公开(公告)号：WO2007143540A9

公开(公告)日：2008-05-02

申请号：PCT/US2007070206

申请日：2007-06-01

Applicant: APPLERA CORP ,  SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

Inventor： SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

IPC: B01L3/02

CPC classification number: B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/6806 ,  Y10T436/2575

Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation or dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

Abstract translation: 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于在样品室中的生物样品的生物测试的生物样品。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道处于流动连通状态并被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修饰，其被配置为控制弯液面的运动，以便控制气泡形成或位于靠近入口通道的至少一些样品室内的干燥试剂，其与至少一些样品 室。

公开(公告)号：WO2007143540A2

公开(公告)日：2007-12-13

申请号：PCT/US2007/070206

申请日：2007-06-01

Applicant: APPLERA CORPORATION ,  SONG, Maengseok ,  YANG, Joon Mo ,  LEE, Julie C. ,  BEARD, Nigel P. ,  CHIANG, Yuh-min ,  TAN, Roy H. ,  SCHEMBRI, Carol

Inventor： SONG, Maengseok ,  YANG, Joon Mo ,  LEE, Julie C. ,  BEARD, Nigel P. ,  CHIANG, Yuh-min ,  TAN, Roy H. ,  SCHEMBRI, Carol

IPC: B01L3/02

CPC classification number: B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/6806 ,  Y10T436/2575

Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation or dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

Abstract translation: 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于在样品室中的生物样品的生物测试的生物样品。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道处于流动连通状态并被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修饰，其被配置为控制弯液面的运动，以便控制气泡形成或位于靠近入口通道的至少一些样品室内的干燥试剂，其与至少一些样品 室。

公开(公告)号：WO2006083094A1

公开(公告)日：2006-08-10

申请号：PCT/KR2006/000323

申请日：2006-01-27

Applicant: YANG, Joon Mo

Inventor： YANG, Joon Mo

IPC: A47L1/02

CPC classification number: B62D57/024 ,  B08B1/00 ,  B08B3/024 ,  B08B5/02 ,  B08B5/04 ,  E04G23/002

Abstract: The present invention relates to a surface-clinging type robot that has reduced weight and better mobility by employing the lowest number of adhering plates and that allows three-dimensional movement between a wall and a ceiling as well as typical two-dimensional movement. The robot has two adhering plates. The second adhering plate moves upward by a first up/down driving unit while the first adhering plate is in contact with a surface, and rotates on the first adhering plate by a first horizontal rotating unit. Then the second adhering plate moves downward by the first up/down driving unit, and clings to the surface by a clinging force supplied thereto.

Abstract translation: 本发明涉及一种表面贴附式机器人，其通过采用最少数量的粘合板并且允许壁与天花板之间的三维运动以及典型的二维运动来减轻重量和更好的移动性。 机器人有两个粘合板。 第一粘贴板通过第一上/下驱动单元向上移动，同时第一粘合板与表面接触，并且通过第一水平旋转单元在第一粘合板上旋转。 然后第二粘合板通过第一上/下驱动单元向下移动，并通过供给到其的附着力粘附到表面。

公开(公告)号：WO2009079052A2

公开(公告)日：2009-06-25

申请号：PCT/US2008/077092

申请日：2008-09-19

Applicant: APPLIED BIOSYSTEMS INC. ,  YANG, Joon Mo ,  LIU, David, M. ,  CHIANG, Yuh-Min ,  SCHEMBRI, Carol ,  LAU, Aldrich, N. K. ,  ULMANELLA, Umberto ,  BEARD, Nigel, P. ,  SHARIATI, Maryam ,  NURSE, James, C. ,  HAGA, Douwe, D. ,  HARDING, Ian, A. ,  FOCARACCI, Julio, P.

Inventor： YANG, Joon Mo ,  LIU, David, M. ,  CHIANG, Yuh-Min ,  SCHEMBRI, Carol ,  LAU, Aldrich, N. K. ,  ULMANELLA, Umberto ,  BEARD, Nigel, P. ,  SHARIATI, Maryam ,  NURSE, James, C. ,  HAGA, Douwe, D. ,  HARDING, Ian, A. ,  FOCARACCI, Julio, P.

IPC: B01L3/00 ,  C12Q1/68

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/1805 ,  B01L2300/1861 ,  B01L2400/0677

Abstract: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.

