摘要:
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β- amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.
摘要:
The invention relates to an oscillating conveyor (1), which comprises a support (2), a conveying element (3), that is arranged to carry objects to be moved and is supported by the support (2) in order to be displaced to and fro between a first extreme position and a second extreme position, and a driving means (4), which is arranged on the stand (2) in order to displace the conveying element (3) to and fro. A driving means (4) is arranged to displace the conveying element (3) relatively slowly to the first extreme position and to displace it relatively quickly to the second extreme position in order thereby to achieve a movement of the objects in a direction, which corresponds to a displacement direction of the conveying element from the second extreme position to the first extreme position. The driving means (4) includes a crank mechanism (5), which comprises a pendulum pin (15), which in relation to a rotational axis (7) of the crank mechanism (5) is mounted such that, when the crank (6) rotates, at the pendulum pin ( 15) an angle between the axis of rotation (7) and a first pivot pin (12) varies within an angular range being either obtuse or acute, resulting in the desired displacement of the conveying element (3) at different speeds to and fro, wherein the position of the pendulum pin (15) in relation to the rotational axis (7) is adjustable, thus enabling a variation of the displacement speed of the conveyor element (3).
摘要:
The invention relates to a laminate structure comprising a first electrically conducting surface, a second electrically conducting surface and a porous, continuous web impregnated in an electrochemically weakable adhesive provided between said first and second conducting surfaces. The invention further relates to a method of producing said laminate structure.
摘要:
The present invention concerns a device (14) adapted to be releasable attached to a blister (10) including at least one piece of medicament (13). The device (14) comprises means for releasable attachment to said blister (10) a sensor arrangement including at least one first sensor arranged to register the sound of the dispense of a piece of medicament (13), a time system arranged to register the time and/or date of the dispensing of said piece of medicament (13) and a memory for storing data, such as time and/or date data, related to the dispense of said piece of medicament.
摘要:
The invention relates to a laminate structure comprising a first carrier layer with a surface, a first active surface being electrically conducting and being supported by the first carrier layer, a second active surface being electrically conducting and being supported by the first carrier layer, wherein the first active surface is separated from the second active surface a first distance along the surface of the first carrier layer, wherein the laminate structure is adapted to receive an electrically weakable adhesive bridging said distance between the active surfaces. The invention further relates to a method of producing such a laminate structure.
摘要:
The invention relates to a laminate structure comprising a first active layer having a first electrode potential, a second active layer having a second electrode potential, wherein the second electrode potential being different from the first electrode potential and wherein the first and second active layers are arranged at a distance from each other, and wherein the laminate further comprises a third layer of an electrically weakable adhesive at least partly bridging said distance between the first and second layers.
摘要:
Dialysis machine for alternatively hospital care and self-care having a touch screen (16) which can be adjusted universally and to a desired vertical position on the dialysis machine and can be locked in the desired adjusted position. As a consequence thereof the touch screen can be arrested in a position in relation to the position of the person controlling the dialysis machine which allows the touch screen to be comfortably reached irrespective of the position of said person.
摘要:
Compounds of formula I are claimed wherein R 1 is hydrogen; C 1-3 alkyl, optionally substituted by one or more substituents independently selected from hydroxy, C 1-3 alkoxy andfluoro; C 1-3 alkoxy, optionally substituted by one or morefluoro; cyano; hydroxy or halo; m is 1,2 or 3; Het is C 5-6 heteroaryl substituted by 1 or 2 substituents R 2 ; R 2 is C 1-4 alkyl; C 1-4 haloalkyl;C 1-4 haloalkoxy; halo; C 1-4 alkoxy; or C 3-7 cycloalkyloxy, optionally substituted by one or morefluoro; D is C 5-6 heteroaryl; C 3-7 heterocycloalkyl; or C 3-7 cycloalkyl; wherein each D may optionally be substituted by one or more X4; X 4 is halo; or C 1-3 alkyl, optionally substituted by one or morefluoro; C 1-3 alkyl-O-C 1-3 alkyl, optionally substituted by one or morefluoro; C 1-3 alkoxy, optionally substituted by one or morefluoro; cyano; hydroxy; oxo; R 3 0(C=O); or R 4 (C=O); R 3 is C 1-4 alkyl; C 1-4 alkyl-O-C 1-4 alkyl; C 5-6 cycloalkyl; aryl; or aryl-C 1-2 alkyl; R 4 is C 1-4 alkyl; or C 5-6 heteroaryl; L 1 is C 1-4 alkylene; or a bond; and L 2 is C 1-3 alkylene. Compounds of the invention are useful in therapy, such as pain therapy.
摘要:
The present disclosure relates to a package comprising a top panel (C) , a bottom panel (A) , a first side panel (B) connecting the top panel (C) and the bottom panel (A) to each other and a second side panel (D, E) also connecting the top panel (C) and the bottom panel (A) to each other, wherein the bottom panel (A) , the first side panel (B) , the top panel (C) and the second side panel (D, E) form a sleeve (1) having a cross-section essentially formed as a rectangle, wherein the sleeve (1) is adapted to receive an insert (2) being slidable within said sleeve (1) along a sliding direction (N) being normal to said rectangle. The present disclosure also relates to a blank for forming said package .
摘要:
A drill primarily intended for ejector drilling is made of one single piece, in order to avoid unroundness that arises when welding and to avoid weld joint gaps in which a chip may easily get wedged. Moreover, the drill is provided with a turned-out chip space (13) in order to as far as possible avoid chip jamming. The inserts are preferably placed tangentially, which simplifies their mounting. In principle, the inserts are semi-circle formed and this simplifies both their pressing and the making of the insert pockets.