公开(公告)号：US12110283B2

公开(公告)日：2024-10-08

申请号：US17372029

申请日：2021-07-09

申请人： VisEn Medical, Inc.

发明人： Kevin Groves ,  Bagna Bao

IPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/00 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/01 ,  C09B23/08 ,  G01N21/64 ,  G01N33/58

CPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/0008 ,  C09B23/0033 ,  C09B23/083 ,  C09B23/086 ,  G01N21/6458 ,  G01N33/582 ,  G01N2333/988 ,  Y02A50/30

摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

公开(公告)号：US12043619B2

公开(公告)日：2024-07-23

申请号：US16499700

申请日：2018-04-03

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Ellen M. Sletten ,  Timothy M. Swager ,  Justin Caram

IPC分类号： C07D411/10 ,  C07D311/62 ,  C07D311/68 ,  C07D405/06 ,  C07D405/10 ,  C07D407/06 ,  C07D407/10 ,  C09B23/01 ,  C09B23/04 ,  C09B23/06 ,  C09B23/08

CPC分类号： C07D411/10 ,  C07D311/62 ,  C07D311/68 ,  C07D405/06 ,  C07D405/10 ,  C07D407/06 ,  C07D407/10 ,  C09B23/0016 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B23/083

摘要： Near infrared and shortwave infrared dyes can have polymethine structures.

公开(公告)号：US20240077475A1

公开(公告)日：2024-03-07

申请号：US18489653

申请日：2023-10-18

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Matthew S. BOGYO ,  Martijn VERDOES ,  Leslie OFORI ,  Nimali P. WITHANA

IPC分类号： G01N33/532 ,  C07D403/14 ,  C07K5/065 ,  C09B23/01 ,  C09B23/08 ,  G01N33/58

CPC分类号： G01N33/532 ,  C07D403/14 ,  C07K5/06078 ,  C09B23/0066 ,  C09B23/086 ,  G01N33/582

摘要： Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.

公开(公告)号：US11905390B2

公开(公告)日：2024-02-20

申请号：US16703862

申请日：2019-12-05

申请人： FUJIFILM Corporation

发明人： Daisuke Sasaki ,  Yoshihiro Jimbo

IPC分类号： C08K5/00 ,  C09B23/01 ,  C08J3/20

CPC分类号： C08K5/0041 ,  C08J3/203 ,  C09B23/0066

摘要： An embodiment of the present invention is to provide a resin composition including a near infrared absorbing coloring agent represented by Formula (1) and a resin, a resin molded article, and a method of producing a resin molded article. In Formula (1), a ring A and a ring B each independently represent an aromatic ring or a heteroaromatic ring, XA and XB each independently represent a monovalent substituent, GA and GB each independently represent a monovalent substituent, kA represents an integer of 0 to nA, kB represents an integer of 0 to nB, nA represents the largest integer of GA which may be substituted in the ring A, nB represents the largest integer of GB which may be substituted in the ring B, XA and GA, and XB and GB may be respectively bonded to one another to form a ring, and in a case where a plurality of GA's and GB's are present, the plurality of GA's and the plurality of GB's may be respectively bonded to one another to form a ring structure.

公开(公告)号：US11858911B2

公开(公告)日：2024-01-02

申请号：US17674200

申请日：2022-02-17

申请人： Samsung Electronics Co., Ltd.

发明人： Moon Gyu Han ,  Kyung Bae Park ,  Dongseon Lee ,  Yong Wan Jin ,  Chul Joon Heo

IPC分类号： C07D401/14 ,  C09B57/00 ,  G02B5/20 ,  G02B5/22 ,  C09B23/00 ,  C07C211/54 ,  C07D401/04 ,  C07D403/04 ,  C09B23/01 ,  H04N23/57 ,  H10K85/60 ,  H01L27/146 ,  H10K39/32

CPC分类号： C07D401/14 ,  C07C211/54 ,  C07D401/04 ,  C07D403/04 ,  C09B23/0066 ,  C09B57/007 ,  G02B5/208 ,  G02B5/223 ,  H04N23/57 ,  H10K85/631 ,  H10K85/633 ,  H10K85/636 ,  H10K85/654 ,  H10K85/655 ,  H10K85/657 ,  H10K85/6572 ,  H01L27/14621 ,  H10K39/32

摘要： A squarylium compound has high transmittance in a visible wavelength spectrum of light and is configured to selectively absorb light in an infrared/near infrared wavelength spectrum of light.

