公开(公告)号：WO2005121798A1

公开(公告)日：2005-12-22

申请号：PCT/US2005/019498

申请日：2005-06-03

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  BILLADEAU, Mark, A. ,  DEBAD, Jeff, D. ,  GLEZER, Eli, N. ,  LELAND, Jonathan, K. ,  WIJAYAWARDHANA, Charles, A.

Inventor： BILLADEAU, Mark, A. ,  DEBAD, Jeff, D. ,  GLEZER, Eli, N. ,  LELAND, Jonathan, K. ,  WIJAYAWARDHANA, Charles, A.

IPC: G01N33/543

CPC classification number: G01N33/543 ,  G01N33/523 ,  G01N33/54366 ,  Y10T436/106664 ,  Y10T436/117497 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.

Abstract translation: 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。

公开(公告)号：WO2003023360A2

公开(公告)日：2003-03-20

申请号：PCT/US2002/028652

申请日：2002-09-10

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  GLEZER, Eli, N. ,  JOHNSON, Kent ,  TSIONSKY, Michael ,  KENTEN, John, H. ,  DEBAD, Jeff, D. ,  UMEK, Robert, M. ,  EASON, Paula, Denney ,  BIEBUYCK, Hans ,  WOHLSTADTER, Jacob, N. ,  WILBUR, James ,  SIGAL, George

Inventor： GLEZER, Eli, N. ,  JOHNSON, Kent ,  TSIONSKY, Michael ,  KENTEN, John, H. ,  DEBAD, Jeff, D. ,  UMEK, Robert, M. ,  EASON, Paula, Denney ,  BIEBUYCK, Hans ,  WOHLSTADTER, Jacob, N. ,  WILBUR, James ,  SIGAL, George

IPC: G01N

CPC classification number: G01N33/5304 ,  C12Q1/485 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/54386 ,  G01N33/56944 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/573 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2333/11 ,  G01N2333/135 ,  G01N2333/16 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/545 ,  G01N2333/57 ,  G01N2333/71 ,  G01N2333/9121 ,  Y10S436/807

Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract translation: 使用具有多个测定域的测定模块进行多重测试测量。 在优选的实施方案中，这些测量在具有集成电极的测定模块中进行，所述测定模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。 p>

公开(公告)号：WO2016164477A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026242

申请日：2016-04-06

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  GLEZER, Eli, N. ,  EDENS, Carl ,  JEFFREY-COKER, Bandele ,  KOVACS, Sandor ,  FRYE, Christopher

Inventor： GLEZER, Eli, N. ,  EDENS, Carl ,  JEFFREY-COKER, Bandele ,  KOVACS, Sandor ,  FRYE, Christopher

IPC: B01F11/00 ,  B01L3/00 ,  B06B1/16 ,  G05D11/04

CPC classification number: G01N35/00029 ,  B01F11/0014 ,  B01F2215/0037 ,  B06B1/16 ,  B06B1/167 ,  G01N33/54366 ,  G01N35/00732 ,  G01N35/0099 ,  G01N35/10 ,  G01N2035/00148

Abstract: The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

Abstract translation: 本发明涉及用于在固相上进行测定以测量样品中分析物水平的系统。 这样的系统可以使用电化学发光（ECL）进行免疫测定，其包括用于测定消耗品的平衡轨道振荡装置。

公开(公告)号：WO2014107576A2

公开(公告)日：2014-07-10

申请号：PCT/US2014/010182

申请日：2014-01-03

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  CHAMBERLIN, Ian ,  CLINTON, Charles, M. ,  GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  KOCHAR, Manish ,  KOVACS, Sandor ,  LE, D.T. ,  LEIMKUEHLER, Aaron ,  SIGAL, George ,  TABAKIN, Leo ,  WILLOUGHBY, Jon

Inventor： CHAMBERLIN, Ian ,  CLINTON, Charles, M. ,  GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  KOCHAR, Manish ,  KOVACS, Sandor ,  LE, D.T. ,  LEIMKUEHLER, Aaron ,  SIGAL, George ,  TABAKIN, Leo ,  WILLOUGHBY, Jon

IPC: G02B7/36 ,  G01J1/20 ,  G01N27/26

CPC classification number: G02B7/36 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/028

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

Abstract translation: 描述了用于进行测定的装置，系统，方法，试剂和试剂盒及其制备方法。 它们特别适用于以多孔板测定方式进行自动化分析。

公开(公告)号：WO2007076023A3

公开(公告)日：2007-07-05

申请号：PCT/US2006/049048

申请日：2006-12-21

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  DEBAD, Jeff, D. ,  KUMAR, Sudeep, M. ,  SIGAL, George ,  SPIELES, Gisbert ,  TSIONKSY, Michael ,  WARNOCK, Michael

