公开(公告)号：US20240319148A1

公开(公告)日：2024-09-26

申请号：US18607432

申请日：2024-03-16

申请人： SHIMADZU CORPORATION

发明人： Shinji TANAKA

IPC分类号： G01N30/60 ,  B01D15/14 ,  G01N30/16

CPC分类号： G01N30/606 ,  B01D15/14 ,  G01N30/16

摘要： A fluid port structure includes a tube and a cylindrical portion and receives injection of a fluid. The tube has sealability. A flow path through which the fluid flows is formed in the tube. In the cylindrical portion, a through hole that extends in an axial direction in which the fluid flows is formed. An upstream end portion of the tube is inserted into the through hole. An inner peripheral surface of the cylindrical portion has a tapered surface, and the more upstream a position on the tapered surface than a predetermined position in the axial direction, the larger a diameter of the portion of the through hole. The tube has a widening portion that widens along the tapered surface of the cylindrical portion in the upstream end portion.

公开(公告)号：US12013379B2

公开(公告)日：2024-06-18

申请号：US17716436

申请日：2022-04-08

申请人： Waters Technologies Corporation

发明人： Joshua A. Burnett ,  Marc E. Lemelin ,  Sylvain Gilles Cormier

IPC分类号： G01N30/18 ,  B01D15/14 ,  G01N30/24 ,  G01N30/02 ,  G01N35/10

CPC分类号： G01N30/18 ,  B01D15/14 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/185 ,  G01N35/1004

摘要： A seal pack of a sample manager of a liquid chromatography system having a plurality of wash flow pathways fluidically connected to a central pathway that accommodates a sample needle, wherein a first wash flow pathway is vertically offset from a second wash flow pathway, such that a wash solution flows axially along an exterior surface of the sample needle in a vertical direction to wash the sample needle when flowing from the first wash flow pathway to the vertically offset second wash flow pathway, is provided. Furthermore, an autosampler and associated methods are also provided.

公开(公告)号：US11998862B2

公开(公告)日：2024-06-04

申请号：US18179835

申请日：2023-03-07

申请人： Waters Technologies Corporation

发明人： Raymond P. Fisk ,  Timothy J. Becker ,  Mary Elizabeth Lame ,  Frank John Marszalkowski ,  Matthew A. Lauber

IPC分类号： B01L3/00 ,  B01D15/12 ,  B01D15/14 ,  B01D15/22 ,  B01D15/38 ,  B01D15/42 ,  B01L3/02

CPC分类号： B01D15/3809 ,  B01D15/12 ,  B01D15/14 ,  B01D15/22 ,  B01D15/424 ,  B01L3/5023 ,  B01L3/0275 ,  B01L3/5021 ,  B01L2200/0631 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2400/0409 ,  B01L2400/0433

摘要： The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.

公开(公告)号：US20240123370A1

公开(公告)日：2024-04-18

申请号：US18177365

申请日：2023-03-02

申请人： Hyundai Motor Company ,  Kia Corporation

发明人： Kyeong Jun BAEK ,  Sun Ae Park ,  Hun Woo Park ,  Hyung Geun Cho ,  Young Sang Cho ,  Sang Pil Byun

IPC分类号： B01D15/14 ,  B01D15/22 ,  B01D15/36 ,  F16K27/02 ,  F16K31/524

CPC分类号： B01D15/14 ,  B01D15/22 ,  B01D15/361 ,  F16K27/02 ,  F16K31/52408 ,  H01M8/04044

摘要： An ion filter for circulating coolant in a fuel cell stack of a fuel cell vehicle includes a housing including an inlet configured so that a fluid is introduced and an outlet configured so that the fluid is discharged, a filter element accommodated in the housing to filter the fluid, a valve assembly provided on the inlet and configured to operate the flow of the fluid introduced into the housing through the inlet to be allowed or blocked, and a gate member provided in the housing and configured to adjust an operation of the valve assembly.

公开(公告)号：US20230236157A1

公开(公告)日：2023-07-27

申请号：US18098932

申请日：2023-01-19

申请人： Alexander Bozic

发明人： Alexander Bozic

IPC分类号： G01N30/20 ,  G01N30/32 ,  G01N30/34 ,  B01F25/40 ,  B01D15/14

CPC分类号： G01N30/20 ,  G01N30/32 ,  G01N30/34 ,  B01F25/40 ,  B01D15/14 ,  G01N2030/385

摘要： A chromatography system comprising at least two pumps, a first pump which is connectable or connected with a liquid reservoir for a first fluid, and a second pump which is connectable or connected with a liquid reservoir for a second fluid, wherein the pump outlet lines from the first pump and the second pump are connected with a connection piece and, viewed in the direction of flow, a chromatography column is provided downstream of this connection piece, wherein, viewed in the direction of flow, an addition unit is provided upstream of the connection piece and a mixer switching valve and a mixer switchable by way of the mixer switching valve are provided between the connection piece and chromatography column, wherein the mixer switching valve has at least two switching positions, wherein the mixer is connectable in a first position and the mixer is bypassable in a second position.
A chromatography method in which the system is used and a conversion kit for converting a high-performance liquid chromatography system into a chromatography system for supercritical fluid chromatography are also disclosed.

