公开(公告)号：US20240301794A1

公开(公告)日：2024-09-12

申请号：US18668351

申请日：2024-05-20

申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

发明人： PHILIP METZGER

IPC分类号： E21C51/00 ,  B03C1/30 ,  B03C7/02 ,  B04C9/00 ,  B64G4/00 ,  B64G5/00

CPC分类号： E21C51/00 ,  B03C1/30 ,  B03C7/02 ,  B04C9/00 ,  B64G4/00 ,  B64G5/00 ,  B03C2201/20 ,  B04C2009/001

摘要： The system extracts water from lunar regolith and includes a regolith intake having a digging bucket that collects lunar regolith soil and a gravel separator that separates and discharges gravel and passes a mixture of ice-regolith powder having ice grains that are about 10-100 microns along the conveyor. A pneumatic separator receives the ice-regolith powder and pneumatically splits the ice-regolith powder into streams of different sized lithic fragments and ice particles per the ratio of inertial force and aerodynamic drag force of the lithic fragments and ice particles. Each split stream may include a magnetic separator that separates further the magnetic and paramagnetic lithic fragments from ice particles to discharge up to 80 percent of lithic fragments to slag.

公开(公告)号：US11891896B2

公开(公告)日：2024-02-06

申请号：US18307044

申请日：2023-04-26

申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

发明人： Philip Metzger

IPC分类号： E21C51/00 ,  B03C1/30 ,  B03C7/02 ,  B04C9/00 ,  B64G4/00 ,  B64G5/00

CPC分类号： E21C51/00 ,  B03C1/30 ,  B03C7/02 ,  B04C9/00 ,  B64G4/00 ,  B64G5/00 ,  B03C2201/20 ,  B04C2009/001

摘要： The system extracts water from lunar regolith and includes a regolith intake having a digging bucket that collects lunar regolith soil and a gravel separator that separates and discharges gravel and passes a mixture of ice-regolith powder having ice grains that are about 10-100 microns along the conveyor. A pneumatic separator receives the ice-regolith powder and pneumatically splits the ice-regolith powder into streams of different sized lithic fragments and ice particles per the ratio of inertial force and aerodynamic drag force of the lithic fragments and ice particles. Each split stream may include a magnetic separator that separates further the magnetic and paramagnetic lithic fragments from ice particles to discharge up to 80 percent of lithic fragments to slag.

公开(公告)号：US10800652B2

公开(公告)日：2020-10-13

申请号：US16123882

申请日：2018-09-06

申请人： Berkeley Lights, Inc.

发明人： Keith J. Breinlinger ,  Daniele Malleo ,  Gaetan L. Mathieu ,  J. Tanner Nevill ,  Alexander H. Slocum ,  Mark P. White

IPC分类号： B81B7/02 ,  B03C5/00 ,  B03C5/02 ,  G01N27/447 ,  B03C7/02 ,  G01N33/543 ,  B01L3/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/34 ,  G01N33/50

摘要： A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.

公开(公告)号：US10525410B2

公开(公告)日：2020-01-07

申请号：US14160138

申请日：2014-01-21

申请人： Stephen R. Temple ,  Howard Everett Whitney ,  Bjorn Temple

发明人： Stephen R. Temple ,  Howard Everett Whitney ,  Bjorn Temple

IPC分类号： F25J3/06 ,  B01D53/78 ,  B01D53/00 ,  B01D53/75 ,  B03C3/017 ,  B03C3/04 ,  B03C3/16 ,  B03C5/02 ,  B03C7/02 ,  B03C11/00 ,  B01D47/10

摘要： A method for removing noxious, hazardous, toxic, mutagenic, and/or carcinogenic compounds and/or precursor compounds from a comingled gas, liquid and/or solid stream is described. In one embodiment, the method includes optionally passing the stream through an ambient temperature condenser followed by passing the stream through a spray venturi scrubber, a chilled condenser, a gas/solid separator, and a series of wet scrubbers to remove at least a portion of the compounds.

公开(公告)号：US20190321781A1

公开(公告)日：2019-10-24

申请号：US16504136

申请日：2019-07-05

申请人： Stephen R. Temple ,  Howard Everett Whitney ,  Bjorn Temple

发明人： Stephen R. Temple ,  Howard Everett Whitney ,  Bjorn Temple

IPC分类号： B01D53/78 ,  B03C11/00 ,  F23G7/06 ,  B01D53/00 ,  B01D53/75 ,  F23J15/00 ,  B03C7/02 ,  B03C3/017 ,  B03C3/04 ,  B03C3/16 ,  B03C5/02 ,  F23J15/02

摘要： A method for removing noxious, hazardous, toxic, mutagenic, and/or carcinogenic compounds and/or precursor compounds from a comingled gas, liquid, and/or solid stream is described. In one embodiment, the method is used to prepare the stream for feeding to an oxidizer, such as a thermal oxidizer, to reduce the amount of particulate matter discharged by the oxidizer and includes passing the stream through an ambient or chilled temperature condenser followed by an optional gas/solid separator, and one or more gas scrubbers prior to feeding to the oxidizer.

