公开(公告)号：US12114660B2

公开(公告)日：2024-10-15

申请号：US18359316

申请日：2023-07-26

申请人： CORTEVA AGRISCIENCE LLC

发明人： Karla Bravo-Altamirano ,  Yu Lu ,  Brian A. Loy ,  Zachary A. Buchan ,  David M. Jones ,  Jeremy Wilmot ,  Jared W. Rigoli ,  Kyle A. Dekorver ,  John F. Daeuble, Sr. ,  Jessica Herrick ,  Xuelin Wang ,  Chenglin Yao ,  Kevin G. Meyer

IPC分类号： A01N47/12 ,  A01N25/00 ,  A01N37/44 ,  A01N43/10 ,  A01N43/16 ,  A01N43/40 ,  A01P3/00 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C235/52 ,  C07C271/22 ,  C07D213/81 ,  C07D311/82 ,  C07D313/00 ,  C07D333/16 ,  C07D405/12 ,  C07D409/14

CPC分类号： A01N47/12 ,  A01N25/00 ,  A01N37/44 ,  A01N43/10 ,  A01N43/16 ,  A01N43/40 ,  A01P3/00 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C235/52 ,  C07C271/22 ,  C07D213/81 ,  C07D311/82 ,  C07D313/00 ,  C07D333/16 ,  C07D405/12 ,  C07D409/14

摘要： This disclosure relates to picolinamides of Formula I and their use as fungicides.

公开(公告)号：US20240208921A1

公开(公告)日：2024-06-27

申请号：US18540458

申请日：2023-12-14

申请人： University of Cincinnati

发明人： Harshita Kumari ,  Ajaz Ahmad Dar

IPC分类号： C07D333/16 ,  A01N59/16 ,  A61K47/54 ,  C09D4/00 ,  C09D5/16

CPC分类号： C07D333/16 ,  A01N59/16 ,  A61K47/545 ,  C09D4/00 ,  C09D5/1625

摘要： A novel composition is provided. The composition is a tetrameric reaction product of heterocyclic 3-thiophenecarboxaldehyde and an aromatic compound, the reaction product being a calix[4]arene. In one embodiment, the present invention is a thiophene functionalized calixarene selected from the group consisting of C-thiopheneresorcin[4]arene and C-thiophenepyrogallol[4]arene. In another embodiment, the thiophene functionalized calixarene further comprises silver nanoparticles.

公开(公告)号：US11926575B2

公开(公告)日：2024-03-12

申请号：US17628980

申请日：2020-06-22

申请人： Sumitomo Chemical Company, Limited

发明人： Keisuke Takahashi

IPC分类号： C07C245/08 ,  C07D277/30 ,  C07D277/66 ,  C07D333/16 ,  C07D333/60 ,  C07D513/04 ,  C08F220/34 ,  G02B5/30

CPC分类号： C07C245/08 ,  C07D277/30 ,  C07D277/66 ,  C07D333/16 ,  C07D333/60 ,  C07D513/04 ,  C08F220/346 ,  G02B5/30

摘要： Provided is a compound represented by formula (1). In formula (1), Ar1, Ar2, and Ar3 represent a 1,4-phenylene group or a divalent sulfur-containing aromatic heterocyclic group optionally having a substituent, and at least one of Ar1 and Ar2 has a fluorine atom as a substituent; n represents 1 or 2; R1 represents a single bond or a group selected from the group consisting of —OC(═O)—, —C(═O)O—, —C≡C—, —CH═CH—, —CH═N—, and —N═CH—; R2 represents an alkylamino group or an alkoxy group; R3 represents a group selected from the group consisting of an alkanediyl group, an alkanediyloxy group, an alkanediyloxycarbonyl group, and an alkanediylcarbonyloxy group; and R4 represents a polymerizable group or a hydrogen atom.