公开(公告)号：US20230384496A1

公开(公告)日：2023-11-30

申请号：US18366402

申请日：2023-08-07

申请人： FUJIFILM Corporation

发明人： Hiroki KUWAHARA

IPC分类号： G02B5/22 ,  C09B23/01 ,  C09B57/00

CPC分类号： G02B5/223 ,  C09B23/0008 ,  C09B57/00

摘要： An optical member for use in a display device having a specific light emitting unit, which includes a specific light bending part and a light absorbing part having an absorption waveform selected from specific absorption waveforms A to D and having absorption waveform B: a specific absorption waveform in which two wavelengths that give an absorbance of half of an absorption maximum are present in a wavelength range larger than λBMax (a maximum emission wavelength exhibited by blue emission of the display device) and smaller than λGMax (a maximum emission wavelength exhibited by green emission of the display device) or C: a specific absorption waveform in which two wavelengths that give an absorbance of half of an absorption maximum are present in a wavelength range larger than λGMax and smaller than λRMax (a maximum emission wavelength exhibited by red emission of the display device).

公开(公告)号：US11801703B2

公开(公告)日：2023-10-31

申请号：US16909828

申请日：2020-06-23

申请人： CANON KABUSHIKI KAISHA

发明人： Takeshi Sekiguchi ,  Akiko Kitao ,  Ai Hayakawa

IPC分类号： B41M5/392 ,  B41M5/388 ,  B41M5/385 ,  C09B29/036 ,  C09B23/01 ,  C09B23/04

CPC分类号： B41M5/392 ,  B41M5/388 ,  B41M5/3854 ,  B41M2205/06 ,  B41M2205/30 ,  C09B23/0091 ,  C09B23/04 ,  C09B29/0048

摘要： A heat sensitive transfer sheet that achieves high optical density and high light resistance without generating scumming. The heat sensitive sheet has a base material and a coloring material layer formed on the base material, and the coloring material layer includes a compound represented by the following formula (1) and a particular dye compound:




wherein

R11 and R13 each independently represent a hydrogen atom, an alkyl group, an aralkyl group, an unsubstituted aryl group or an aryl group having a substituent; and

R12 and R14 to R18 each independently represent a hydrogen atom or an alkyl group.

公开(公告)号：US20230152327A1

公开(公告)日：2023-05-18

申请号：US17876349

申请日：2022-07-28

申请人： Becton, Dickinson and Company

发明人： Glenn Bartholomew ,  Yongchao Liang ,  Brian Wall ,  David Michel Moureau ,  Jonathan Hollinger

IPC分类号： G01N33/58 ,  C09B23/01

CPC分类号： G01N33/582 ,  C09B23/0075

摘要： Water-soluble dipyrromethene-based dyes are provided herein. In certain cases, the water-soluble dye is a dipyrromethene-boron dye. Embodiments of the subject water-soluble dipyrromethene-based dyes have a narrow absorption maxima in the yellow green range close to or at the 561 nm laser line, and are suitable for use in tandem dye systems. Embodiments of the subject dyes efficiently transfer energy to an acceptor chromophore while a second dipyrromethene-based dye of the same or different chemical structure is within energy-receiving proximity therewith. Also provided herein are tandem dyes that include the subject water-soluble dipyrromethene-based dyes, e.g., as donor chromophores. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

公开(公告)号：US20230135347A1

公开(公告)日：2023-05-04

申请号：US17930381

申请日：2022-09-07

申请人： ProLynx LLC

发明人： Gary W. ASHLEY ,  Daniel V. SANTI ,  Jeffrey C. HENISE

IPC分类号： A61K47/34 ,  A61K47/61 ,  A61K47/69 ,  A61K47/60 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L27/54 ,  A61L27/58 ,  C07C317/18 ,  C08J3/075 ,  G02F1/361 ,  C09B23/01 ,  A61K47/50 ,  A61K9/06 ,  A61K47/30 ,  A61L15/26 ,  A61L27/18 ,  A61L27/52 ,  C07C271/08

摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

公开(公告)号：US11518833B2

公开(公告)日：2022-12-06

申请号：US17157195

申请日：2021-01-25

申请人： FUJIFILM Corporation

发明人： Tokihiko Matsumura ,  Daisuke Sasaki ,  Kyohei Arayama ,  Yoshihiro Jimbo ,  Kazuya Oota ,  Keisuke Arimura ,  Takahiro Okawara

IPC分类号： C08F220/18 ,  C08F2/48 ,  C08K5/55 ,  C08L33/10 ,  C09B23/01 ,  C09B23/08 ,  C09B23/14 ,  C09B57/00 ,  G02B5/20 ,  G02B5/22 ,  G03F7/16 ,  G03F7/20 ,  G03F7/32 ,  G03F7/38 ,  H01L27/146 ,  H01L27/148 ,  G03F7/00 ,  G03F7/027 ,  G03F7/031 ,  G03F7/075 ,  C08F220/14 ,  C08K5/00 ,  C08K5/3415 ,  C09B23/00 ,  C09K3/00 ,  G03F7/033

摘要： A composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.