公开(公告)号：US11534114B2

公开(公告)日：2022-12-27

申请号：US16327638

申请日：2017-08-23

申请人： SIMON FRASER UNIVERSITY

发明人： Paul Schaffer ,  Hua Yang ,  Robert Britton ,  Matthew Nodwell ,  Zheliang Yuan

IPC分类号： A61B6/03 ,  C07K5/10 ,  A61K51/08 ,  C07K7/06 ,  C07K5/06 ,  C07K1/13 ,  C07K5/08 ,  C07K5/02 ,  C07B59/00 ,  A61K51/04 ,  C07C275/16 ,  C07C237/12 ,  C07C229/20 ,  C07C229/08 ,  C07C229/26 ,  C07C229/36

摘要： The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:

公开(公告)号：US11230522B2

公开(公告)日：2022-01-25

申请号：US16648344

申请日：2018-09-14

申请人： Covestro Deutschland AG

发明人： Dorota Greszta-Franz ,  Jan Weikard ,  Matthias Wintermantel ,  Robert Maleika ,  Thomas Klimmasch ,  Thomas Schuettler

IPC分类号： C07C227/40 ,  C07C229/24 ,  C07C227/06 ,  C07C229/26 ,  C08G18/38 ,  C08G18/79

摘要： The present invention relates to polyaspartic acid ester compositions which contain polyaspartic acid esters with primary amino groups and small amounts of fumaric acid dialkyl esters, to a method for preparing same and the use thereof as a reactive component for polyisocyanates in two-component polyurethane systems.

公开(公告)号：US11155524B2

公开(公告)日：2021-10-26

申请号：US16893319

申请日：2020-06-04

申请人： ThermoLife International, LLC

发明人： Ronald Kramer ,  Alexandros Nikolaidis

IPC分类号： C07D233/64 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26 ,  C07C237/06 ,  C07C275/16 ,  C07C323/58 ,  C07D207/16 ,  A61K31/198 ,  A61K31/401 ,  A61K31/4172 ,  A61K33/00 ,  A61K31/197 ,  C07C279/02

摘要： Methods of producing an amino acid nitrate supplement drink suitable for human consumption are provided. The methods comprise providing a solid nitrate salt of an amino acid and adding an amount of water to the solid nitrate salt of the amino acid to produce the amino acid and nitrate drink, wherein the amount of water is sufficient to dissolve the solid nitrate salt of the amino acid. In particular implementations, the solid nitrate salt of an amino acid is selected from the group consisting of: creatine nitrate, arginine nitrate, leucine nitrate, isoleucine nitrate, valine nitrate, cysteine nitrate, glycine nitrate, agmatine nitrate, beta-alanine nitrate, N-acetyl cysteine nitrate, aspartic acid nitrate, lysine nitrate, histidine nitrate, norvaline nitrate, ornithine nitrate, glutamine nitrate, citrulline nitrate, and betaine nitrate.

公开(公告)号：US20210261493A1

公开(公告)日：2021-08-26

申请号：US17190981

申请日：2021-03-03

申请人： KYOWA HAKKO BIO CO., LTD. ,  OTSUKA PHARMACEUTICAL FACTORY, INC.

发明人： Tomoya YOKOI ,  Hiroshi NAGANO ,  Takayuki SHIMIZU

IPC分类号： C07C227/42 ,  C07C229/26 ,  C07C51/41 ,  C07C59/01 ,  C07C51/43 ,  C07C277/06 ,  C07C279/14

摘要： An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.

公开(公告)号：US11066352B2

公开(公告)日：2021-07-20

申请号：US16611193

申请日：2018-05-07

申请人： OCERA THERAPEUTICS, INC.

发明人： Ludwig Pilsl ,  Georg Winkler ,  Frank Demartin ,  Vassil Elitzin

IPC分类号： C07C51/43 ,  C07C229/26 ,  C07C57/32

摘要： Embodiments of the present disclosure are related to improved processes for making L-ornithine phenylacetate without using any silver salts or forming any L-ornithine intermediate salts, such as a benzoate salt. The present processes may be used in the commercial scale manufacturing of L-ornithine phenylacetate with high yields and low impurities.

公开(公告)号：US20200330501A1

公开(公告)日：2020-10-22

申请号：US16867291

申请日：2020-05-05

申请人： Massachusetts Institute of Technology

发明人： Yizhou Dong ,  Kevin Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC分类号： A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US10682374B2

公开(公告)日：2020-06-16

申请号：US16126897

申请日：2018-09-10

申请人： Massachusetts Institute of Technology

发明人： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC分类号： A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US10435356B1

公开(公告)日：2019-10-08

申请号：US14065371

申请日：2013-10-28

申请人： ThermoLife International, LLC

发明人： Ronald Kramer ,  Alexander Nikolaidis

IPC分类号： A61K31/198 ,  C07C279/14 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26 ,  C07C279/16 ,  C07C237/06 ,  C07C279/12 ,  C07C323/58 ,  C07D207/16 ,  C07D233/64

摘要： A composition is disclosed that includes a Nitrate or a Nitrite of an Amino Acid Compound selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine, wherein the composition is formulated to deliver an effective amount of the Nitrate or Nitrite of the Amino Acid Compound to prevent the development of nitrate tolerances, to increase bioabsorption of amino acids, to increase the vasodilative characteristics of amino acids, or to increase athletic performance in a human or animal. The composition may be in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a powder, a granule, a pellet, a bead, a particle, a troche, a lozenge, a gel, a liquid, a suspension, a solution, an elixir, and a syrup.

公开(公告)号：US10434180B2

公开(公告)日：2019-10-08

申请号：US15214331

申请日：2016-07-19

申请人： Innate Pharma ,  Paul Scherrer Institut

发明人： Delphine Bregeon ,  Patrick Dennler ,  Christian Belmant ,  Laurent Gauthier ,  François Romagne ,  Eliane Fischer ,  Roger Schibli

IPC分类号： A61K31/5517 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C07C217/08 ,  C07C223/02 ,  C07C229/26 ,  C07C233/62 ,  C07C247/04 ,  C07D225/08 ,  C07D257/08 ,  C07D277/06 ,  C07F9/50 ,  C12N9/10 ,  C12P21/00 ,  G01N33/68 ,  A61K47/48 ,  A61K47/68

摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

公开(公告)号：US10420843B2

公开(公告)日：2019-09-24

申请号：US15824606

申请日：2017-11-28

申请人： Thetis Pharmaceuticals LLC

发明人： Frank C. Sciavolino ,  Gary Mathias ,  Michael C. Van Zandt ,  Gunnar Erik Jagdmann, Jr. ,  Jessica J. Dworak

IPC分类号： A61K31/202 ,  A61K31/232 ,  A61K38/03 ,  A61K45/06 ,  A61K47/62 ,  A61K47/54 ,  A61P1/04 ,  A61P1/06 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  C07C229/26 ,  C07C237/12 ,  C07C237/22 ,  C07C59/42

摘要： The present invention relates to compounds of Formula IV, compositions comprising same, and their use in therapy wherein A and B are each independently a specialized pro-resolving mediator (“SPM”) molecule selected from an E series resolvin, a D series resolvin, and their aspirin-triggered counterparts, and M, R1, R2, X1and X2 are as defined herein.