1/1566 , A61M1/16 , A61M1/1621 , A61M1/1635 , A61M1/1694 , A61M1/267 , A61M1/3401 , A61M1/341 , A61M1/3462 , A61M1/3622 , A61M1/362223 , A61M1/362227 , A61M1/36225 , A61M1/362263 , A61M1/362265 , A61M1/362266 , A61M1/3626 , A61M1/3644 , A61M1/3652 , A61M1/3672 , A61M5/172 , G06F9/00 , G06F11/30 , G06F11/3089 , G16H20/40 , G16H40/60 , G16H40/63 , A61M1/1613 , A61M1/1619 , A61M1/1696 , A61M1/3427 , A61M1/3441 , A61M1/3465 , A61M1/3609 , A61M1/362261 , A61M1/3646 , A61M1/365 , A61M2205/12 , A61M2205/123 , A61M2205/128 , A61M2205/15 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/502 , Y10T137/87893
摘要： Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.
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公开(公告)号：US20240216595A1
公开(公告)日：2024-07-04
申请号：US18558591
申请日：2022-05-03
发明人： Shen Ren , Dayong Gao , Ye Jin
CPC分类号： A61M1/1696 , A61M1/3401 , A61M1/3649 , A61M2205/3331 , A61M2205/3368
摘要： A portable hemopurification system can remove one or more uremic toxins from blood of a patient. The hemopurification system includes a dialyzer with a dialyzing membrane. Blood from a patient is provided to the dialyzer on one side of the dialyzing membrane, and a negative-pressure pump applies negative pressure on the opposite side of the dialyzing membrane to provide ultrafiltration of uremic toxins from the blood. The system includes a replacement fluid line to deliver replacement fluid to the blood. The system includes load cells to measure the replacement fluid flow, effluent flow, and returned blood flow. The systems uses the fluid weights for the control of pumps to provide stable flow through the system.
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公开(公告)号：US11931492B2
公开(公告)日：2024-03-19
申请号：US17363554
申请日：2021-06-30
发明人： Michael E. Hogard , Donald D. Busby , Robert W. Childers , Yuanpang Samuel Ding , Katherine M. Holian , Mark E. Jablonski , Thomas D. Kelly , Shincy J. Maliekkal , Rodolfo G. Roger , Donald A. Smith , Atif M. Yardimci , Ying-Cheng Lo
CPC分类号： A61M1/14 , A61M1/1522 , A61M1/153 , A61M1/154 , A61M1/155 , A61M1/1561 , A61M1/15625 , A61M1/15632 , A61M1/1565 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1635 , A61M1/166 , A61M1/1696 , A61M1/28 , A61M1/284 , A61M1/288 , A61M1/3401 , A61M1/341 , A61M1/3413 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3444 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/362223 , A61M1/36224 , A61M1/362261 , A61M1/362262 , A61M1/362264 , A61M1/362265 , A61M2205/12 , A61M2205/3334
摘要： A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
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公开(公告)号：US20230285650A1
公开(公告)日：2023-09-14
申请号：US18117035
申请日：2023-03-03
申请人： Terumo BCT, Inc.
发明人： Tanner J. LADTKOW , Davis BENZ , Mark E. HILLAM
CPC分类号： A61M1/3401 , A61M1/3693 , A61M1/3496 , A61M2202/0415
摘要： A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.
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公开(公告)号：US20240325616A1
公开(公告)日：2024-10-03
申请号：US18618801
申请日：2024-03-27
申请人： Fenwal, Inc.
发明人： Thomas Gniadek
IPC分类号： A61M1/34 , A61K31/194 , A61K35/14 , A61M1/36
CPC分类号： A61M1/3403 , A61K31/194 , A61K35/14 , A61M1/3401 , A61M1/3496 , A61M1/3693 , A61M2205/3303 , A61M2205/3334
摘要： Methods and systems for performing an apheresis procedure with a reduced risk of citrate reaction occurrences are described. The volume of body water in the apheresis subject is used to predict the likelihood of a citrate reaction during infusion of a blood component to the subject and allows for establishing and maintaining an optimal flow rate of the infused blood component.
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公开(公告)号：US20230398274A1
公开(公告)日：2023-12-14
申请号：US18452516
申请日：2023-08-18
CPC分类号： A61M1/1601 , A61M1/1694 , A61M1/3643 , A61M1/3646 , A61M1/3649 , A61M1/3652 , A61M1/365 , A61M1/16 , A61M1/1654 , A61M1/3621 , A61M1/3644 , A61M1/3609 , A61M1/154 , A61M1/3401 , A61M1/341 , A61M1/155 , A61M1/362265 , A61M1/362263 , A61M1/362266 , A61M1/15625 , A61M1/1565 , A61M1/36224 , A61M1/3623 , A61M1/36225 , A61M1/1621 , A61M1/267 , A61M1/3424 , A61M1/3638 , A61M1/3413 , A61M1/3672 , Y10T137/87893 , A61M2205/128 , A61M2205/123 , A61M2205/12 , A61M2205/3368 , A61M2205/3334 , A61M2205/505 , A61M2205/3324 , A61M2205/3317 , A61M2205/8218 , A61M2205/82 , A61M2205/07 , A61M2205/16 , A61M2205/8225 , A61M1/1561 , A61M1/362261 , A61M2205/15 , A61M2205/3331 , A61M2205/36
摘要： The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
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10.发明公开公开(公告)号：US20230149613A1
公开(公告)日：2023-05-18
申请号：US18002576
申请日：2021-06-28
发明人： James R. Matson
CPC分类号： A61M1/3401 , A61P37/06 , A61K35/17 , A61M2202/0445
摘要： The invention relates generally to methods of treating or reducing the risk of Cytokine Release Syndrome (CRS), treating or reducing the risk of Tumor Lysis Syndrome (TLS), or increasing drug exposure in a subject undergoing CAR T-cell therapy or chemotherapy. The methods comprise contacting blood from the subject with an extracorporeal membrane having a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory cytokines, other inflammatory molecules, or metabolites to pass through the pores and out of the blood that is returned back to the subject.
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