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公开(公告)号：US12044665B2
公开(公告)日：2024-07-23
申请号：US17375913
申请日：2021-07-14
发明人： Richard Petroski , Rachel Nelson
CPC分类号： G01N31/221 , G01N1/4055 , G01N21/80 , G01N33/24 , G01N2001/4061 , G01N2001/4088 , G01N2033/245
摘要： Compositions for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. Test methods for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. A multichamber cartridge containing two or more of the compositions in separate chambers.
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2.发明公开公开(公告)号：US20240232872A1
公开(公告)日：2024-07-11
申请号：US18581961
申请日：2024-02-20
申请人： FuelTrust, Inc.
发明人： Jonathan Arneault , Marco Cova
IPC分类号： G06Q20/38 , G01N31/00 , G06F16/27 , G06F40/295 , G06N3/00 , G06N5/00 , G06Q10/08 , G06Q20/40 , G16C20/20 , G16C20/30 , G16C20/70 , G16C20/90
CPC分类号： G06Q20/3825 , G01N31/00 , G06F16/27 , G06F40/295 , G06N3/00 , G06N5/00 , G06Q10/08 , G06Q20/389 , G06Q20/4014 , G16C20/20 , G16C20/30 , G16C20/70 , G16C20/90
摘要： The present disclosure describes a technology platform for creating and updating records of resources in a ledger. To create a record, a tenant organization may prepare a record to write to the ledger that may be flagged as temporary. Metadata may be added to the record, which flags the record as temporary. The metadata may comprise a unique code and an identification of a user that can approve the temporary record. The unique code and the identification may be sent, by the technology platform, to a device associated with one or more approving devices. Upon receiving the code and the identification of the transaction, the device may sign the unique code and invoke a routine based on the identification. The routine may fetch the temporary record. The device may compare the unique code to a code stored in the metadata of the temporary record. Upon valid verification of the unique code, the device may indicate authorization of the write. Based on the authorization, a proxy node associated with the technology platform may write a definitive record to the ledger based on the temporary record.
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公开(公告)号：US12025615B2
公开(公告)日：2024-07-02
申请号：US16647434
申请日：2018-09-13
发明人： Stephen Johnston
IPC分类号： G01N31/00 , C07K16/28 , G01N33/53 , G01N33/543 , G01N33/574 , G16B40/00 , G16H10/40 , G16H20/00 , G16H50/00 , G16H50/20 , G16H50/30 , G16H50/70 , C07K14/705 , G16H10/60
CPC分类号： G01N33/574 , C07K16/2818 , C07K16/2827 , G01N33/543 , G16B40/00 , G16H10/40 , G16H20/00 , G16H50/00 , G16H50/20 , G16H50/30 , G16H50/70 , C07K14/70503 , C07K14/70521 , C07K16/2803 , C07K2317/76 , G01N2800/52 , G01N2800/60 , G16H10/60
摘要： Provided herein are methods for classifying how a subject having a cancer will respond to immunotherapeutic (IT) therapy based on the subject's immunosignature or frameshift signature. Also provided herein are methods for classifying a subject having a cancer as having a good prognosis or a poor prognosis based on the subject's immunosignature or frameshift signature.
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公开(公告)号：US12019080B2
公开(公告)日：2024-06-25
申请号：US17409168
申请日：2021-08-23
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/70 , G16B40/00 , G16B40/20 , G16H50/20 , G01N2333/4703 , G01N2333/4745 , G01N2333/65 , G01N2333/8146 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56 , Y02A90/10
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.
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公开(公告)号：US11970680B2
公开(公告)日：2024-04-30
申请号：US16089220
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US11961595B2
公开(公告)日：2024-04-16
申请号：US16965222
申请日：2019-01-30
申请人： SRI INTERNATIONAL
摘要： Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.
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公开(公告)号：US11874282B2
公开(公告)日：2024-01-16
申请号：US16110687
申请日：2018-08-23
CPC分类号： G01N33/689 , G01N33/6893 , G16B20/00 , G16B25/10 , G16B99/00 , G01N2333/4703 , G01N2333/4745 , G01N2800/368 , G01N2800/52 , G01N2800/60
摘要： The present disclosure relates to a method for diagnosing preeclampsia or a preeclampsia-related condition in a pregnant subject. The method is based on the measurement of the amount of the biomarker IGFBP-7 (Insulin-like Growth Factor Binding Protein 7) in a sample from the subject and on the comparison of the measured amount to a reference. Also disclosed are methods for assessing the severity of preeclampsia or a preeclampsia-related condition and methods for monitoring a preeclampsia or a preeclampsia-related condition in a pregnant subject. The present disclosure further relates to the use of the biomarker IGFBP-7 or of an agent that specifically binds to IGFBP-7 in a sample from a pregnant subject for diagnosing, for monitoring or for assessing the severity of preeclampsia or a preeclampsia-related condition. Finally, the present disclosure relates to a device or kit adapted to carry out the method of the present invention.
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公开(公告)号：US11851646B2
公开(公告)日：2023-12-26
申请号：US16048695
申请日：2018-07-30
CPC分类号： C12N15/1003 , G01N1/286 , G01N2001/2866
摘要： A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises:
(a) phenol in an amount of more than 50% by volume based on the total amount of the solution;
(b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution;
(c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution;
(d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and
(e) a buffer for maintaining the pH of the solution at 4 to 6.-
公开(公告)号：US11839858B1
公开(公告)日：2023-12-12
申请号：US17196587
申请日：2021-03-09
申请人： Zee Company I, LLC
IPC分类号： A23L3/3454 , B01F23/40 , A23B4/12 , G01N31/00 , A23L3/3508 , A61L2/18 , B01F35/21 , B01F35/22 , B01F101/48
CPC分类号： B01F23/49 , A23B4/12 , A23L3/3508 , A61L2/18 , B01F35/2132 , B01F35/2202 , G01N31/00 , A23V2002/00 , B01F23/483 , B01F2101/48
摘要： A system and related methods for monitoring and dosing peroxycarboxylic acids, particularly peracetic acid, in food processing applications based upon desired concentration of the processing solution. The concentration of the peroxycarboxylic acid measured and additional peroxycarboxylic acid being added to the processing solution if the measured concentration is below a threshold level of the desired concentration, and additional water being added to the processing solution if the measured concentration is above a threshold level of the desired concentration. The system and related methods capable of being used in utilized with either live stream or static, storage tank based systems, to keep the concentration of peroxycarboxylic acid at or near desired concentration levels while experiencing less variation than experienced with conventional flow-based or hand-mixed systems.
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公开(公告)号：US11774419B2
公开(公告)日：2023-10-03
申请号：US16855627
申请日：2020-04-22
CPC分类号： G01N31/22 , A24D3/0204 , A24D3/10 , G01N1/28
摘要： Provided herein are cellulose acetate tow bands having less than 0.1 wt. % titanium dioxide, wherein the content of titanium dioxide is measured by ashing and/or by titanium particle count density. Also provided herein is a method of measuring the titanium dioxide content of cellulose acetate tow by ashing. Also provided herein is a method for measuring the color of cellulose acetate tow.
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