-
公开(公告)号：US20240309304A1
公开(公告)日：2024-09-19
申请号：US18598039
申请日：2024-03-07
发明人： Yong Yang , Jiafeng Liu , Kun Man
CPC分类号： C12M23/16 , C12M23/26 , C12M23/58 , C12M25/02 , C12M35/04 , C12M41/46 , C12N5/0656 , C12N5/0688 , C12N2533/90 , C12N2539/00
摘要： Provided herein is a 3D microfluidic device mimicking an anatomy and physiology of a human lung alveolar interstitium comprising: at least one inlet and one outlet in fluid communication with an inlet chamber and an outlet chamber; an interstitium chamber that comprises an electrospun nanofibrous membrane to support the growth of lung epithelial cells and fibroblasts, at least one inlet chamber and an outlet chamber to provide a growth media to the lung epithelial cells and fibroblasts; a pneumatic chamber separated from the interstitium chamber by a water-impermeable membrane and a source of air in fluid communication with the pneumatic chamber; and an air chamber in fluid communication a second side of the with electrospun nanofibrous membrane of the interstitium chamber, wherein the air chamber is opposite the pneumatic chamber; wherein the integration of inputs and outputs mimics the anatomy and physiology of the human lung alveolar interstitium.
-
公开(公告)号：US20240304277A1
公开(公告)日：2024-09-12
申请号：US18263906
申请日：2022-03-14
发明人： Jianye Ge , Bruce Budowle , Jonathan King , Amy Smuts
IPC分类号： G16B20/00 , C12Q1/6851
CPC分类号： G16B20/00 , C12Q1/6851
摘要： The present invention includes methods and kits for determining one or more nucleic acid contributors to a sample or specimen from single cells in a sample, comprising: counting isolated cells and cell types; determining a mixture ratio of isolated cells and cell types; generating amplicons from each cell in the sample; calculating from the counted isolated cells, the cell types, the mixture ratio and amplicons from each single cell; comparing the amplicons a reference or known amplicon profile from a subject suspected of contributing nucleic acids; clustering the cells to contributors; identifying a number of contributors to the biological sample or specimen; generating consensus profiles for each contributor, and comparing the consensus profde of each contributor to a reference or known amplicon profde from a subject suspected of contributing nucleic acids to the biological sample or specimen.
-
3.发明公开公开(公告)号：US20240226035A1
公开(公告)日：2024-07-11
申请号：US18559087
申请日：2022-05-04
发明人： O'Bryant Sid E.
IPC分类号： A61K31/137 , A61K31/015 , A61K31/07 , A61K31/095 , A61K31/122 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/194 , A61K31/352 , A61K31/375 , A61K31/4045 , A61K31/42 , A61K31/421 , A61K31/4985 , A61K31/50 , A61K31/5375 , A61K33/00 , A61K33/04 , A61K38/06 , G16B25/10 , G16B40/20
CPC分类号： A61K31/137 , A61K31/015 , A61K31/07 , A61K31/095 , A61K31/122 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/194 , A61K31/352 , A61K31/375 , A61K31/4045 , A61K31/42 , A61K31/421 , A61K31/4985 , A61K31/50 , A61K31/5375 , A61K33/00 , A61K33/04 , A61K38/063 , G16B25/10 , G16B40/20
摘要： The present invention includes a method for selecting a subject for a targeted treatment for Parkinson's Disease, the method comprising: obtaining or having obtained a sample from the subject; measuring in the blood or serum sample the expression level of one or more first biomarkers; comparing the level of expression of the one or more first biomarkers from the subject's sample with the expression level of a corresponding one or more first biomarkers from a statistical sample representative of biomarkers in a normal subject; and if the subject is found to have a statistically different expression level of the one or more biomarkers when compared to the expression level of the corresponding one or more biomarkers from the statistical sample, treating the subject with a monoamine oxidase inhibitor, an antioxidant, or both.
-
公开(公告)号：US12023710B2
公开(公告)日：2024-07-02
申请号：US17343466
申请日：2021-06-09
IPC分类号： B05D3/06 , B05D3/14 , B05D7/14 , C08F220/24 , C09D5/08 , C09D133/16 , C09D171/02 , C22C21/00 , C23F1/36
CPC分类号： B05D3/067 , B05D3/142 , B05D7/14 , C08F220/24 , C09D5/082 , C09D133/16 , C09D171/02 , C22C21/00 , C23F1/36 , B05D2202/25 , B05D2502/00 , C08F220/24 , C08F222/1063
摘要： The hydrophobic and corrosion resistive film of cross-linked poly(hexafluoroisopropyl methacrylate) was prepared by photopolymerization. The starting materials were a monomer of 1,1,1,3,3,3-hexafluoroisopropyl methacrylate, a photoinitiator of hydroxycyclohexyl phenyl ketone, and a cross-linker of poly(ethyleneglycol diacrylate). Photopolymerization was used to start polymerization and to cure the polymer film on an aluminum surface. Drop-casting was used to deposit the fluoropolymer onto an aluminum substrate (AA 3003). The fluoropolymer film has high corrosion protection when measured by potentiodynamic polarization and open circuit potential techniques in an aqueous solution of 3.5% NaCl. Fourier-transform infrared spectroscopy was used to monitor the polymerization process. The dynamic contact angle technique was used to measure the hydrophobicity for the fluorinated polymer coating. Thermal stability of the fluorinated polymer was measured using thermogravimetric analysis. Treatment with strong acid followed by contact angle measurements before and after the treatment confirmed the chemical resistance for the coated aluminum.
