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公开(公告)号:US11572337B2
公开(公告)日:2023-02-07
申请号:US16978135
申请日:2019-03-06
发明人: Richard H. Ebright , Yon W. Ebright , Joel S. Freundlich , Ricardo Gallardo-Macias , Shao-Gang Li
IPC分类号: C07C235/60 , C07D239/34 , C07D213/65 , C07D213/56 , A61P31/04 , A01N43/54 , A01N43/40 , A01N37/44 , C07D213/30 , C07D213/68 , C07D295/096
摘要: The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.
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公开(公告)号:US20220396581A1
公开(公告)日:2022-12-15
申请号:US17228573
申请日:2021-04-12
发明人: Guangyi WANG , Leonid BEIGELMAN , Anh TRUONG , Carmela NAPOLITANO , Daniele ANDREOTTI , Haiying HE
IPC分类号: C07D495/04 , A61K31/352 , A61K31/4196 , A61K31/4365 , C07C255/66 , C07D233/88 , C07D261/20 , C07D307/40 , C07D307/52 , C07D333/20 , C07D333/58 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/4375 , A61K31/4725 , C07D213/50 , C07D233/64 , C07D333/68 , C07D401/12 , C07D409/06 , A61K31/343 , A61K31/382 , A61K31/426 , A61K31/4418 , A61K31/4545 , C07C251/84 , C07D207/335 , C07D215/12 , C07D215/42 , C07D233/61 , C07D401/04 , C07D409/14 , A61K31/277 , A61K31/407 , A61K31/423 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , C07C243/34 , C07D209/20 , C07D209/86 , C07D233/38 , C07D233/60 , C07D277/64 , C07D307/81 , C07D405/10 , C07D417/04 , C07D417/12 , A61K31/165 , A61K31/40 , A61K31/4709 , C07C243/18 , C07D277/56 , C07D333/66 , C07D413/04 , C07D471/04 , C07D495/14 , A61K31/4427 , A61K31/5377 , C07D213/42 , C07D213/68 , C07D215/38 , C07D217/24 , C07D307/91 , C07D311/68 , C07D333/16 , C07D333/62 , C07D401/10 , C07D409/12 , A61K31/341 , A61K31/4164 , A61K31/428 , A61K31/444 , A61K31/4704 , A61K31/501 , A61K45/06 , C07C255/34 , C07D209/08 , C07D215/14 , C07D333/54 , C07D335/06 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/12 , C07D413/14 , A61K31/381 , A61K31/4155 , A61K31/47 , A61K31/538 , C07C251/80 , C07D209/14 , C07D213/65 , C07D333/50 , C07D333/76
摘要: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号:US20220299521A1
公开(公告)日:2022-09-22
申请号:US17596208
申请日:2020-06-04
IPC分类号: G01N33/68 , A61K47/68 , C07D213/53 , C07D213/68 , C07D213/74 , C07D213/81 , C07D401/04 , C07D401/14 , C07D235/14
摘要: The invention pertains to chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule for analysis of a peptide, protein, antibody, protein bioconjugate, antibody bioconjugate, and similar analytes. The sensitivity booster comprises of sp2 or sp3 nitrogen centers in combination with hydrophobic carbon chains linked with an electrophile or nucleophile for attachment with a peptide, peptide conjugate, or molecules with similar reactivity.
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公开(公告)号:US20220204457A1
公开(公告)日:2022-06-30
申请号:US17441572
申请日:2020-03-20
申请人: Cortexyme, Inc.
IPC分类号: C07D239/34 , C07C279/28 , C07C279/24 , C07C279/12 , C07D213/68 , C07D213/82 , C07D261/12
摘要: Therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A and arginine gingipain B, are disclosed, as well as the use thereof for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, Formula Ia, and Formula Ib, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号:US11312676B2
公开(公告)日:2022-04-26
申请号:US15540386
申请日:2015-12-29
发明人: David Michael Lonard , Lei Wang , Bert W. O'Malley , Jianming Xu , Yongcheng Song , Xiaonan Li , Timothy Gerald Palzkill
IPC分类号: C07C49/753 , A61K31/444 , A61K31/45 , A61K31/4402 , A61K31/351 , A61K31/4433 , A61K31/122 , A61K31/4545 , C07D401/06 , C07D309/38 , C07D405/06 , C07D213/68 , C07D405/12 , A61P35/00 , C07C49/697 , C07D211/86 , C07D213/50 , C07D309/32 , C07D401/14 , C07D405/14
摘要: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.
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公开(公告)号:US11246949B2
公开(公告)日:2022-02-15
申请号:US14116270
申请日:2012-05-11
IPC分类号: A61B5/055 , A61K49/10 , C07D213/74 , C07D213/58 , C07D213/59 , G01N33/52 , C07D213/53 , C07D213/68 , C07D471/04
摘要: Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents.
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公开(公告)号:US11000038B2
公开(公告)日:2021-05-11
申请号:US16500480
申请日:2018-04-10
发明人: Hideki Umetani , Kazuki Kitajima , Takeshi Fukumoto , Masanori Yanagi , Akihiro Nishida , Ryohei Naito , Koya Saito , Tomomi Shirakawa , Hikaru Koishihara , Akane Sakurada , Satoshi Yutani , Toshiaki Ohara
IPC分类号: A01N43/40 , C07D213/68 , C07D413/04 , C07D401/04
摘要: A pyridone compound represented by Formula (1): wherein R1, R2, X, Y and Z are defined. The pyridone compound can control plant diseases.
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公开(公告)号:US20200333351A1
公开(公告)日:2020-10-22
申请号:US16838004
申请日:2020-04-01
发明人: Kyle Gee , Upinder Singh , Scott Grecian , Scott Clarke
IPC分类号: G01N33/58 , G01N33/533 , C07D213/74 , C07D213/79 , C07D213/81 , C07D215/12 , C07D401/04 , C07D235/14 , C07D213/53 , C07D213/68 , C07D213/78 , C09B23/06 , C09B23/08 , C09B11/24 , C07D401/14 , C07K14/575
摘要: Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.
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公开(公告)号:US20200216386A1
公开(公告)日:2020-07-09
申请号:US16714062
申请日:2019-12-13
申请人: City of Hope
发明人: Linda H. Malkas , David Horne , Robert J. Hickey , Long Gu
IPC分类号: C07C233/76 , C07C237/22 , C07D217/26 , C07D401/12 , A61K31/4418 , A61K31/4725 , A61K31/4409 , A61K31/167 , A61P35/00 , A61P35/02 , C07D213/68 , A61K33/24
摘要: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
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公开(公告)号:US10696651B2
公开(公告)日:2020-06-30
申请号:US16323863
申请日:2017-08-09
发明人: Jun Fujimoto , Xin Liu , Osamu Kurasawa , Terufumi Takagi , Douglas Robert Cary , Hiroshi Banno , Yasutomi Asano , Takuto Kojima
IPC分类号: C07D401/12 , C07D403/12 , C07D401/14 , C07D213/75 , C07D405/12 , C07D239/42 , C07D241/12 , C07D471/04 , C07D498/04 , C07D213/65 , A61P35/00 , C07D241/20 , C07D213/73 , A61K31/53 , A61K31/505 , A61K31/4406 , A61K31/444 , A61K31/4965 , C07D213/68 , C07D213/42 , A61K31/506 , A61K31/497 , A61K31/4375 , C07D239/20 , A61P43/00 , A61K31/5383 , A61K31/437 , A61K31/44 , C07D253/06 , C07D231/12 , C07D239/30 , C07D239/34 , C07D239/48 , C07D253/07 , C07D409/12 , C07D487/04
摘要: Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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