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    Analytical cartridge and system for detecting analytes in liquid samples
    2.
    发明授权
    Analytical cartridge and system for detecting analytes in liquid samples 失效
    用于检测液体样品中分析物的分析盒和系统

    公开(公告)号：US5223219A

    公开(公告)日：1993-06-29

    申请号：US867162

    申请日：1992-04-10

    申请人： Kumar Subramanian ,  Jeffrey Sugarman ,  Bernhard B. Sterling ,  Fred Voss ,  Marina Saltman

    发明人： Kumar Subramanian ,  Jeffrey Sugarman ,  Bernhard B. Sterling ,  Fred Voss ,  Marina Saltman

    IPC分类号： B01L3/00 ,  G01N21/03 ,  G01N21/78 ,  G01N33/66 ,  G01N33/72 ,  G01N33/92

    CPC分类号： G01N21/03 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/082 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L3/5023 ,  B01L3/502746 ,  G01N2021/0346 ,  G01N2021/035 ,  G01N21/474 ,  Y10S366/01

    摘要： A diagnosis system, which comprises a monitor, comprising a detector providing multiple reflectance readings in an array of individual locations, registering an analytical cartridge in the monitor at a fixed location and orientation relative to the array, and determines and displays analytical results from reflectance readings; and an analytical cartridge, comprising a liquid impervious housing, a sample application site in the housing located outside the monitor when the cartridge is registered in the monitor by the means for registering, one or more reflectance reading sites in the housing that register with one or more of the locations in the array, a capillary pathway in the housing leading from the sample application site to each of the reflectance reading sites, and a reflectance matrix located in at least one of the reflectance reading sites. In some embodiments of the invention, control features that optimize accuracy of measurement by controlling when and if sample reaches reflectance reading sites and by drawing excess sample away from undesirable locations in the cartridge are present. One control element balances the liquid-holding capacities of the application site, the sample-transporting capillary passageway that leads to the reflectance reading site, and the porous matrices from which the reflectance reading will be made, so that excess sample is excluded from entry into the cartridge while sample volumes that are below the minimum necessary for accurate operation do not reach the matrix, thereby avoiding false readings.

    摘要翻译： 一种诊断系统，其包括监视器，其包括检测器，其在各个位置的阵列中提供多个反射读数，以相对于阵列的固定位置和取向将分析盒注册在监视器中，并且确定并显示来自反射读数的分析结果 ; 以及分析盒，包括不透液体的壳体，当所述盒通过所述记录装置登记在所述监视器中时，位于所述显示器外部的壳体中的样品施加位置，所述壳体中的一个或多个反射率读数位置与一个或多个 阵列中更多的位置，从样品应用位点引导到每个反射率读取位置的壳体中的毛细管路径，以及位于至少一个反射读取位置的反射矩阵。 在本发明的一些实施例中，存在通过控制样品到达反射率读取位置以及通过将多余的样品远离盒中不期望的位置的时间和时间来优化测量精度的控制特征。 一个控制元件平衡施加部位的液体保持能力，导致反射率读取位置的样品输送毛细管通道和将从其进行反射率读数的多孔基质，使得过量样品被排除进入 当低于准确操作所需最小值的样品体积未达到基质时，墨盒的墨盒不会被误读。

    Integrated serial dilution and mixing cartridge
    3.
    发明授权
    Integrated serial dilution and mixing cartridge 失效
    集成串联稀释和混合筒

    公开(公告)号：US5077017A

    公开(公告)日：1991-12-31

    申请号：US117791

    申请日：1987-11-05

    申请人： Michael M. Gorin ,  Robert S. Hillman ,  Ian Gibbons ,  Michael E. Cobb

    发明人： Michael M. Gorin ,  Robert S. Hillman ,  Ian Gibbons ,  Michael E. Cobb

    IPC分类号： B01F13/08 ,  B01F15/04 ,  G01N1/38 ,  G01N33/04

    CPC分类号： G01N1/38 ,  B01F13/0818 ,  B01F15/04 ,  G01N33/04 ,  Y10T436/25625

    摘要： A dilution and mixing cartridge comprising a sample application site, a mixing chamber in fluid receiving relationship to the sample application site, a diluent application site in fluid donating relationship to the mixing chamber, a first valve means selectively preventing flow from the diluent application site to the mixing chamber, and a mixture isolating chamber hydrostatically connected to the mixing chamber is provided along with a method for using this cartridge to sequentially dilute a sample with the same or different diluents.

