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公开(公告)号：US11667662B2
公开(公告)日：2023-06-06
申请号：US17206896
申请日：2021-03-19
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ui Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
CPC分类号： C07H19/23 , A61K31/70 , A61K31/706 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07F9/65616 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7076 , A61K2300/00 , A61K31/7064 , A61K2300/00 , A61K31/706 , A61K2300/00
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20210269422A1
公开(公告)日：2021-09-02
申请号：US17260847
申请日：2019-07-17
IPC分类号： C07D401/14 , A61K45/06 , C07K16/28
摘要： The present invention provides solid forms, solvates and hydrates of 3-[2-amino-6-(1-{[6-(2-hydroxypropan-2-yl)pyridine-2-yl]methyl}-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl]-2-methylbenzonitrile, and methods of making and using the same.
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公开(公告)号：US20240352057A1
公开(公告)日：2024-10-24
申请号：US18516459
申请日：2023-11-21
发明人： Laurent Pierre Paul DEBIEN , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ui Sharif
IPC分类号： C07H19/23 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207
CPC分类号： C07H19/23 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07F9/65616 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US12103907B2
公开(公告)日：2024-10-01
申请号：US18239892
申请日：2023-08-30
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US12064433B2
公开(公告)日：2024-08-20
申请号：US17263016
申请日：2019-07-26
发明人： Manmohan Reddy Leleti , Debashis Mandal , Dillon Harding Miles , Jay Patrick Powers , Brandon Reid Rosen , Ehesan U I Sharif
IPC分类号： A61K33/243 , A61K31/282 , A61K31/517 , A61K31/519 , A61K31/704 , A61K45/06 , C07D401/14 , C07D405/14
CPC分类号： A61K31/517 , A61K31/282 , A61K31/519 , A61K31/704 , A61K33/243 , A61K45/06 , C07D401/14 , C07D405/14
摘要： Compound that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US11407712B2
公开(公告)日：2022-08-09
申请号：US17205273
申请日：2021-03-18
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US10981944B2
公开(公告)日：2021-04-20
申请号：US16273843
申请日：2019-02-12
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11993584B2
公开(公告)日：2024-05-28
申请号：US17260847
申请日：2019-07-17
IPC分类号： C07D401/14 , A61K45/06 , C07K16/28
CPC分类号： C07D401/14 , A61K45/06 , C07K16/2818 , C07K16/2827 , C07B2200/13
摘要： The present invention provides solid forms, solvates and hydrates of 3-[2-amino-6-(1-{[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl}-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl]-2-methylbenzonitrile (Compound I),
and methods of making and using the same.-
公开(公告)号：US20240124490A1
公开(公告)日：2024-04-18
申请号：US18219046
申请日：2023-07-06
发明人： Joshua R. Corbin , Sandeep Dhanju , Corinne Nicole Foley , Jeremy Fournier , Padmanabha V. Kattamuri , Manmohan Reddy Leleti , Pradeep Nareddy , Jay Patrick Powers , Ehesan Ul Sharif , Joice Thomas
IPC分类号： C07D519/00 , C07D513/04
CPC分类号： C07D519/00 , C07D513/04
摘要： Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
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公开(公告)号：US11058704B2
公开(公告)日：2021-07-13
申请号：US16338975
申请日：2017-10-02
发明人： Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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