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公开(公告)号：WO2015186063A1
公开(公告)日：2015-12-10
申请号：PCT/IB2015/054174
申请日：2015-06-02
Applicant: NOVARTIS AG , REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
Inventor： REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
IPC: C07D471/04 , A61K31/44 , C07D471/14 , C07D495/14
CPC classification number: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4745 , A61K45/06 , C07D471/14 , C07D471/16 , C07D495/14 , A61K2300/00
Abstract: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义; 作为其制备，用作药物和包含它的药物。
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2.发明申请PYRIMIDO [4,5-B]QUINOLINE-4,5 (3H,10H)-DIONES AS NONSENSE MUTATION SUPPRESSORS 审中-公开吡咯并[4,5-B]喹啉-4,5（3H，10H） - 为非扩散抑制剂
公开(公告)号：WO2014091446A1
公开(公告)日：2014-06-19
申请号：PCT/IB2013/060859
申请日：2013-12-12
Applicant: NOVARTIS AG , JACOBY, Edgar , REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
Inventor： JACOBY, Edgar , REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
IPC: A61K31/513 , C07D471/04 , A61P21/00 , A61P7/00 , A61P35/00 , A61P43/00
CPC classification number: A61K31/519 , C07D471/04 , C07D471/14
Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物; 或其盐，其中取代基如说明书中所定义; 作为其制备，用作药物和包含它的药物。
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公开(公告)号：WO2007113276A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/053155
申请日：2007-04-02
Applicant: NOVARTIS AG , NOVARTIS PHARMA GmbH , GLATTHAR, Ralf , CARCACHE, David , SPANKA, Carsten , VRANESIC, Ivan-Toma , TROXLER, Thomas J.
Inventor： GLATTHAR, Ralf , CARCACHE, David , SPANKA, Carsten , VRANESIC, Ivan-Toma , TROXLER, Thomas J.
IPC: C07D401/04 , C07D471/04 , C07D487/04 , A61K31/55 , A61P25/00
CPC classification number: C07D401/04 , C07D471/04 , C07D487/04
Abstract: The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
Abstract translation: 本发明涉及式（I）的新型双芳基胺及其药学上可接受的前药，盐，溶剂合物，水合物和N-氧化物以及包含它们的药物组合物，其使用方法及其制备方法。
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公开(公告)号：WO2015186061A1
公开(公告)日：2015-12-10
申请号：PCT/IB2015/054172
申请日：2015-06-02
Applicant: NOVARTIS AG , REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
Inventor： REINHARDT, Juergen , SCHMIEDEBERG, Niko , SPANKA, Carsten
IPC: C07D471/04 , A61K31/38 , A61K31/505 , C07D495/14
CPC classification number: C07D471/04 , A61K31/519 , A61K45/06 , C07D495/14 , A61K2300/00
Abstract: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义; 作为其制备，用作药物和包含它的药物。
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5.发明申请5-SULFANYLMETHYL-[1,2,4] TRIAZOL[1, 5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS 审中-公开5-噻喃基甲基 - [1,2,4]三唑并[1,5-A]嘧啶-6-醇衍生物作为CXCR2拮抗剂
公开(公告)号：WO2008061741A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/010098
申请日：2007-11-21
Applicant: NOVARTIS AG , PRESS, Neil, John , PORTER, David , SPANKA, Carsten
Inventor： PRESS, Neil, John , PORTER, David , SPANKA, Carsten
IPC: C07D471/04 , A61K31/522 , A61P29/00
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
Abstract translation: 本发明涉及式（I）化合物和这些化合物作为药物的用途，例如， 在预防或治疗CXCR2受体介导的病症或疾病中。