公开(公告)号：US20230149831A1

公开(公告)日：2023-05-18

申请号：US18154703

申请日：2023-01-13

申请人： DIONEX SOFTRON GMBH

发明人： Daniel BUERGER ,  Michael SCHADL ,  Til RICHARDSEN

IPC分类号： B01D15/14 ,  G01N30/60

CPC分类号： B01D15/14 ,  G01N30/6026 ,  G01N30/6078 ,  G01N2030/027

摘要： A plug unit configured for use in high performance liquid chromatography is described. The plug unit comprises a capillary comprising a capillary distal face; a sealing element, wherein at least a portion of the sealing element is located distal from the capillary distal face; and a biasing element configured to bias the capillary towards the sealing element.

公开(公告)号：US20230136050A1

公开(公告)日：2023-05-04

申请号：US17971605

申请日：2022-10-23

申请人： SHIMADZU CORPORATION

发明人： Keisuke OGAWA ,  Andy SASAKI ,  Kerry HILL ,  Timothy LEE

IPC分类号： G01N30/46 ,  G01N30/32 ,  G01N30/20 ,  B01D15/18 ,  B01D15/16 ,  B01D15/14 ,  B01D15/42 ,  B08B9/032

摘要： A liquid chromatographic system includes a column, a needle, a valve, a pump, and an analysis flow path. The valve sets the analysis flow path by switching between a first flow path through which an eluent flows from the valve to the column via the needle and a second flow path through which the eluent flows from the valve to the column not via the needle. The first flow path can be cleaned by drive of a first cleaning pump while the first flow path is set, and the second flow path can be cleaned by drive of the first cleaning pump while the second flow path is set.

公开(公告)号：US11639514B2

公开(公告)日：2023-05-02

申请号：US16846025

申请日：2020-04-10

申请人： Leidos, Inc.

发明人： John Dresios ,  Richard Holmes Griffey ,  Challise J. Sullivan ,  Erik D. Pendleton ,  Henri M. Sasmor ,  William L. Hicks ,  Eric M. Amendt

IPC分类号： C12P21/00 ,  B01D15/34 ,  B01D15/36 ,  B01D15/38 ,  C12N9/12 ,  C07K14/505 ,  C07K14/535 ,  C12M1/40 ,  C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  B01D15/12 ,  B01D15/10 ,  B01D15/14 ,  B01D15/22 ,  C12P21/02 ,  C12N1/06 ,  C12P21/06

摘要： A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements. Protein synthesis and purification modules are integrated into self-contained disposable fluidic cartridge that eliminates cross-contamination between runs. The platform allows for flexible production of protein biologics within 24 hours (from DNA to purified product).

公开(公告)号：US20220411286A1

公开(公告)日：2022-12-29

申请号：US17851176

申请日：2022-06-28

申请人： TONGJI UNIVERSITY

发明人： Yalei Zhang ,  Xuefei Zhou ,  Yinchuan Yang ,  Jiabin Chen ,  Lei Wang ,  Xinmiao Zhang ,  Wenbiao Wang ,  Yegang Chen

IPC分类号： C02F1/00 ,  C02F1/28 ,  B01J20/28 ,  B01D15/14 ,  B01D15/18

摘要： A high salinity wastewater treatment system is provided according to the present application, which includes a hydrogel loading system and a flow-storage different-oriented-inlet-and-outlet system. The hydrogel loading system includes six separation plates, a wastewater treatment area, a water distribution bin, a rotating shaft, a driving motor and a fixed bracket. The six separation plates evenly separate the wastewater treatment area into six separate treatment sectors in an axial direction. The six separate treatment sectors are filled with hydrogel materials with water purification effect. The high salinity wastewater infiltrates into each separate treatment sector one by one through high salinity wastewater inlet meshes on a surface of the wastewater treatment area, and the purified high salinity wastewater is discharged through a wastewater cleaning outlet pipe with a same water inlet direction as a cleaning filler distribution pipe.

公开(公告)号：USRE49221E1

公开(公告)日：2022-09-27

申请号：US16456170

申请日：2019-06-28

申请人： Parker Intangibles, LLC

发明人： Karl G. Schick ,  David A. Uhen

IPC分类号： B01D61/20 ,  B01D15/10 ,  B01D61/18 ,  B01D61/22 ,  B01D15/14 ,  B01D15/24 ,  G01N27/10 ,  G01N30/88

摘要： Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds are adapted to interact with other equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also can be used in conjunction with one or more sensors such as pressure and conductivity sensors that interact with the controller or are connected to a separate user interface. An aseptic environment obtains avoiding or reducing cleaning and quality assurance procedures.