R4—R3—Ar1—(—R1—Ar2—)n-N═N-Ar3—R2  (1)

公开(公告)号：US20230371516A1

公开(公告)日：2023-11-23

申请号：US18359316

申请日：2023-07-26

申请人： CORTEVA AGRISCIENCE LLC

发明人： KARLA BRAVO-ALTAMIRANO ,  YU LU ,  BRIAN A. LOY ,  ZACHARY A. BUCHAN ,  DAVID M. JONES ,  JEREMY WILMOT ,  JARED W. RIGOLI ,  KYLE A. DEKORVER ,  JOHN F. DAEUBLE ,  JESSICA HERRICK ,  XUELIN WANG ,  CHENGLIN YAO ,  KEVIN G. MEYER

IPC分类号： A01N47/12 ,  A01N43/40 ,  A01N43/10 ,  A01P3/00 ,  A01N37/44 ,  A01N25/00 ,  C07D313/00 ,  A01N43/16 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C235/52 ,  C07C271/22 ,  C07D213/81 ,  C07D311/82 ,  C07D333/16 ,  C07D405/12 ,  C07D409/14

CPC分类号： A01N47/12 ,  A01N43/40 ,  A01N43/10 ,  A01P3/00 ,  A01N37/44 ,  A01N25/00 ,  C07D313/00 ,  A01N43/16 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C235/52 ,  C07C271/22 ,  C07D213/81 ,  C07D311/82 ,  C07D333/16 ,  C07D405/12 ,  C07D409/14

摘要： This disclosure relates to picolinamides of Formula I and their use as fungicides.

公开(公告)号：US11661408B2

公开(公告)日：2023-05-30

申请号：US17274702

申请日：2019-08-28

申请人： SHOWA DENKO K.K.

发明人： Daisuke Yagyu ,  Naoya Fukumoto ,  Tsuyoshi Kato ,  Katsumi Murofushi

IPC分类号： C07D333/16 ,  G11B5/725 ,  C10M107/38 ,  G11B5/72 ,  C10N40/18

CPC分类号： C07D333/16 ,  C10M107/38 ,  G11B5/7257 ,  G11B5/7266 ,  C10N2040/18

摘要： The fluorine-containing ether compound is represented by the following formula (1): R1—R2—CH2—R3—CH2—R4. In the formula (1), R1 is represented by the following formula (2), R2 is represented by the following formula (3), R3 is a perfluoropolyether chain, and R4 is an organic end group different from R1—R2— and contains two or three polar groups, wherein each polar group is bonded to a different carbon atom, and the carbon atoms to which the polar groups are bonded are bonded to one another via a linking group containing a carbon atom to which the polar group is not bonded. In the formula (2), r is 1 to 3. In the formula (3), w is 2 or 3.

公开(公告)号：US11465989B2

公开(公告)日：2022-10-11

申请号：US15304798

申请日：2015-04-17

申请人： IMMUNOMET THERAPEUTICS INC.

发明人： Sung Wuk Kim ,  Hong Woo Kim ,  Sang Hee Yoo ,  Ji Sun Lee ,  Hye Jin Heo ,  Hong Bum Lee ,  Ji Ae Kook ,  Young Woo Lee ,  Mi Jeong Kim ,  Woong Cho

IPC分类号： C07D295/13 ,  C07D213/38 ,  C07D213/40 ,  C07D333/20 ,  C07D333/16 ,  C07D249/14 ,  C07D251/18 ,  C07D251/48 ,  C07D211/14 ,  C07D211/54 ,  C07D209/44 ,  C07D209/40 ,  C07D233/88 ,  C07D233/91 ,  C07D207/46 ,  C07D279/08 ,  C07D203/12 ,  C07D239/42 ,  C07D263/48 ,  C07D319/18 ,  C07D317/58 ,  C07D277/46 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P5/50 ,  A61P13/00 ,  A61P21/00 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P19/10 ,  A61P1/16 ,  A61P15/00 ,  C07C279/16 ,  C07C311/47 ,  C07C311/49 ,  C07C279/12 ,  C07C279/26 ,  C07C279/24 ,  C07C279/08 ,  C07C279/04 ,  C07C279/06 ,  C07D403/12 ,  C07D207/16

摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

公开(公告)号：US11427779B2

公开(公告)日：2022-08-30

申请号：US16480483

申请日：2018-01-05

申请人： SHOWA DENKO K.K.

发明人： Yuta Yamaguchi ,  Daisuke Yagyu ,  Naoya Fukumoto ,  Shoko Uetake ,  Tsuyoshi Kato ,  Hiroyuki Tomita ,  Ryuuta Miyasaka ,  Katsumi Murofushi

IPC分类号： C10M107/46 ,  G11B5/72 ,  G11B5/725 ,  C10N40/18 ,  C07D213/68 ,  C07D231/12 ,  C07D277/24 ,  C07D333/16 ,  C07D409/12 ,  C08G65/333 ,  C08G65/334 ,  C10M107/44

摘要： A fluorine-containing ether compound represented by Formula (1) is provided. R1—R2—CH2—R3—CH2—R4—R5   (1) (In Formula (1), R1 and R5 each represents a group having a heterocyclic ring and may be the same as or different from each other, R2 and R4 each represents a divalent linking group having a polar group and play be the same as or different from each other, and R3 represents a perfluoropolyether chain.)

