公开(公告)号：US20240055022A1

公开(公告)日：2024-02-15

申请号：US18489053

申请日：2023-10-18

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： MASAKO YOKOYAMA ,  TERUHIKO SAITO ,  KOTA ANDO ,  HIDEKAZU ARASE

IPC分类号： G11B7/244 ,  C07C15/50 ,  C07C25/24 ,  C07C22/08 ,  C07C39/21 ,  C07C63/66 ,  C07C69/76 ,  C07C49/796 ,  C07C233/65 ,  C07C255/50 ,  C07C47/548 ,  C07C321/26 ,  C07C309/32 ,  C07C327/26 ,  C07C317/14 ,  C07C311/16 ,  C07C211/45 ,  C07C205/06

CPC分类号： G11B7/244 ,  C07C15/50 ,  C07C25/24 ,  C07C22/08 ,  C07C39/21 ,  C07C63/66 ,  C07C69/76 ,  C07C49/796 ,  C07C233/65 ,  C07C255/50 ,  C07C47/548 ,  C07C321/26 ,  C07C309/32 ,  C07C327/26 ,  C07C317/14 ,  C07C311/16 ,  C07C211/45 ,  C07C205/06

摘要： A nonlinear light absorption material includes a compound represented by the following formula (1) as a main component:




in the formula (1), R1 to R10 are each independently a hydrogen atom, a halogen atom, a saturated hydrocarbon group, a halogenated alkyl group, an unsaturated hydrocarbon group, a hydroxyl group, a carboxyl group, an alkoxycarbonyl group, an aldehyde group, an acyl group, an amide group, a nitrile group, an alkoxy group, an acyloxy group, a thiol group, an alkylthio group, a sulfonate group, an acylthio group, an alkylsulfonyl group, a sulfonamide group, a primary amino group, a secondary amino group, a tertiary amino group, or a nitro group.

公开(公告)号：US20240051975A1

公开(公告)日：2024-02-15

申请号：US18258346

申请日：2022-02-14

申请人： TSINGHUA UNIVERSITY

发明人： Gelin WANG ,  Yefeng TANG ,  Hong YAO ,  Minghui LIU ,  Leibo WANG ,  Chenyu LI ,  Ruoxi ZHANG ,  Yumeng ZU ,  Chuo WU ,  Feifei LI ,  Shuangquan CHEN

IPC分类号： C07F5/02 ,  C07C235/24 ,  C07D213/65 ,  C07C255/50 ,  C07C311/16 ,  C07C279/04 ,  A61P25/28

CPC分类号： C07F5/025 ,  C07C235/24 ,  C07D213/65 ,  C07C255/50 ,  C07C311/16 ,  C07C279/04 ,  A61P25/28 ,  C07C2601/16

摘要： The present invention provides a class of novel NAMPT enzyme agonist and preparation and use thereof, which has a structural formula as shown in formula I or formula II. The present invention screens the NAMPT agonist NAT from the chemical small molecule library, and the NAT exhibits a good cytoprotective effect and a good anti-neurodegeneration effect in animal models of neurodegeneration. We studied the binding of NAT to enzymes, and then carried out multiple rounds of structure optimization based on the chemical structure characteristics of NAT and its enzyme activity properties, and obtained a relatively defined structure-activity relationship. The present patent not only lays the foundation for developing innovative drugs for anti-aging and neurodegenerative diseases, but also theoretically provides a proof-of-concept that enhancing NAMPT enzyme activity plays an important role in neuroprotection.

公开(公告)号：US20220378675A1

公开(公告)日：2022-12-01

申请号：US17829538

申请日：2022-06-01

申请人： CHEMCON S.A. ,  GIVAUDAN S.A.

发明人： Pierre Chatelain ,  Markus Gautschi ,  Thierry Granier ,  Yannick Quesnel ,  Charles Stanley Sell ,  Alex Veithen

IPC分类号： A61K8/36 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61Q15/00 ,  C07C33/20 ,  C07C49/217 ,  C07C57/03 ,  C07C69/003 ,  C07C233/09 ,  C07C255/50 ,  C11B9/00

摘要： The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

公开(公告)号：US20220289704A1

公开(公告)日：2022-09-15

申请号：US17632913

申请日：2020-08-07

申请人： IDEMITSU KOSAN CO.,LTD.

发明人： Hiroaki ITOI ,  Yuki NAKANO ,  Satomi TASAKI ,  Taro YAMAKI

IPC分类号： C07D311/82 ,  C07D407/10 ,  C07D405/10 ,  C07F7/08 ,  C07D335/12 ,  C07D409/10 ,  C09K11/06 ,  C07C15/62 ,  C07D209/86 ,  C07D213/16 ,  C07F9/28 ,  C07D235/08 ,  C07D277/66 ,  C07D279/22 ,  C07D223/24 ,  C07C49/76 ,  C07C211/54 ,  C07D333/54 ,  C07D215/06 ,  C07C321/26 ,  C07D487/22 ,  C07F5/02 ,  C07D405/14 ,  C07C13/62 ,  C07D409/04 ,  C07C255/50 ,  C07D493/04 ,  H01L51/00

摘要： An organic electroluminescence device comprising: a cathode, an anode, and an organic layer disposed between the cathode and the anode, wherein the organic layer comprises a compound represented by the following formula (1), and a compound A having a Stokes shift of 20 nm or smaller and an emission peak wavelength of 440 nm to 465 nm (at least one of Ar1 and Ar2 is a monovalent group having a structure represented by the following formula (2)).