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Patent Agency Ranking
公开(公告)号：WO2007025709A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006008426
申请日：2006-08-29
Applicant: NOVARTIS AG , NOVARTIS PHARMA GMBH , FLOR PETER JOSEF , MARZINZIK ANDREAS , NOZULAK JOACHIM , OFNER SILVIO , ROY BERNARD , SPANKA CARSTEN
Inventor： FLOR PETER JOSEF , MARZINZIK ANDREAS , NOZULAK JOACHIM , OFNER SILVIO , ROY BERNARD , SPANKA CARSTEN
IPC: C07C237/04 , C07C211/29 , C07C217/58 , C07C237/06 , C07C237/22 , C07D209/16 , C07D209/40 , C07D209/42 , C07D209/86 , C07D211/58 , C07D213/38 , C07D213/85 , C07D215/08 , C07D217/04 , C07D217/06 , C07D223/26 , C07D223/28 , C07D233/22 , C07D263/58 , C07D265/38 , C07D307/68 , C07D307/79 , C07D311/68 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/12 , C07D451/14 , C07D495/04
CPC classification number: C07D209/42 , C07C211/29 , C07C217/58 , C07C237/04 , C07C237/06 , C07C237/22 , C07C2601/02 , C07C2602/10 , C07C2603/20 , C07D209/16 , C07D209/86 , C07D211/58 , C07D213/38 , C07D213/85 , C07D215/08 , C07D217/04 , C07D217/06 , C07D223/26 , C07D223/28 , C07D263/58 , C07D265/38 , C07D307/79 , C07D311/68 , C07D401/06 , C07D401/14 , C07D405/12 , C07D495/04
Abstract: The invention relates to novel diamines of the formula (I) in which all variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Abstract translation: 本发明涉及新的式（I）二胺，其中所有变量如说明书中所定义，游离碱形式或酸加成盐形式，它们的制备，它们作为药物的用途和包含它们的药物。
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公开(公告)号：WO2006000420A1
公开(公告)日：2006-01-05
申请号：PCT/EP2005/006815
申请日：2005-06-23
Applicant: NOVARTIS AG , NOVARTIS PHARMA GMBH , IRM LLC , DING, Qiang , GRAY, Nathanael, Schiander , LI, Bing , LIU, Yi , SIM, Taebo , UNO, Tetsuo , ZHANG, Guobao , PISSOT SOLDERMANN, Carole , BREITENSTEIN, Werner , BOLD, Guido , CARAVATTI, Giorgio , FURET, Pascal , GUAGNANO, Vito , LANG, Marc , MANLEY, Paul, W. , SCHOEPFER, Joseph , SPANKA, Carsten
Inventor： DING, Qiang , GRAY, Nathanael, Schiander , LI, Bing , LIU, Yi , SIM, Taebo , UNO, Tetsuo , ZHANG, Guobao , PISSOT SOLDERMANN, Carole , BREITENSTEIN, Werner , BOLD, Guido , CARAVATTI, Giorgio , FURET, Pascal , GUAGNANO, Vito , LANG, Marc , MANLEY, Paul, W. , SCHOEPFER, Joseph , SPANKA, Carsten
IPC: C07D239/48
CPC classification number: C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: The invention relates to compounds of formula (I) wherein the substituents X 1 , R 1 , R 2 , R 3 and R 4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
Abstract translation: 本发明涉及式（I）的化合物，其中取代基X 1，R 1，R 2，R 3， SUP＆gt;和R 4具有本发明的描述中阐述和解释的含义，这些化合物的制备方法，含有它们的药物组合物，其用途可任选地与一种或多种 用于治疗对蛋白激酶活性的抑制作出反应的疾病的更多其它药物活性化合物，以及治疗这种疾病的方法。
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公开(公告)号：WO2010066689A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066550
申请日：2009-12-07
Applicant: NOVARTIS AG , THE SCRIPPS RESEARCH INSTITUTE , IRM LLC , BAUMGARTEN, Birgit , GESSIER, François , KATOPODIS, Andreas , KNOCHENMUSS, Richard , FALCHETTO, Rocco , ROGGO, Silvio , SAILER, Andreas , SEUWEN, Klaus , SPANKA, Carsten , ZHANG, Juan , HANNEDOUCHE, Sébastien , NOËL, Sophie , ROY, Marie-Odile , CHEN, Yu , CHO, Charles Y. , LI, Wei , SHEN, Weijun
