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    Layered aligned polymer structures and methods of making same
    3.
    发明申请
    Layered aligned polymer structures and methods of making same 审中-公开
    分层对准的聚合物结构及其制备方法

    公开(公告)号：US20050019488A1

    公开(公告)日：2005-01-27

    申请号：US10611674

    申请日：2003-06-30

    申请人： Gavin Braithwaite ,  Jeffrey Ruberti

    发明人： Gavin Braithwaite ,  Jeffrey Ruberti

    IPC分类号： A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  B29C41/04 ,  B29C41/22 ,  B29C41/36 ,  B29C41/52 ,  B29C47/00 ,  B29C67/00 ,  B29C67/24 ,  C08L89/06 ,  D01D5/38 ,  D01F4/00 ,  B05D3/00

    CPC分类号： A61L27/3813 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3843 ,  A61L27/50 ,  A61L2400/18 ,  B29C41/045 ,  B29C41/22 ,  B29C41/36 ,  B29C41/52 ,  B29C48/022 ,  B29C48/05 ,  B29C67/0003 ,  B29C67/24 ,  B29C2037/90 ,  B29K2089/00 ,  B29K2995/005 ,  C08L89/06 ,  D01D5/18 ,  D01D5/38 ,  D01F4/00

    摘要： This invention includes a method of producing a nanostructured artificial template comprising more than one thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells.

    摘要翻译： 本发明包括一种制备纳米结构人造模板的方法，其包含多于一个薄的取向层的聚合物材料。 该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液中的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。 用于形成材料的定向层的系统提供在材料沉积物上或其上的输送系统和基底之间的相对运动。 控制来自输送系统的材料的流动速率以及在将其输送到表面时沉积表面和材料之间的相对速度被控制以使材料适当地定向在期望的厚度。 可以调整这些速率以便以受控的方式改变胶片的性质。 优选实施例包括在输送系统和基底之间的角度或线性的相对运动。 纳米结构人造模板可用于诱导由细胞群产生模板的细胞外基质。

    SYSTEMS AND METHODS FOR CONTROLLING AND FORMING POLYMER GELS
    5.
    发明申请
    SYSTEMS AND METHODS FOR CONTROLLING AND FORMING POLYMER GELS 有权
    用于控制和形成聚合物凝胶的系统和方法

    公开(公告)号：US20060270781A1

    公开(公告)日：2006-11-30

    申请号：US11462799

    申请日：2006-08-07

    申请人： Jeffrey Ruberti ,  Gavin Braithwaite

    发明人： Jeffrey Ruberti ,  Gavin Braithwaite

    IPC分类号： A61F2/44 ,  C08L29/04

    CPC分类号： A61F2/442 ,  A61F2002/444 ,  A61L27/16 ,  A61L27/52 ,  A61L2430/38 ,  C08J3/09 ,  C08J2329/04 ,  C08L29/04 ,  Y10S516/902 ,  Y10S524/916 ,  C08L2666/26

    摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gellation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

    摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供了通过可控制的粘弹性溶液凝胶制备的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

    Systems and methods for controlling and forming polymer gels
    7.
    发明申请
    Systems and methods for controlling and forming polymer gels 审中-公开
    用于控制和形成聚合物凝胶的系统和方法

    公开(公告)号：US20070167541A1

    公开(公告)日：2007-07-19

    申请号：US10566263

    申请日：2004-02-04

    申请人： Jeffrey Ruberti ,  Gavin Braithwaite

    发明人： Jeffrey Ruberti ,  Gavin Braithwaite

    IPC分类号： C08K5/15

    CPC分类号： C08J3/09 ,  A61K9/0024 ,  C08J2329/04

    摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution: inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution wherein workability is maintained for a predetermined period thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

    摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝胶混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数：引起凝胶化 乙烯基聚合物溶液和胶凝剂的混合物; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

    Layered aligned polymer structures and methods of making same
    8.
    发明申请
    Layered aligned polymer structures and methods of making same 审中-公开
    分层对准的聚合物结构及其制备方法

    公开(公告)号：US20060159722A1

    公开(公告)日：2006-07-20

    申请号：US10536409

    申请日：2003-11-26

    申请人： Gavin Braithwaite ,  Jeffrey Ruberti

    发明人： Gavin Braithwaite ,  Jeffrey Ruberti

    IPC分类号： C12N5/08 ,  A61K9/70 ,  A61K35/44

    CPC分类号： A61L27/3813 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3843 ,  A61L27/50 ,  A61L2400/18 ,  B29C41/045 ,  B29C41/22 ,  B29C41/36 ,  B29C41/52 ,  B29C48/022 ,  B29C48/05 ,  B29C67/0003 ,  B29C67/24 ,  B29C2037/90 ,  B29K2089/00 ,  B29K2995/005 ,  C08L89/06 ,  D01D5/18 ,  D01D5/38 ,  D01F4/00

    摘要： This invention includes a method of producing a nanostructured artificial template comprising one or more thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow in a predominantly monomeric solution of the self-assembling polymer sub-units to the free surface of a substrate and inducing polymerization or growth of the monomer while in this shearing flow. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells. The invention further includes a method of remodeling collagen constructs by alternating application of proteases and collagen monomers while the construct is stressed.

