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公开(公告)号：WO2013010082A3
公开(公告)日：2014-05-08
申请号：PCT/US2012046676
申请日：2012-07-13
Applicant: MICROBIOTIX INC , MOIR DONALD T , AIELLO DANIEL , PEET NORTON P , WILLIAMS JOHN D , TORHAN MATTHEW
Inventor： MOIR DONALD T , AIELLO DANIEL , PEET NORTON P , WILLIAMS JOHN D , TORHAN MATTHEW
IPC: C07D317/44 , C07D295/18 , C07D413/00
CPC classification number: C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12
Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia co!i, and Chlamydia spp. having such type III secretion systems.
Abstract translation: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属，志贺氏菌属，灵菌属，耶尔森氏菌属，肠道病原体和肠道侵袭性埃希氏菌属和衣原体属的感染。 具有这种III型分泌系统。
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公开(公告)号：WO2012037119A3
公开(公告)日：2014-03-27
申请号：PCT/US2011051389
申请日：2011-09-13
Applicant: MICROBIOTIX INC , BASU ARNAB , MILLS DEBRA M , WILLIAMS JOHN D , LI BING , PEET NORTON P , BOWLIN TERRY L
Inventor： BASU ARNAB , MILLS DEBRA M , WILLIAMS JOHN D , LI BING , PEET NORTON P , BOWLIN TERRY L
CPC classification number: C07C311/44 , A61K31/18
Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。
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公开(公告)号：WO2013010089A3
公开(公告)日：2013-03-07
申请号：PCT/US2012046693
申请日：2012-07-13
Applicant: MICROBIOTIX INC , MOIR DONALD T , AIELLO DANIEL , PEET NORTON P , WILLIAMS JOHN D , TORHAM MATTHEW
Inventor： MOIR DONALD T , AIELLO DANIEL , PEET NORTON P , WILLIAMS JOHN D , TORHAM MATTHEW
IPC: A61K31/235 , A61K31/16
CPC classification number: C07D471/04 , A61K31/165 , A61K31/275 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/4015 , A61K31/402 , A61K31/4184 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4741 , A61K45/06 , C07C235/20 , C07D207/27 , C07D215/06 , C07D217/12 , C07D235/26 , C07D311/58 , C07D317/58 , C07D319/08 , A61K2300/00
Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
Abstract translation: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属，志贺氏菌属，假单胞菌属，耶尔森氏菌属，肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。 具有这种III型分泌系统。
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公开(公告)号：WO2013010089A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046693
申请日：2012-07-13
Applicant: MICROBIOTIX, INC. , MOIR, Donald, T. , AIELLO, Daniel , PEET, Norton, P. , WILLIAMS, John, D. , TORHAM, Matthew
Inventor： MOIR, Donald, T. , AIELLO, Daniel , PEET, Norton, P. , WILLIAMS, John, D. , TORHAM, Matthew
IPC: A61K31/4741
CPC classification number: C07D471/04 , A61K31/165 , A61K31/275 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/4015 , A61K31/402 , A61K31/4184 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4741 , A61K45/06 , C07C235/20 , C07D207/27 , C07D215/06 , C07D217/12 , C07D235/26 , C07D311/58 , C07D317/58 , C07D319/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
Abstract: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
Abstract translation: 公开了显示抑制由细菌III型分泌系统介导的效应器毒素分泌或移位的能力的有机化合物。 所公开的III型分泌系统抑制剂化合物可用于对抗由革兰氏阴性菌如沙门氏菌，福氏志贺氏菌，假单胞菌属，耶尔森氏菌属，肠致病性和肠侵袭性大肠杆菌和衣原体属感染的感染。 有这样的III型分泌系统。
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公开(公告)号：WO2007124113A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/009760
申请日：2007-04-19
Applicant: NEOCONIX, INC. , DITTMANN, Larry E. , WILLIAMS, John D. , LONG, William B. , CHEN, Tingbao
Inventor： DITTMANN, Larry E. , WILLIAMS, John D. , LONG, William B. , CHEN, Tingbao
IPC: H01R12/24
Abstract: The present invention provides a clamp with spring contact elements to receive and secure a flat flex cable with exposed electrical traces to an electrical circuit such as on a printed circuit board. The clamp of the present invention has features for enhanced registration and alignment of exposed electrical traces on the flat flex cable to the spring contact elements in the clamp. Another aspect of the invention is the ability to connect high density contact arrays within the clamp to a circuit board via an array of contact pads on the opposite side of the substrate on which the spring contact elements are disposed. One exemplary application of the present invention is to connect a camera module in a cell phone to a printed circuit board or like electrical device in the phone.