Inventor： BAUMGARTEN, Birgit , GESSIER, François , KATOPODIS, Andreas , KNOCHENMUSS, Richard , FALCHETTO, Rocco , ROGGO, Silvio , SAILER, Andreas , SEUWEN, Klaus , SPANKA, Carsten , ZHANG, Juan , HANNEDOUCHE, Sébastien , NOËL, Sophie , ROY, Marie-Odile , CHEN, Yu , CHO, Charles Y. , LI, Wei , SHEN, Weijun
IPC: C07K14/705 , C07K16/28 , C12N15/113 , A61K31/7105 , A61K39/395 , G01N33/566
CPC classification number: C07K14/705 , C12N15/1138 , C12N2310/14 , G01N33/56994 , G01N33/92 , G01N2800/044 , G01N2800/2871 , G01N2800/321
Abstract: The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBI2) and cholest-5-ene-3b,7b,25-triol(7, 25- dihydroxycholesterol)(''7,25DHC'') and/orcholest-5-ene-3b, 7b-diol(7- hydroxycholesterol)(''7HC'') 25-diol (25-hydroxycholesterol)(''25HC''), especially the cholest-5-ene-3b,7a,25-triol(7a, 25-dihydroxycholesterol)(''7a,25DHC'')and/or cholest-5-ene-3b,7b,25-triol(7b, 25-dihydroxycholesterol)(''7b,25DHC'') stereoisomers. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
Abstract translation: 本发明涉及爱泼斯坦 - 巴尔病毒诱导的受体-2（EBI2）和胆甾烯-5-烯-3b，7b，25-三醇（7,25-二羟基胆固醇）（“7,25DHC”）之间相互作用的调节剂 ）和/或胆甾-5-烯-3b，7b-二醇（7-羟基胆固醇）（“7HC”）25-二醇（25-羟基胆固醇）（“25HC”），特别是胆甾-5-烯 - （7a，25-二羟基胆固醇）（“7a，25DHC”）和/或胆甾烯-5-烯-3b，7b，25-三醇（7b，25-二羟基胆固醇）（“7b” ，25DHC“）立体异构体。 调节剂可能是一种小的化学分子，抗体或其他治疗性蛋白质。 还描述了治疗方法和识别调节剂的方法。
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9.发明申请IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE 审中-公开用于治疗C-MET酪氨酸激酶介导疾病的咪唑并[1,2-B]吡啶衍生物
公开(公告)号：WO2009106577A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052302
申请日：2009-02-26
Applicant: NOVARTIS AG , FURET, Pascal , MCCARTHY, Clive , SCHOEPFER, Joseph , SPANKA, Carsten , STANG, Melanie , STAUFFER, Frédéric
Inventor： FURET, Pascal , MCCARTHY, Clive , SCHOEPFER, Joseph , SPANKA, Carsten , STANG, Melanie , STAUFFER, Frédéric
IPC: C07D487/04 , A61K31/5025 , A61P35/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The invention relates to compounds of formula (I) and salts thereof, formula (I) wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharamaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
Abstract translation: 本发明涉及式（I）化合物及其盐，式（I），其中取代基如说明书中所定义，式（I）化合物在治疗人或动物体的方法中的应用 ，特别是关于C-Met酪氨酸激酶介导的疾病; 使用式（I）化合物制备用于治疗这些疾病的药物; 药物组合物，其包含式（I）的化合物，任选地在组合配偶体的存在下; 制备式（I）化合物的方法。
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公开(公告)号：WO2009106539A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052211
申请日：2009-02-25
Applicant: NOVARTIS AG , OAKLEY, Paul , PRESS, Neil John , SPANKA, Carsten , WATSON, Simon James
Inventor： OAKLEY, Paul , PRESS, Neil John , SPANKA, Carsten , WATSON, Simon James
IPC: C07D487/04 , A61K31/519 , A61P37/06
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 2 , X, Y and Z are as defined in the specification.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，X，Y和Z如说明书中所定义。
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