公开(公告)号：US20210238192A1

公开(公告)日：2021-08-05

申请号：US17259673

申请日：2019-06-27

申请人： Blade Therapeutics, Inc.

发明人： Brad Owen Buckman ,  Prabha Ibrahim ,  Shendong Yuan ,  Kumaraswamy Emayan ,  Marc Adler

IPC分类号： C07D495/04 ,  A61P19/04 ,  C07C233/88 ,  C07D235/06 ,  C07D235/18 ,  C07C271/28 ,  C07C233/25 ,  C07D317/64 ,  C07C311/18 ,  C07D277/24 ,  C07D233/64 ,  C07D239/26 ,  C07C217/46 ,  C07D271/06 ,  C07C211/35 ,  C07C211/27 ,  C07C237/30 ,  C07D263/32 ,  C07D231/12 ,  C07D257/04 ,  C07D333/16 ,  C07C233/36 ,  C07D209/08 ,  C07D249/06 ,  C07D233/22 ,  C07D249/08 ,  C07C275/40 ,  C07C275/28 ,  C07D401/04

摘要： Disclosed herein are small molecule Vascular Adhesion Protein-1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

公开(公告)号：US11058696B2

公开(公告)日：2021-07-13

申请号：US16879824

申请日：2020-05-21

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  John L. Gilmore ,  Michael G. Yang ,  Zili Xiao ,  David Marcoux

IPC分类号： A61K31/695 ,  C07F7/08 ,  A61K31/135 ,  C07D215/14 ,  C07D241/04 ,  C07C323/29 ,  C07C251/38 ,  C07C251/42 ,  C07C251/44 ,  C07D209/46 ,  C07D213/38 ,  C07C275/26 ,  C07C217/74 ,  C07C323/25 ,  C07C235/46 ,  C07F9/54 ,  C07F9/572 ,  C07F9/09 ,  C07C215/42 ,  C07C217/52 ,  C07C217/58 ,  C07C219/24 ,  C07C233/41 ,  C07C233/65 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C271/34 ,  C07C317/28 ,  C07C317/32 ,  C07C321/16 ,  C07C321/22 ,  C07C321/28 ,  C07D213/32 ,  C07D213/69 ,  C07D213/70 ,  C07D215/12 ,  C07D217/24 ,  C07D231/12 ,  C07D231/20 ,  C07D239/26 ,  C07D241/12 ,  C07D277/24 ,  C07D305/08 ,  C07D309/06 ,  C07D309/12 ,  C07D311/58 ,  C07D311/76 ,  C07D319/20 ,  C07D333/16 ,  C07F9/117 ,  C07F9/62 ,  C07F9/6503 ,  C07F9/6509 ,  C07F9/655 ,  C07F9/6553 ,  A61K31/137 ,  A61K31/15 ,  A61K31/165 ,  A61K31/166 ,  A61K31/17 ,  A61K31/222 ,  A61K31/24 ,  A61K31/27 ,  A61K31/337 ,  A61K31/351 ,  A61K31/352 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/661

摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20210188758A1

公开(公告)日：2021-06-24

申请号：US17196873

申请日：2021-03-09

申请人： vTv Therapeutics LLC

发明人： Per SAUERBERG ,  Pavel PIHERA ,  Zdenek POLIVKA ,  Miroslav HAVRANEK ,  Ingrid PETTERSSON ,  John Patrick MOGENSEN

IPC分类号： C07C69/736 ,  A61K31/5375 ,  A61K31/415 ,  C07C59/70 ,  C07C217/48 ,  C07C323/16 ,  C07C323/32 ,  C07D211/46 ,  C07D213/30 ,  C07D231/12 ,  C07D295/096 ,  C07D307/79 ,  C07D333/16 ,  C07D333/54 ,  C07D265/30 ,  C07D213/36 ,  C07D295/112 ,  C07D307/81 ,  C07D333/20 ,  A61K31/192 ,  A61K31/195 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5377

摘要： Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.