公开(公告)号：US20220259222A1

公开(公告)日：2022-08-18

申请号：US17587555

申请日：2022-01-28

申请人： Celgene Corporation

发明人： Alexander L. Ruchelman ,  John R. Coombs ,  Keming Zhu ,  Daniel Lim ,  Candice Lee Joe ,  David T. George ,  Bin Zheng ,  Dong Lin

IPC分类号： C07D495/14 ,  C07C255/50 ,  C07D215/58 ,  C07D495/04

摘要： The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

公开(公告)号：US11382848B2

公开(公告)日：2022-07-12

申请号：US16480331

申请日：2018-01-30

申请人： CHEMCOM S.A. ,  GIVAUDAN S.A.

发明人： Pierre Chatelain ,  Markus Gautschi ,  Thierry Granier ,  Yannick Quesnel ,  Charles Stanley Sell ,  Alex Veithen

IPC分类号： A61K8/34 ,  A61K8/36 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61Q15/00 ,  C07C33/20 ,  C07C49/217 ,  C07C57/03 ,  C07C69/003 ,  C07C233/09 ,  C07C255/50 ,  C11B9/00

摘要： The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

公开(公告)号：US11302870B2

公开(公告)日：2022-04-12

申请号：US16346598

申请日：2017-10-30

申请人： Merck Patent GmbH

发明人： Amir Parham ,  Dominik Joosten ,  Aurélie Ludemann ,  Tobias Grossmann ,  Jonas Kroeber

IPC分类号： H01L51/00 ,  C07C211/61 ,  C07C209/74 ,  C09K11/06 ,  C07C211/57 ,  C07D307/91 ,  C07D333/76 ,  C07D241/38 ,  C07D405/12 ,  C07D209/86 ,  C07D471/06 ,  C07C255/50 ,  C07D239/70 ,  C07D221/18 ,  C07C255/51 ,  C07D471/04 ,  C07D495/04 ,  C07D239/74 ,  C07D491/048 ,  C07D213/38 ,  H01L51/50

摘要： The present application relates to fluoranthenylamine compounds of a formula (I). These compounds are suitable for use in electronic devices, The present application further relates to processes for preparing the compounds mentioned, and to electronic devices comprising the compounds mentioned.

公开(公告)号：US11084784B2

公开(公告)日：2021-08-10

申请号：US15128932

申请日：2015-03-25

申请人： PIRAMAL ENTERPRISES LIMITED

发明人： Rajiv Sharma ,  Bichismita Sahu ,  Sunil Vasantrao Mali ,  Deepak Singh ,  Pramod Bhaskar Kumar ,  Mahesh Dawange ,  Hitesh Mistry

IPC分类号： C07C317/32 ,  C07D311/22 ,  C07D335/06 ,  C07D265/36 ,  C07D207/27 ,  C07D295/26 ,  C07C233/29 ,  C07C237/22 ,  A61K31/18 ,  A61K31/351 ,  C07C217/88 ,  C07C317/24 ,  C07C311/08 ,  C07C255/46 ,  C07C233/54 ,  C07C217/48 ,  C07C211/45 ,  C07C215/70 ,  C07C255/50 ,  A61K31/277 ,  C07C309/89 ,  C07C225/22 ,  C07C229/42 ,  C07C317/44 ,  A61K31/165 ,  C07C323/09 ,  A61K31/5375 ,  C07C311/37 ,  C07F5/02 ,  A61K31/402 ,  C07D317/72 ,  C07C217/76 ,  C07C205/36 ,  A61K31/382 ,  C07F7/18 ,  C07C237/52 ,  C07C311/21 ,  C07C381/10 ,  C07D211/14 ,  C07D213/30 ,  C07D231/12 ,  C07D233/58 ,  C07D257/04 ,  C07D295/088 ,  C07D295/135 ,  C07D295/192 ,  C07D305/08

摘要： The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparation. The invention further relates to pharmaceutical compositions containing the compounds and their use in the treatment of diseases or disorders mediated by RORγ.

公开(公告)号：US10899687B2

公开(公告)日：2021-01-26

申请号：US15763848

申请日：2016-10-06

申请人： Technion Research & Development Foundation Limited

发明人： Mark Gandelman ,  Gennady Nisnevich ,  Kseniya Kulbitski ,  Alexander Artaryan

IPC分类号： C07C17/363 ,  C07C25/06 ,  C07C25/08 ,  C07C25/10 ,  C07C25/13 ,  C07C201/12 ,  C07C253/30 ,  C07B39/00 ,  C07C19/01 ,  C07C25/02 ,  C07C205/08 ,  C07C205/12 ,  C07C205/37 ,  C07C255/50 ,  C07D307/89

摘要： The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

公开(公告)号：US10693075B2

公开(公告)日：2020-06-23

申请号：US15670174

申请日：2017-08-07

申请人： NICHEM FINE TECHNOLOGY CO., LTD.

发明人： Tai-Ni Lu ,  Liang-Di Liao ,  Shwu-Ju Shieh ,  Chi-Chung Chen

IPC分类号： H01L51/00 ,  C07C255/50 ,  C07C255/51 ,  C07D213/57 ,  C07D233/58 ,  C07D239/74 ,  C07D251/24 ,  C07B59/00 ,  C07D307/94 ,  C07D333/80 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  H01L51/50 ,  H01L51/52

摘要： Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): wherein X1 and X2 are each independently C(Ra), multiple (Ra)s are the same or different, and the two (Ra)s are joined together to form an aryl ring; wherein X3 and X4 are each independently C(Rb), multiple (Rb)s are the same or different, and the two (Rb)s are joined together to form a polycyclic aromatic ring.