Abstract:
The present invention relates to an extracorporeal circuit (300, 400) for the treatment of hydroelectrolyte and acid-base blood imbalances comprising a blood withdrawal line (2) from the patient, a first filter unit (6) and a blood reinsertion line (5) in the patient defining a main circuit (12). The extracorporeal circuit (1, 100, 200, 300, 400) further comprises an electrolytic restoration group (4) suitable for providing a chlorine-poor solution (30b) and means (16) for the infusion of the chlorine-poor solution (30b) on the main circuit (12). The electrolytic restoration group (4) comprises an electrodialyzer (10) comprising a first electrodialysis chamber (21) and a second electrodialysis chamber (22), separated by an anionic membrane (23), and separated from the respective electrode (24,25) by means of a bipolar membrane (26, 27).
Abstract:
The present invention relates to systems, methods and uses for recycling at least a part of water lost during various renal replacement therapy processes, e.g. in the preparation of a fresh dialysate solution or fresh reconstitution fluid for kidney disease dialysis and hemofiltration by utilizing water from the spent fluids. The system of the invention is useful in hemodialysis and in peritoneal dialysis as well as in hemofiltration for reuse of water from filtrates and spent fluids. In addition, the system of the invention is useful in the development of a renal assist device or artificial kidney.
Abstract:
A device for the elimination of carbon dioxide from the blood, provided with an inlet (98) for pressurized oxygen, an inlet (90) for the blood to be treated, an outlet (50) for the treated blood and an outlet (94) for the carbon dioxide to be eliminated, said device (59) comprising a decapneisator or oxygenating device (9) and a haemo-concentrator (5) having an outlet section (51) for the ultrafiltrate, said outlet section (51) being connected upstream of the decapneisator (9), so as to pre-dilute the blood entering said inlet (90).
Abstract:
Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability.
Abstract:
A machine for conducting dialsis of body fluids of a patient is disclosed. The machine (22) includes integral water preparation and treatment (24), dialysate preparation (26), and extracorporeal circuit modules (28), under computer control from a patient interface and control module (25). A water pretreatment module (20) with a temperature-controlled mixing valve (36), an integral water filtration and conditioning unit (40) and a pressure relief valve (38) with integral water sample removal port (78) supplies water to the machine (22). Methods off disinfecting and cleaning dialysis machine (22), a method of conducting dialysis, a method of automatically testing the integrity of a dialysate filter and/or a dialyzer, and a method of approximating the sodium clearance of a dialyzer are also disclosed.
Abstract:
Artificial kidney for gradual, and at least semi-continuous, blood treatment, wherein a blood stream is fed from a body of a living human or animal being into the artificial kidney, where anticoagulation is first effected, blood cells and molecules of large and medium molecular weight, such as proteins, are then primarily separated from plasma and fed back to the blood stream, regulating a water and salt balance by diverting excess plasma water and further removing from the blood stream, plasma or plasma water accumulated and toxic substances, by removal of specific electrolytes and waste products and wherein purified or partially purified plasma and plasma water is being carried back to the blood tract of the body.
Abstract:
A method of treating a patient with cardiorenal syndrome and hepatorenal syndrome are provided in which a portion of the body fluid of the patient is exposed to renal epithelial cells, outside of the kidney of the patient, whereby the body fluid is in fluid communication with renal epithelial cells and is modified by renal epithelial cells.
Abstract:
A system comprising a blood circuit including a membrane arranged in a blood filter (7) in which blood is in contact with a first side of said membrane; and a dialysis circuit in which a dialysis fluid is in contact with the other side of the membrane for exchange of substances and ions through the membrane as well as water. The dialysis fluid is circulated from a dialysis compartment and through a RO filter (9) . The permeate fluid, i.e. water is returned to the dialysis compartment. The retentate fluid from the RO filter (9) passes through a separation filter (13) . The retentate fluid is returned to the dialysis compartment and the permeate fluid is removed from the dialysis circuit as a waste fluid to a receptacle (19) . The retentate fluid is concentrated in the RO filter in a ration of at least 3:1.
Abstract:
Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability.
Abstract:
The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter (102) to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid (150) into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.