公开(公告)号：US12103916B2

公开(公告)日：2024-10-01

申请号：US15836675

申请日：2017-12-08

申请人： University of Kentucky Research Foundation

发明人： Sylvie Garneau-Tsodikova ,  Sanjib K Shrestha ,  Atefeh Garzan ,  Nishad Thamban Chandrika

IPC分类号： C07D249/08 ,  A01N33/08 ,  A01N43/60 ,  A01N43/653 ,  A01N43/84 ,  A01N47/12 ,  A61P31/10 ,  C07C217/08 ,  C07C271/16 ,  C07D295/03 ,  C07D403/06 ,  C07D405/06

CPC分类号： C07D249/08 ,  A01N33/08 ,  A01N43/60 ,  A01N43/653 ,  A01N43/84 ,  A01N47/12 ,  A61P31/10 ,  C07C217/08 ,  C07C271/16 ,  C07D295/03 ,  C07D403/06 ,  C07D405/06

摘要： Compounds and compositions having antifungal activity, and methods of using the antifungal compounds and compositions, are described for use in treating fungal infections.

公开(公告)号：US11517528B2

公开(公告)日：2022-12-06

申请号：US16622109

申请日：2018-06-15

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： Hideyoshi Harashima ,  Yusuke Sato

IPC分类号： A61K31/713 ,  C07D211/32 ,  A61K9/127 ,  C07D295/03

摘要： A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): (R1)(R2)C(OH)—(CH3)a—(O—CO)b—X  (I) [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R3 and R4 each independently represents a C1-4 alkyl group or a C2-4 alkenyl group, where, R3 and R4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C1-4 alkyl groups or C2-4 alkenyl groups may be substituted on the ring)].

公开(公告)号：US11434206B2

公开(公告)日：2022-09-06

申请号：US16984467

申请日：2020-08-04

申请人： HONOUR (R&D)

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subhash Chander Reddy ,  Kancharla Rajendar Reddy

IPC分类号： C07D241/20 ,  C07C211/06 ,  A61K31/495 ,  C07C211/05 ,  C07C211/07 ,  C07C211/08 ,  A61K31/4965 ,  C07D295/03

摘要： The present invention relates to a process for the preparation of amorphous Selexipag from Selexipag crystalline salts using a solvent.

公开(公告)号：US11299559B2

公开(公告)日：2022-04-12

申请号：US16754600

申请日：2018-11-30

申请人： LG Chem, Ltd.

发明人： Ho Young Lee ,  Jae Hoon Choe ,  Kyung Chang Seo ,  No Ma Kim

IPC分类号： C08C19/28 ,  C07C211/27 ,  C07D295/03 ,  C07D295/033 ,  C08F236/10 ,  C08K3/36 ,  B60C1/00

摘要： A modified conjugated diene-based polymer and a rubber composition including a modified conjugated diene-based polymer are disclosed herein. In some embodiments, a modified conjugated diene-based polymer includes a functional group derived from a modification initiator at one terminal and a functional group derived from a modifier represented by the Formula 2 or Formula 3 at the other terminal, wherein the modified conjugated diene-based polymer having a unimodal molecular weight distribution, and a polydispersity index of 1.0 to less than 1.7. The modified conjugated diene-based polymer prepared by continuous polymerization and having remarkable processability, narrow molecular weight distribution and excellent physical properties.

公开(公告)号：US11078171B2

公开(公告)日：2021-08-03

申请号：US16872114

申请日：2020-05-11

申请人： University of Maryland, Baltimore

发明人： Paul S. Shapiro ,  Alexander D. Mackerell, Jr. ,  Jeffrey D. Hasday ,  Steven Fletcher

IPC分类号： C07D295/03

摘要： Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

公开(公告)号：US10982337B2

公开(公告)日：2021-04-20

申请号：US15769460

申请日：2016-10-17

申请人： SCHLUMBERGER TECHNOLOGY CORPORATION

发明人： Lynne Patricia Crawford ,  Evgeny Borisovich Barmatov ,  Trevor Lloyd Hughes ,  Man Yi Ho

IPC分类号： C23F11/04 ,  C09K8/54 ,  C07D209/08 ,  C07D209/14 ,  C07D215/06 ,  C07D215/08 ,  C07D295/03

摘要： A corrosion inhibiting compound with a general structure A-B or A-X-B for inhibition of corrosion of steel in acidic solution. A comprises a heterocyclic ring system having a plurality of cyclic Carbon atoms and at least one cyclic Nitrogen atom, wherein the at least one cyclic Nitrogen atom is neutral under neutral conditions and protonatable under acidic conditions. B comprises at least two unsaturated Carbon atoms. B may comprise a ring system or a polymerisable group.