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Patent Agency Ranking6.发明申请CLAMP WITH SPRING CONTACTS TO ATTACH FLAT FLEX CABLE (FFC) TO A CIRCUIT BOARD 审中-公开带弹簧联接器的夹紧装置将平面柔性电缆（FFC）连接到电路板
公开(公告)号：WO2007124113A2
公开(公告)日：2007-11-01
申请号：PCT/US2007009760
申请日：2007-04-19
Applicant: NEOCONIX INC , DITTMANN LARRY E , WILLIAMS JOHN D , LONG WILLIAM B , CHEN TINGBAO
Inventor： DITTMANN LARRY E , WILLIAMS JOHN D , LONG WILLIAM B , CHEN TINGBAO
IPC: H01R12/24
CPC classification number: H01R12/716 , H01R12/721 , H01R12/775 , H01R12/88
Abstract: The present invention provides a clamp with spring contact elements to receive and secure a flat flex cable with exposed electrical traces to an electrical circuit such as on a printed circuit board. The clamp of the present invention has features for enhanced registration and alignment of exposed electrical traces on the flat flex cable to the spring contact elements in the clamp. Another aspect of the invention is the ability to connect high density contact arrays within the clamp to a circuit board via an array of contact pads on the opposite side of the substrate on which the spring contact elements are disposed. One exemplary application of the present invention is to connect a camera module in a cell phone to a printed circuit board or like electrical device in the phone.
Abstract translation: 本发明提供了一种具有弹簧接触元件的夹具，用于接收并固定具有暴露的电迹线的扁平柔性电缆到诸如印刷电路板上的电路。 本发明的夹具具有用于增强平坦柔性电缆上的暴露的电迹线与夹具中的弹簧接触元件的对准和对准的特征。 本发明的另一方面是通过在其上布置有弹簧接触元件的基板的相对侧上的接触焊盘阵列将夹具内的高密度接触阵列连接到电路板的能力。 本发明的一个示例性应用是将手机中的相机模块连接到电话中的印刷电路板或类似电气设备。
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公开(公告)号：WO2007056169A3
公开(公告)日：2007-10-11
申请号：PCT/US2006043000
申请日：2006-11-03
Applicant: NEOCONIX INC , WILLIAMS JOHN D
Inventor： WILLIAMS JOHN D
IPC: H05K1/00
CPC classification number: H05K1/118 , H01R12/526 , H01R13/2407 , H05K3/202 , H05K3/326 , H05K3/4092 , H05K3/42 , H05K2201/0311 , H05K2201/0397 , H05K2201/10378 , H05K2203/1572 , Y10T29/49156 , Y10T29/49204 , Y10T29/49218 , Y10T29/49222
Abstract: A compliant, scalable, thermal-electrical-mechanical, flexible electrical connector. In one configuration, the flexible electrical connector comprises a flexible substrate, a first and second conductive layer, and a plating contiguously applied over the conductive layers and holes through the substrate. The first and second conductive layers are adhered to opposite sides of the flexible substrate and have a plurality of raised contact elements in registration with at least a subset of the holes. At least some contact elements on the first and second conductive layers that oppose each other are in electrical communication with one another by way of the plating.
