Poly(ethylene glycol) derivatives with proximal reactive groups
    1.
    发明授权
    Poly(ethylene glycol) derivatives with proximal reactive groups 有权
    具有近端反应性基团的聚(乙二醇)衍生物

    公开(公告)号:US07714088B2

    公开(公告)日:2010-05-11

    申请号:US12410438

    申请日:2009-03-24

    摘要: An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent.

    摘要翻译: 提供活化的,基本上水溶性的聚(乙二醇),其具有直链或支链的聚(乙二醇)主链和至少一个通过水解稳定键连接至主链的末端,其中末端是支链的并具有近端反应性 团体 游离反应性基团能够与生物活性剂如蛋白质或肽中的活性部分反应,从而在活化的(聚乙二醇)与生物活性剂之间形成共轭物。

    Bio-based polyol
    3.
    发明授权
    Bio-based polyol 有权
    生物基多元醇

    公开(公告)号:US08349980B2

    公开(公告)日:2013-01-08

    申请号:US12710632

    申请日:2010-02-23

    摘要: A polyol having a substituent of formula (I) attached via a carbon-carbon single bond to a saturated carbon atom in a fatty acid hydrocarbyl group; wherein R1 and R2 are esterified residues of aliphatic or cycloaliphatic diols; and from 0 to 15 wt % of esterified residues of at least one C4-C12 anhydride, C4-C12 diacid or C4-C12 lactone, not including units of formula (I) attached to a fatty acid hydrocarbyl group.

    摘要翻译: 具有通过碳 - 碳单键连接到脂肪酸烃基中的饱和碳原子的式(I)的取代基的多元醇; 其中R1和R2是脂族或脂环族二醇的酯化残基; 和0至15重量%的至少一种C 4 -C 12酸酐,C 4 -C 12二酸或C 4 -C 12内酯的酯化残基,不包括连接到脂肪酸烃基上的式(I)单元。

    Hydrophilic composition and hydrophilic member
    6.
    发明申请
    Hydrophilic composition and hydrophilic member 审中-公开
    亲水组合物和亲水性成分

    公开(公告)号:US20070149742A1

    公开(公告)日:2007-06-28

    申请号:US11603190

    申请日:2006-11-22

    IPC分类号: C08F122/00

    摘要: A hydrophilic composition containing (A) a hydrophilic polymer having a structural unit represented by the following formula (I-b) and having a functional group represented by the following formula (I-a) at a terminal end of the polymer chain, and (B) an alkoxide compound containing an element selected from Si, Ti, Zr and Al, and a hydrophilic member having a hydrophilic film formed, on a substrate, by forming a film of the hydrophilic composition and heating and drying the same. Formula (I-a) Formula (I-b) In the formulae, R1 to R4 each represent a hydrogen atom or a hydrocarbon group having 8 or less carbon atoms; m represents 0, 1, or 2; Y represents a bivalent connection group having, for example, —CO2— or —NHCO—; L represents a single bond or an n-valent organic connection group; n represents an integer of 1 to 4; and A represents a hydrophilic group.

    摘要翻译: 一种亲水性组合物,其包含(A)具有由下式(Ib)表示的结构单元并且在聚合物链的末端具有由下式(Ia)表示的官能团的亲水性聚合物的亲水性组合物,和(B)醇盐 含有选自Si,Ti,Zr和Al的元素的化合物,以及在基材上形成亲水性膜的亲水性构件,通过形成亲水性组合物的膜并加热并干燥。 式(I-a)式(I-b)在式中,R 1至R 4各自表示氢原子或碳原子数为8以下的烃基; m表示0,1或2; Y表示具有例如-CO 2 - 或-NHCO-的二价连接基团; L表示单键或n价有机连接基团; n表示1〜4的整数, A表示亲水基团。

    Production of polymer compounds between polyester and diamine, a polymer compound and a structure including thereof
    7.
    发明申请
    Production of polymer compounds between polyester and diamine, a polymer compound and a structure including thereof 审中-公开
    聚酯与二胺之间的高分子化合物的制备,高分子化合物及其结构

    公开(公告)号:US20040214959A1

    公开(公告)日:2004-10-28

    申请号:US10808352

    申请日:2004-03-25

    发明人: Seiko Nakano

    摘要: A novel method for producing polyamide and/or polyester-amide copolymer is provided. The method of the present invention comprises the steps of: providing particles of the polyester, the polyester having pores extending from a surface of the particle to inside thereof; mixing the porous polyester with the diamine; and heating the mixture to the temperature not lower than a melting point of the diamine and not higher than a significant temperature of the polyester to cause reaction between the polyester and the diamine.

    摘要翻译: 提供了一种生产聚酰胺和/或聚酯 - 酰胺共聚物的新方法。 本发明的方法包括以下步骤:提供聚酯的颗粒,所述聚酯具有从颗粒的表面延伸到其内部的孔; 将多孔聚酯与二胺混合; 并将混合物加热到不低于二胺的熔点的温度,并且不高于聚酯的显着温度,以引起聚酯和二胺之间的反应。

    POLY[ALPHA-CYANOACRYLATE] HYDROLYZATE AND PREPARATION METHOD AND APPLICATION THEREOF

    公开(公告)号:US20220332862A1

    公开(公告)日:2022-10-20

    申请号:US17640480

    申请日:2020-08-21

    发明人: Junping WANG Yin GUO

    摘要: The invention relates to a poly[α-cyanoacrylate] hydrolyzate, a preparation method and an application thereof, belonging to the field of pharmaceutical and chemical industry. A main technical solution is as follows: provided is a poly[α-cyanoacrylate] hydrolyzate having a chemical formula: CH2—CRCOOHn, wherein R=—CN or —COOH. Poly[2-cyanoacrylic acid] provided by the present invention is dispersed in water to prepare the negatively charged microsphere, that is, to obtain the new blank embolic microsphere, the particle size of the microsphere can be adjusted in a micron-scale range, and the microsphere have a deformation function to pass through a vascular with a specific shape, which can tightly embolize the vascular to avoid ectopic embolism caused by falling off; poly[2-carboxyacrylic acid] can be used for preparing a new nano-drug carrier, improving the curative effect of the carried drug on diseased tissues and reduce the toxic and side effects of the carried drug on normal tissues.