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    BENZONORBORNENYL, BENZOPYRANYL AND BENZOTHIOPYRANYL RETINOIC ACID ANALOGUES
    22.
    发明申请
    BENZONORBORNENYL, BENZOPYRANYL AND BENZOTHIOPYRANYL RETINOIC ACID ANALOGUES 审中-公开
    苯并噻唑，苯并噻吩和苯并噻唑衍生物类似物

    公开(公告)号：WO1985000806A1

    公开(公告)日：1985-02-28

    申请号：PCT/US1984000280

    申请日：1984-02-24

    Applicant: SRI INTERNATIONAL

    Inventor： SRI INTERNATIONAL ,  DAWSON, Marcia, Ilton ,  CHAN, Rebecca, Leung-Shun ,  HOBBS, Peter, D.

    IPC: C07C69/78

    CPC classification number: C07D409/06 ,  C07C47/546 ,  C07C49/792

    Abstract: Compounds of the formulas (I), (II) and (III), where R , R , R and R are hydrogen or methyl, X is hydrogen or fluorine and Q is formula (IV), (V), (VI), (VII), (VIII), or (IX), and X is hydrogen, hydroxy, methoxy or fluorine, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy or NR R , where R is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl, and R is alkyl with 0 or 1 hydroxy substituent or aryl, with the provisos that X is fluorine only when R is methyl, when R or R is methyl the other R or R is also methyl and when Q is said thienyl group Q may be in either the cis or trans position. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

    Abstract translation: 式（I），（II）和（III）的化合物，其中R 1，R 2，R 3和R 4是氢或甲基，X是氢或氟，Q是式 （IV），（V），（VI），（VII），（VIII）或（IX），X 1是氢，羟基，甲氧基或氟，R是羟基，具有0或1个羟基取代基的烷氧基 ，芳氧基或NR 5 R 6，其中R 5是氢，具有0或1个羟基取代基或芳基的烷基，R 6是具有0或1个羟基取代基或芳基的烷基，条件是 只有当R 2为甲基时，X为氟，当R 3或R 4为甲基时，其它R 3或R 4也为甲基，当Q为所述噻吩基时，Q可以为 顺式或反式位置。 这些化合物可用作抑制上皮细胞中肿瘤促进和用于治疗非恶性皮肤病的化学预防剂。

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