    摘要翻译： 一种稀释和混合筒，包括样品施加部位，与样品施加部位处于流体接收关系的混合室，与混合室具有流体供给关系的稀释剂施加部位，选择性地防止从稀释剂施用部位流向 混合室以及静态连接到混合室的混合物隔离室以及使用该滤筒依次稀释具有相同或不同稀释剂的样品的方法。

    Apparatus and method for dilution and mixing of liquid samples
    9.
    发明授权
    Apparatus and method for dilution and mixing of liquid samples 失效
    液体样品稀释和混合的装置和方法

    公开(公告)号：US4946795A

    公开(公告)日：1990-08-07

    申请号：US395808

    申请日：1989-08-18

    申请人： Ian Gibbons ,  Robert S. Hillman ,  Channing R. Robertson ,  Jimmy D. Allen

    发明人： Ian Gibbons ,  Robert S. Hillman ,  Channing R. Robertson ,  Jimmy D. Allen

    IPC分类号： B01F13/00 ,  B01F13/08 ,  B01F15/04 ,  G01N1/38 ,  G01N33/04

    CPC分类号： B01F13/0059 ,  B01F13/0818 ,  B01F15/04 ,  G01N1/38 ,  G01N33/04 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.

    摘要翻译： 一种用稀释剂稀释样品的装置，包括固定容积测量室，固定容积接收室和与测量室的流体接收关系，接收室中的气体通道，测量室和接收器之间的停止流动接合 室，与测量室的流体供应关系的样品施加部位，其中样品施加部位和止动流动接合点之间的垂直高度差不足以提供当施加样品时能够克服止动流动接合处的背压的静水压力 到样品应用场所，以及稀释剂施用部位和与测量室的流体供给关系。 样品和稀释剂依次添加到本发明的装置中，而不需要任何中间操作。 提供了重新启动流动的各种装置，这使得稀释剂将样品洗涤到接收室中，其中两个可以混合。

    Capillary mixing device
    10.
    发明授权
    Capillary mixing device 失效
    毛细管混合装置

    公开(公告)号：US5222808A

    公开(公告)日：1993-06-29

    申请号：US867155

    申请日：1992-04-10

    申请人： Jeffrey Sugarman ,  Ian Gibbons

    发明人： Jeffrey Sugarman ,  Ian Gibbons

    IPC分类号： B01F13/00 ,  B01F13/08

    CPC分类号： B01F13/0059 ,  B01F13/0809 ,  B01F15/0232 ,  B01F2215/0037

    摘要： A capillary mixing device, comprising a liquid impervious housing; an interior space in the housing comprising a chamber in the housing having capillary spacing in one dimension and non-capillary spacing in other dimensions; and a plurality of magnetic or magnetically inducible particles in the chamber. The chamber is normally accessed through one or more capillary passageways leading to a surface of the housing and is adapted to be retained by a magnetic device that comprises means for generating a moving magnetic field and means for retaining the chamber device in an orientation so that the magnetic field has a field vector that intersects the capillary chamber perpendicular to the dimension having capillary spacing.

    摘要翻译： 一种毛细管混合装置，包括不透液体的壳体; 壳体中的内部空间包括壳体中的腔室，其中一个维度具有毛细管间隔，在其它尺寸上具有非毛细管间隔; 以及腔室中的多个磁性或磁性诱导性颗粒。 通常通过通过一个或多个毛细管通道进入腔室，该毛细通道通向外壳的表面，并且适于由包括用于产生移动磁场的装置的磁性装置保持，以及用于将腔室装置保持在定向中的装置， 磁场具有与垂直于具有毛细管间隔的尺寸的毛细管腔相交的场向量。