公开(公告)号：US10144700B2

公开(公告)日：2018-12-04

申请号：US15920654

申请日：2018-03-14

申请人： Purdue Research Foundation

发明人： Mingji Dai ,  Val J. Watts ,  Zhishi Ye

IPC分类号： C07C211/28 ,  C07D209/14 ,  C07C229/34 ,  C07C229/38 ,  C07C211/30 ,  C07C217/62 ,  C07C211/45 ,  C07D295/03 ,  C07C211/27 ,  C07C215/34 ,  C07D471/04 ,  C07C239/20 ,  C07C211/55 ,  C07C311/16 ,  C07D223/16 ,  C07C229/14 ,  C07C233/05

摘要： The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.

公开(公告)号：US20170226072A1

公开(公告)日：2017-08-10

申请号：US15494789

申请日：2017-04-24

申请人： University of Kentucky Research Foundation

发明人： Peter A. CROOKS ,  Linda P. DWOSKIN ,  John CULVER ,  Justin R. NICKELL ,  Guangrong ZHENG

IPC分类号： C07D295/096 ,  C07D295/073 ,  C07D211/22 ,  C07D211/18 ,  C07D211/14 ,  C07D295/03

CPC分类号： C07D295/096 ,  C07D211/08 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D295/02 ,  C07D295/03 ,  C07D295/073

摘要： The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.

公开(公告)号：US09624232B2

公开(公告)日：2017-04-18

申请号：US14827104

申请日：2015-08-14

申请人： Rhodes Technologies

发明人： Joshua Robert Giguere ,  Keith Edward McCarthy ,  Helge Alfred Reisch ,  Sergio Sandoval ,  Jake Larry Stymiest

IPC分类号： C07D471/00 ,  C07D489/08 ,  B01J31/24 ,  B01J31/18 ,  B01J31/22 ,  B01J31/20 ,  B01J23/42 ,  B01J23/44 ,  C07D295/03 ,  C07D295/205 ,  C07C209/00 ,  C07C269/04 ,  C07D265/30 ,  C07C209/44

CPC分类号： C07D489/08 ,  B01J23/42 ,  B01J23/44 ,  B01J31/1855 ,  B01J31/20 ,  B01J31/2295 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/64 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07C209/00 ,  C07C209/44 ,  C07C269/04 ,  C07D265/30 ,  C07D295/03 ,  C07D295/205 ,  Y02P20/55 ,  C07C211/21 ,  C07C271/12

摘要： The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

公开(公告)号：US09549983B2

公开(公告)日：2017-01-24

申请号：US14255637

申请日：2014-04-17

申请人： Dicerna Pharmaceuticals, Inc.

发明人： Bob Dale Brown ,  Sujit Kumar Basu ,  David A. Schwartz ,  Allister Fraser

IPC分类号： A61K47/18 ,  A61K31/713 ,  A61K47/22 ,  C12N15/113 ,  A61K9/127 ,  C12N15/11 ,  C12N15/88 ,  C07D233/61 ,  C07D233/64 ,  C07D239/42 ,  C07D241/04 ,  C07C237/06 ,  C07D295/03 ,  C07D211/36 ,  C07D295/13 ,  C07D295/15 ,  C07C211/21 ,  A61K38/00

CPC分类号： C07D403/06 ,  A61K9/107 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/145 ,  A61K9/146 ,  A61K31/713 ,  A61K38/00 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C237/06 ,  C07D211/36 ,  C07D233/61 ,  C07D233/64 ,  C07D239/42 ,  C07D241/04 ,  C07D243/08 ,  C07D295/03 ,  C07D295/13 ,  C07D295/15 ,  C07D401/04 ,  C07D403/04 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2320/32 ,  C12Y204/02008

摘要： The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

摘要翻译： 本发明涉及脂质化合物及其用途。 特别地，化合物包括具有胺部分的一类阳离子脂质，例如氨基胺或氨基 - 酰胺部分。 脂质化合物可用于体内或体外递送一种或多种试剂（例如聚阴离子载体或反义载体，例如RNAi试剂）。