Abstract translation: 描述了用于隔离化验卡上的室的化验卡和装置以及方法。 测定卡包括由具有软化温度的一种或多种材料（例如塑料）形成的基底，基底限定与相应反应室连通的通道。 可以在通道的区域中将测定卡加热到至少软化温度。 软化的塑料可以变形，例如用可以或不可以提供软化基材的热量的工具。 以这种方式，可以使衬底的塑料至少部分地阻塞通道，从而隔离反应室。 本发明还涉及一种制造工具装置的方法，所述工具装置包括用于加热和使检定卡变形的销。

公开(公告)号：WO2006116616A3

公开(公告)日：2007-09-27

申请号：PCT/US2006016060

申请日：2006-04-26

Applicant: APPLERA CORP ,  YUE MIN ,  LIU DAVID M ,  CHIANG YUH-MIN ,  YANG JOON MO ,  LEHTO DENNIS ,  VANN CHARLES S ,  BEARD NIGEL P ,  HARDING IAN A ,  VAN CAMP JOHN ,  DROMARETSKY ALEXANDER ,  ERMAKOV SERGEY V ,  OLDHAM MARK F ,  ROY JOY ,  SHARIATI MARYAM ,  ULMANELLA UMBERTO

Inventor： YUE MIN ,  LIU DAVID M ,  CHIANG YUH-MIN ,  YANG JOON MO ,  LEHTO DENNIS ,  VANN CHARLES S ,  BEARD NIGEL P ,  HARDING IAN A ,  VAN CAMP JOHN ,  DROMARETSKY ALEXANDER ,  ERMAKOV SERGEY V ,  OLDHAM MARK F ,  ROY JOY ,  SHARIATI MARYAM ,  ULMANELLA UMBERTO

IPC: C12M1/38

CPC classification number: C12Q1/6806 ,  B01J2219/00317 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50853 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/048 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0694 ,  G01N35/028 ,  Y10T436/2575

Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括衬底的生物样品的系统，其中所述衬底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测兼容和测定相容的材料构成。

公开(公告)号：WO2006093366A1

公开(公告)日：2006-09-08

申请号：PCT/KR2005/000608

申请日：2005-03-04

Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION ,  YANG, Joon Mo ,  LEE, Chang Hoon ,  YI, Seung Ho ,  SHIN, Hak Soo ,  PARK, Sang Hyun ,  SOH, Kwang Sup

Inventor： YANG, Joon Mo ,  LEE, Chang Hoon ,  YI, Seung Ho ,  SHIN, Hak Soo ,  PARK, Sang Hyun ,  SOH, Kwang Sup

IPC: G01J1/02

CPC classification number: G01J1/02 ,  G01J1/0242 ,  G01J1/0252 ,  G01J1/044 ,  G01J1/0448

Abstract: The present invention relates to a photodetecting device protected from contamination by organic materials secreted from a living matter in the case that a photodetector is used for investigating characteristics of the living matter, and which easily blocks the influence of an external magnetic field. The photodetecting device includes a protection window formed in the front side facing a measured object, and a magnetic shielding tube providing a space for installing components of the photodetecting device such as a variable shutter, movable lens, protection window, and incidence window. Additionally, the photodetecting device according to the present invention includes a drive means enabling remote control of photodetector movement, and provides an advantage that a tester may measure various points of a specimen more easily.

Abstract translation: 本发明涉及在光检测器用于调查生物特性的情况下，保护有机材料分泌的有机材料免受污染的光检测装置，并且容易阻止外部磁场的影响。 光检测装置包括形成在面向测量对象的正面中的保护窗，以及提供用于安装诸如可变快门，可移动透镜，保护窗和入射窗等光电检测装置的部件的空间的磁屏蔽管。 此外，根据本发明的光电检测装置包括能够远程控制光电检测器运动的驱动装置，并且提供了测试者可以更容易地测量样本的各个点的优点。

公开(公告)号：WO2005022147A1

公开(公告)日：2005-03-10

申请号：PCT/US2004/028213

申请日：2004-08-27

Applicant: GENOPTIX, INC. ,  BUTLER, William, Frank ,  CHACHISVILIS, Mirianas ,  DEES, Robert ,  HAGEN, Norbert ,  MARCHAND, Philippe ,  RAYMOND, Daniel, E. ,  TU, Eugene ,  WANG, Mark, M. ,  YANG, Joon, Mo ,  YANG, Rong ,  ZHANG, Haichuan

Inventor： BUTLER, William, Frank ,  CHACHISVILIS, Mirianas ,  DEES, Robert ,  HAGEN, Norbert ,  MARCHAND, Philippe ,  RAYMOND, Daniel, E. ,  TU, Eugene ,  WANG, Mark, M. ,  YANG, Joon, Mo ,  YANG, Rong ,  ZHANG, Haichuan

IPC: G01N33/48

CPC classification number: G01N15/1459 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0454 ,  B01L2400/0487 ,  G01N2015/149 ,  Y10T436/2575

Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000 - 100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.