公开(公告)号：US20190152771A1

公开(公告)日：2019-05-23

申请号：US16123882

申请日：2018-09-06

申请人： Berkeley Lights, Inc.

发明人： Keith J. Breinlinger ,  Daniele Malleo ,  Gaetan L. Mathieu ,  J. Tanner Nevill ,  Alexander H. Slocum ,  Mark P. White

IPC分类号： B81B7/02 ,  B03C5/02 ,  B01L3/00 ,  G01N33/543 ,  C12M3/06 ,  C12M1/00 ,  B03C5/00 ,  B03C7/02

摘要： A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.

公开(公告)号：US09981273B2

公开(公告)日：2018-05-29

申请号：US14042585

申请日：2013-09-30

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Mehdi Javanmard ,  Sam Emaminejad ,  Janine Mok ,  Michael N. Mindrinos

IPC分类号： B03C7/02 ,  B81B1/00 ,  B03C5/00 ,  B03C5/02

CPC分类号： B03C7/023 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  B81B1/006

摘要： The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.

公开(公告)号：US20170138831A1

公开(公告)日：2017-05-18

申请号：US15323579

申请日：2015-06-26

申请人： SHIMADZU CORPORATION ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Hiroshi OKUDA ,  Yoshihiro UENO ,  Hiroshi SEKI ,  Hiromu SAKURAI

IPC分类号： G01N15/02 ,  B03C3/38 ,  B03C3/68 ,  B03C7/02

CPC分类号： G01N15/0266 ,  B03C3/017 ,  B03C3/361 ,  B03C3/38 ,  B03C3/41 ,  B03C3/47 ,  B03C3/68 ,  B03C7/02 ,  B03C2201/06 ,  G01N2015/0038 ,  G01N2015/0288 ,  H01T19/04 ,  H01T23/00

摘要： In unipolar charging, a discharge current value at which charging efficiency is best and a discharge current dependency of multivalent charging differ depending on the particle size of the particles that are the object of charging. Therefore, for each particle size, a discharge voltage at which univalent charging efficiency is best and a discharge voltage at which the signal-to-noise ratio of a signal when particles of a different size are regarded as noise is best are obtained through experiment and stored in a storage unit (21). When scanning a classification voltage that is applied to a classification unit (32) of a DMA (3) to measure particle size distribution, a system controlling unit (2) acquires an optimal voltage corresponding to a particle size from the storage unit (21), and in conjunction with scanning of the classification voltage, controls a discharge power source (11) via a discharge voltage controlling unit (10) so that the discharge voltage is scanned in accordance with changes in particle size. It is thereby possible, for example, to reduce the amount of multivalent charged particles of different particle sizes that are mixed in with particles with a predetermined particle size that are extracted by classification, and to accurately determine the particle size distribution.

公开(公告)号：US09617145B2

公开(公告)日：2017-04-11

申请号：US14520510

申请日：2014-10-22

申请人： Berkeley Lights, Inc.

发明人： Keith J. Breinlinger ,  Daniele Malleo ,  Gaetan L. Mathieu ,  J. Tanner Nevill ,  Alexander H. Slocum ,  Mark P. White

IPC分类号： B03C7/02 ,  B81B7/02 ,  B03C5/00 ,  B03C5/02 ,  G01N33/00 ,  G01N27/447 ,  B01L3/00 ,  G01N33/50

CPC分类号： B81B7/02 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2400/0424 ,  B01L2400/0433 ,  B01L2400/0454 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  B03C7/023 ,  B03C2201/26 ,  C12M23/16 ,  C12M41/46 ,  C12M47/02 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/44791 ,  G01N33/5023 ,  G01N33/543 ,  G01N33/54326 ,  G01N35/10

摘要： A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.

公开(公告)号：US20170072395A1

公开(公告)日：2017-03-16

申请号：US15293062

申请日：2016-10-13

申请人： Biological Dynamics, Inc.

发明人： Rajaram KRISHNAN ,  David CHARLOT ,  Eugene TU ,  James MCCANNA ,  Lucas KUMOSA ,  Paul SWANSON ,  Robert TURNER ,  Kai YANG ,  Irina DOBROVOLSKAYA ,  David LIU

IPC分类号： B01L3/00 ,  C12Q1/68 ,  B03C7/02 ,  B03C5/00 ,  B03C5/02 ,  C12N15/10 ,  B01L7/00

CPC分类号： B01L3/502715 ,  B01D57/02 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C7/023 ,  B03C2201/26 ,  C12N15/1003 ,  C12N15/101 ,  C12Q1/6806 ,  G01N27/447 ,  G01N27/44704 ,  G01S5/163 ,  G01S11/12 ,  G06F3/0346

摘要： The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

摘要翻译： 本发明包括用于从包含细胞的流体分离核酸的方法，装置和系统。 在各个方面，方法，装置和系统可以允许需要最少量的材料和/或产生从诸如血液或环境样品的复杂流体分离的高纯度核酸的快速程序。