Inventor： GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  DEBAD, Jeff, D. ,  KUMAR, Sudeep, M. ,  SIGAL, George ,  SPIELES, Gisbert ,  TSIONKSY, Michael ,  WARNOCK, Michael

IPC: G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：WO2014160192A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/026010

申请日：2014-03-13

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： AGHVANYAN, Anahit ,  GLEZER, Eli, N. ,  KENTEN, John ,  SIGAL, George ,  STENGELIN, Martin

IPC: G01N33/53 ,  G01N33/532 ,  G01N33/58

CPC classification number: G01N33/54393 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/56988 ,  G01N33/582 ,  G01N2021/7786 ,  C12Q2537/125 ,  C12Q2563/179

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

Abstract translation: 本发明涉及用于改善结合测定中测定特异性和性能的方法。

公开(公告)号：WO2014008381A3

公开(公告)日：2014-01-09

申请号：PCT/US2013/049296

申请日：2013-07-03

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  PAGE, Kenneth ,  KOVACS, Sandor ,  KUMAR, Sudeep ,  ROTH, Kristian

Inventor： GLEZER, Eli, N. ,  JEFFREY-COKER, Bandele ,  PAGE, Kenneth ,  KOVACS, Sandor ,  KUMAR, Sudeep ,  ROTH, Kristian

IPC: F16K11/06

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed. The multi-port valve has a cap, a stator comprising a rotor engagement member, and a rotor biased toward the stator and comprising a sealing member disposed between the rotor and the stator. A stator engagement member is configured to disengage the rotor when the stator engagement member is in communication with the rotor engagement member.

公开(公告)号：WO2011071772A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/058913

申请日：2010-12-03

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  ANDERSON, Nicholas ,  DEBAD, Jeffrey ,  GLEZER, Eli, N. ,  KUMAR, Sudeep ,  LAWRENCE, Noel ,  PAGE, Kenneth ,  SIGAL, George ,  WEST, Sharon

Inventor： ANDERSON, Nicholas ,  DEBAD, Jeffrey ,  GLEZER, Eli, N. ,  KUMAR, Sudeep ,  LAWRENCE, Noel ,  PAGE, Kenneth ,  SIGAL, George ,  WEST, Sharon

IPC: G01N21/03

CPC classification number: G01N21/05 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L7/00 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/024 ,  B01L2300/027 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/0672 ,  B01L2400/0683 ,  B01L2400/0688 ,  G01F23/02 ,  G01F23/292 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/69 ,  G01N21/76 ,  G01N2021/0346 ,  Y10T137/0396 ,  Y10T137/8593

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

Abstract translation: 描述了具有检测室，优选具有集成电极的测定盒，以及可包括样品室，废物室，导管，通气口，气泡阱，试剂室，干试剂药片区等的其它流体组分。 在某些实施例中，这些盒适于接收和分析在施用器棒上收集的样品。 还描述了包括这种盒的试剂盒和盒读取器，其被配置为分析使用分析盒进行的分析。

公开(公告)号：WO2009126303A2

公开(公告)日：2009-10-15

申请号：PCT/US2009/002244

申请日：2009-04-10

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  CLINTON, Charles, M. ,  GLEZER, Eli, N. ,  WEST, Sharon ,  SIGAL, George ,  STEVENS, Carl ,  VOCK, Michael

Inventor： CLINTON, Charles, M. ,  GLEZER, Eli, N. ,  WEST, Sharon ,  SIGAL, George ,  STEVENS, Carl ,  VOCK, Michael

IPC: G01N1/28 ,  G01N35/00 ,  G01N21/00

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N35/1079 ,  G01N2035/0425 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

Abstract translation: 我们描述了用于进行测定的装置，系统，方法，试剂和试剂盒以及它们的制备方法。 它们特别适合于以多孔板分析方式进行自动取样，样品制备和分析。 例如，它们可以用于自动分析空气中的微粒和/或从环境监测中得到的液体样品。

公开(公告)号：WO2010127057A3

公开(公告)日：2010-11-04

申请号：PCT/US2010/032879

申请日：2010-04-29

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  GLEZER, Eli, N. ,  MATHEW, Anu

Inventor： GLEZER, Eli, N. ,  MATHEW, Anu

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/15

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.