    摘要翻译： 本发明包括一种制备纳米结构人造模板的方法，其包括一个或多个薄的取向层的聚合物材料。 该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液到基材的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。 控制来自输送系统的材料的流动速率以及在将其输送到表面时沉积表面和材料之间的相对速度被控制以使材料适当地定向在期望的厚度。 可以调整这些速率以便以受控的方式改变胶片的性质。 纳米结构人造模板可用于诱导由细胞群产生模板的细胞外基质。 本发明还包括通过交替施用蛋白酶和胶原单体来改造胶原构建体的方法，同时构造物被应激。

    GASTRIC VOLUME FILLING CONSTRUCT
    9.
    发明申请
    GASTRIC VOLUME FILLING CONSTRUCT 审中-公开
    气体填充结构

    公开(公告)号：US20110295299A1

    公开(公告)日：2011-12-01

    申请号：US13039067

    申请日：2011-03-02

    申请人： Gavin Braithwaite ,  Martin van Buren ,  Stephen Spiegelberg ,  Shantanu Gaur ,  Samuel Levy ,  Jonathan Wecker ,  Ram Chuttani

    发明人： Gavin Braithwaite ,  Martin van Buren ,  Stephen Spiegelberg ,  Shantanu Gaur ,  Samuel Levy ,  Jonathan Wecker ,  Ram Chuttani

    IPC分类号： A61M29/04

    CPC分类号： A61F5/0036 ,  A61F5/003 ,  A61F2210/0004 ,  A61F2210/0061

    摘要： The technology described herein provides methods for addressing obesity by introducing a device into the stomach. Embodiments of a device for treating obesity may comprise a shaped membrane construct that contains a swellable material. The construct may be contained within a capsule which is ingested by a patient. When the capsule dissolves in the stomach, the gastric secretions may diffuse through the membrane and spontaneously swell the internal material, which swells and stiffens the construct sufficiently to create a sensation of satiety by both filling gastric volume and by distending the walls of the stomach. The volume of the construct may be sufficient to prevent passage through the pyloric sphincter. After a set period of time or after the administration of a degradation formulation, the device may structurally degrade to allow passage through the pyloric sphincter and eventual passage from the body.

    摘要翻译： 本文所述的技术提供了通过将装置引入胃来解决肥胖症的方法。 用于治疗肥胖症的装置的实施方案可以包含含有可溶胀材料的成形膜构造。 构建体可以包含在被患者摄取的胶囊内。 当胶囊溶解在胃中时，胃分泌物可以扩散通过膜并自发地膨胀内部材料，其膨胀并使构造物充分膨胀，从而通过充满胃体积和膨胀胃壁来增加饱腹感。 构建体的体积可能足以防止通过幽门括约肌。 在一段时间之后或在施用降解制剂后，该装置可在结构上降解以允许通过幽门括约肌并最终从身体通过。

    WEARABLE FLUID-SENSITIVE HYGIENE COMPLIANCE DEVICE
    10.
    发明申请
    WEARABLE FLUID-SENSITIVE HYGIENE COMPLIANCE DEVICE 审中-公开
    易感性流感卫生符合性装置

    公开(公告)号：US20110193703A1

    公开(公告)日：2011-08-11

    申请号：US12702253

    申请日：2010-02-08

    申请人： Adriana Payton ,  Gavin Braithwaite

    发明人： Adriana Payton ,  Gavin Braithwaite

    IPC分类号： G08B23/00

    CPC分类号： G08B21/245

    摘要： Described are systems having for sensing that a hygiene activity has commenced and alerting a user upon completion of a minimum hygiene compliance period for that activity. For example, a wearable wrist-band can include a fluid sensor, timing circuitry, a power source, and an indicator. The fluid sensor can begin a timer which is configured to correspond to a minimum length of time for a hygiene protocol, and the indicator can indicate to a user when the minimum length of time has passed and the hygiene condition satisfied.

    摘要翻译： 描述了用于感测卫生活动已经开始的系统，并且在该活动的最低卫生适应期完成后提醒用户。 例如，可戴式腕带可以包括流体传感器，定时电路，电源和指示器。 流体传感器可以开始定时器，其被配置为对应于卫生协议的最小时间长度，并且指示符可以在最短时间长度已经过去并且卫生条件满足时向用户指示。