Abstract translation: 为微型荧光激活细胞分选器提供基于光学开关的装置和方法，用于通过微流体通道网络快速，主动地控制细胞路由。 该分选机能够对小数量细胞群进行低应激，高效分选（即1000-100,000个细胞）。 本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。

公开(公告)号：WO2010117457A3

公开(公告)日：2011-03-24

申请号：PCT/US2010001053

申请日：2010-04-08

Applicant: APPLIED BIOSYSTEMS LLC ,  LIU DAVID ,  YANG JOON MO ,  SHARIATI MARYAM ,  WOO SAM ,  COX DAVID M ,  LEHTO DENNIS

Inventor： LIU DAVID ,  YANG JOON MO ,  SHARIATI MARYAM ,  WOO SAM ,  COX DAVID M ,  LEHTO DENNIS

IPC: C12M1/38 ,  C12Q1/68

CPC classification number: B01F3/0807 ,  B01F7/161 ,  B01F7/22 ,  B01F2215/0422 ,  B01F2215/0431 ,  B01F2215/0481

Abstract: A system and method are provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions. A sample is retained in a pouch or flexible bag which permits bulk PCR amplification with efficient heat-transfer properties. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly.

Abstract translation: 提供适用于常规基于PCR的反应以及基于乳液的PCR反应的大体积样品扩增的系统和方法。 将样品保留在袋或柔性袋中，其允许具有有效的热传递性质的大量PCR扩增。 对于涉及基于乳液的PCR扩增的应用，该系统和方法提供了乳液扩增的改进的均匀性，并可用于快速和可重复地扩增大体积或小体积的乳液。

公开(公告)号：WO2011026128A3

公开(公告)日：2011-03-03

申请号：PCT/US2010/047377

申请日：2010-08-31

Applicant: LIFE TECHNOLOGIES CORPORATION ,  HIRANO, Kirk ,  ANDERSEN, Mark ,  GONG, Jian ,  WOO, Sam ,  COX, David ,  YANG, Joon Mo ,  YUE, Min ,  SHARIATI, Maryam ,  BRIDGHAM, John ,  LIU, David

Inventor： HIRANO, Kirk ,  ANDERSEN, Mark ,  GONG, Jian ,  WOO, Sam ,  COX, David ,  YANG, Joon Mo ,  YUE, Min ,  SHARIATI, Maryam ,  BRIDGHAM, John ,  LIU, David

IPC: B01J19/00 ,  B01L3/00 ,  G01N35/10

Abstract: Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.

公开(公告)号：WO2011026128A2

公开(公告)日：2011-03-03

申请号：PCT/US2010047377

申请日：2010-08-31

Applicant: LIFE TECHNOLOGIES CORP ,  HIRANO KIRK ,  ANDERSEN MARK ,  GONG JIAN ,  WOO SAM ,  COX DAVID ,  YANG JOON MO ,  YUE MIN ,  SHARIATI MARYAM ,  BRIDGHAM JOHN ,  LIU DAVID

Inventor： HIRANO KIRK ,  ANDERSEN MARK ,  GONG JIAN ,  WOO SAM ,  COX DAVID ,  YANG JOON MO ,  YUE MIN ,  SHARIATI MARYAM ,  BRIDGHAM JOHN ,  LIU DAVID

IPC: B01J19/00 ,  B01L3/00 ,  G01N35/10

CPC classification number: C12Q1/6869 ,  B01F13/0059 ,  B01F13/0222 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00466 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2400/0427 ,  C12Q1/6874 ,  G01N35/00069 ,  G01N35/1002 ,  G01N35/1097 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/1034 ,  G02B21/34 ,  Y10T436/11 ,  Y10T436/143333

Abstract: Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.

Abstract translation: 提供了各种流通池配置和系统以及制造和使用它们的方法。 流通池，系统和使用方法可用于进行测序反应和下一代测序方法。