Abstract translation: 兼容，可扩展，热电机械，柔性电连接器。 在一种配置中，柔性电连接器包括柔性基板，第一和第二导电层以及连续施加在导电层上的电镀层和通过基板的孔。 第一和第二导电层粘附到柔性基板的相对侧上，并且具有多个与至少一个孔的子集对准的凸起接触元件。 第一和第二导电层上彼此相对的至少一些接触元件通过电镀彼此电连通。
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公开(公告)号：WO2004112451A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/018408
申请日：2004-06-10
Applicant: EPIC TECHNOLOGY INC. , BROWN, Dirk, D. , WILLIAMS, John, D. , YAO, Hongjun , ALI, Hassan, O.
Inventor： BROWN, Dirk, D. , WILLIAMS, John, D. , YAO, Hongjun , ALI, Hassan, O.
IPC: H05K7/10
CPC classification number: H01R12/714 , H01L23/32 , H01L24/72 , H01L2924/01004 , H01L2924/01005 , H01L2924/01029 , H01L2924/01033 , H01L2924/01079 , H01L2924/01082 , H01L2924/01087 , H01L2924/10253 , H01L2924/14 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/30107 , H01L2924/3011 , H01L2924/3025 , H01R12/52 , H01R13/03 , H01R13/2407 , H01R43/007 , H01R43/205 , H05K3/326 , H05K3/4092 , H05K7/1069 , H01L2924/00
Abstract: An electrical connector for electrically connecting to pads of a land grid array formed on an electronic component includes a dielectric layer including opposing first and second surfaces, and a multiple number of contact elements extending above the first surface of the dielectric layer. Each contact element includes a conductive portion disposed to engage a respective pad of the land grid array for providing electrical connection to the land grid array. In particular, the multiple number of contact elements includes a first contact element and a second contact element whereby the first contact element has an operating property different than an operating property of the second contact element. In one embodiment, the operating property includes a mechanical or an electrical property. For example, the first contact element can have a larger elasticity than the second contact element.
Abstract translation: 用于电连接到形成在电子部件上的焊盘栅格阵列的焊盘的电连接器包括包括相对的第一和第二表面的电介质层和在电介质层的第一表面上方延伸的多个接触元件。 每个接触元件包括设置成接合焊盘栅格阵列的相应焊盘的导电部分，用于提供与焊盘栅格阵列的电连接。 特别地，多个接触元件包括第一接触元件和第二接触元件，由此第一接触元件具有与第二接触元件的操作性能不同的操作特性。 在一个实施例中，操作属性包括机械或电气特性。 例如，第一接触元件可以具有比第二接触元件更大的弹性。
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公开(公告)号：WO2010056914A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064270
申请日：2009-11-12
Applicant: MICROBIOTIX, INC. , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , MOIR, Donald, T. , AIELLO, Daniel , BARNES, Marjorie, H. , WILLIAMS, John, D. , BISWAS, Subhasis, B.
Inventor： MOIR, Donald, T. , AIELLO, Daniel , BARNES, Marjorie, H. , WILLIAMS, John, D. , BISWAS, Subhasis, B.
CPC classification number: A61K31/35 , A01N43/16 , A01N43/52 , A01N43/707 , A01N43/82 , A61K45/06 , A61K2300/00
Abstract: Organic compounds are described that inhibit bacterial helicase activity and growth of bacterial cells on surfaces.
Abstract translation: 描述了抑制表面细菌解旋酶活性和细菌细胞生长的有机化合物。
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公开(公告)号：WO2009142720A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/003086
申请日：2009-05-19
Applicant: MICROBIOTIX, INC. , OPPERMAN, Timothy, J. , WILLIAMS, John, D. , PEET, Norton, P. , KHAN, Atiyya, R. , KWASNY, Steven, M.
Inventor： OPPERMAN, Timothy, J. , WILLIAMS, John, D. , PEET, Norton, P. , KHAN, Atiyya, R. , KWASNY, Steven, M.
IPC: A01N43/78
Abstract: Organic compounds are described for use in inhibiting or preventing formation of bacterial biofilms.
Abstract translation: 描述了用于抑制或预防细菌生物膜形成的有机化合物。
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