-
公开(公告)号：US20240153306A1
公开(公告)日：2024-05-09
申请号：US18485285
申请日：2023-10-11
CPC分类号： G06V40/171 , G06V10/54 , G06V10/82 , G06V20/46 , G06V40/161 , G06V40/45
摘要： A method of identifying synthetic media can include identifying a facial image in video or images, extracting a first set of features from the facial image, extracting a second set of features from the facial image, wherein the first set of features are different than the second set of features, inputting the first set of features into a first prediction model, generating a first output indicative of a nature of the facial image, inputting the second set of features into a second prediction model, generating a second output indicative of the nature of the facial image, and determining the nature of the facial image using the first output and the second output.
-
公开(公告)号：US20240142473A1
公开(公告)日：2024-05-02
申请号：US18548840
申请日：2022-03-04
发明人： Sid E. O'BRYANT
IPC分类号： G01N33/68 , C12Q1/6876
CPC分类号： G01N33/6896 , C12Q1/6876 , C12Q2600/158 , G01N2800/52 , G01N2800/60
摘要： The present disclosure relates to a method of treating a subject having a proinflammatory endophenotype profile with celecoxib or naproxen to improve cognition or to prevent cognitive decline or dysfunction in the subject. In another aspect, the present disclosure relates to a method of screening a subject for inclusion an NSAID or a PPAR-7 agonist clinical trial. In another aspect, the present disclosure relates to a method of determining a surrogate outcome of an NSAID or a PPAR-7 agonist clinical trial. In yet another aspect, the present disclosure relates to a method of treating an Alzheimer's disease patient having both a proinflammatory endophenotype profile and a metabolic endophenotype profile with a PPAR-7 agonist to improve cognition or to prevent cognitive decline or dysfunction in the patient.
-
公开(公告)号：US20240124826A1
公开(公告)日：2024-04-18
申请号：US18486887
申请日：2023-10-13
发明人： Yong YANG , Michelle Leyi YANG , Catalina ZUO , Zhenyu ZUO
摘要： An electromagnetically driven one-dimensional stretching device includes a stretchable surface, and an electromagnetic actuator coupled to the stretchable surface. The electromagnetic actuator is configured to stretch the stretchable surface along one-dimension. A method can include spin-coating a weight ratio of about 10:1 about 1:1 of a polydimethylsiloxane resin to a curing agent mixture on a surface to form a stretchable surface, removing the stretchable surface from the surface, coupling an electromagnetic actuator to the stretchable surface, and stretching the stretchable surface along one-dimension using the electromagnetic actuator.
-
公开(公告)号：US11885816B2
公开(公告)日：2024-01-30
申请号：US15037492
申请日：2014-11-26
发明人： Sid E. O'Bryant
CPC分类号： G01N33/6896 , C12Q1/6883 , G16B40/00 , G16B40/20 , G16B40/30 , G16H50/20 , G16H50/30 , C12Q2600/106 , C12Q2600/158 , G01N2800/2814 , G01N2800/52 , G01N2800/60 , G01N2800/7095
摘要： The present invention includes methods for selecting a therapy for improved cognition as well as prevention of cognitive loss/dysfunction using one or more endophenotypes comprising: obtaining a sample from a subject; measuring biomarkers that differentiate between an inflammatory, a metabolic, a neurotrophic, and a depressive endophenotype; and selecting a course of treatment for the subject based on whether the subject is scored as having a high or a low endophenotype for one or more of the inflammatory, a metabolic, a neurotrophic, and a depressive endophenotypes.
-
公开(公告)号：US20240026528A1
公开(公告)日：2024-01-25
申请号：US18357114
申请日：2023-07-22
发明人： Diana BERMAN , Elena V. SHEVCHENKO , Supratik GUHA
CPC分类号： C23C16/045 , C23C16/06 , C23C16/01
摘要： A method of forming an inorganic film on a surface can include depositing a polymer at a layer on a surface, swelling the polymer with a solvent to produce a swollen polymer on the surface, infiltrating the swollen polymer with a precursor, removing the swollen polymer after infiltrating the swollen polymer with the precursor, and forming a porous inorganic film on the surface based on removing the swollen polymer.
-
公开(公告)号：US20240016828A1
公开(公告)日：2024-01-18
申请号：US18454671
申请日：2023-08-23
发明人： Yu-Chieh WANG , Victor J.T. LIN , Ashwini Ashwini ZOLEKAR , Kyle A. EMMITTE , Nigam M. MISHRA , Jin LIU
IPC分类号： A61K31/7105 , A61P35/00 , C07D309/14 , C12N15/113
CPC分类号： A61K31/7105 , A61P35/00 , C07D309/14 , C12N15/1137 , A61K45/06
摘要： In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula:
wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.
-
-
-
-
-
-
-
-
-
搜索结果
363 条记录 (耗时 0.054 秒)
