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    COATED IMPLANTABLE MEDICAL DEVICE
    1.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层可植入医疗器械

    公开(公告)号：US20080183268A1

    公开(公告)日：2008-07-31

    申请号：US11965385

    申请日：2007-12-27

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees ,  Thomas G. Kozma ,  David D. Grewe ,  Darin G. Schaeffer ,  JiChao Sun

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees ,  Thomas G. Kozma ,  David D. Grewe ,  Darin G. Schaeffer ,  JiChao Sun

    IPC分类号： A61F2/82

    CPC分类号： A61F2/885 ,  A61F2/0077 ,  A61F2250/0068

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    COATED MEDICAL DEVICE
    4.
    发明申请
    COATED MEDICAL DEVICE 审中-公开
    涂层医疗器械

    公开(公告)号：US20110015725A1

    公开(公告)日：2011-01-20

    申请号：US12892177

    申请日：2010-09-28

    申请人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

    发明人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

    IPC分类号： A61F2/82

    摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

    摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

    Stent deployment device
    8.
    发明授权
    Stent deployment device 有权
    支架部署装置

    公开(公告)号：US09358141B2

    公开(公告)日：2016-06-07

    申请号：US11547020

    申请日：2005-03-22

    申请人： Scott E. Boatman ,  Michael C. Hoffa ,  Kimberly D. Roberts ,  Darin G. Schaeffer

    发明人： Scott E. Boatman ,  Michael C. Hoffa ,  Kimberly D. Roberts ,  Darin G. Schaeffer

    IPC分类号： A61F2/958 ,  A61F2/82

    CPC分类号： A61F2/958 ,  A61F2002/821

    摘要： A stent deployment device (110) is provided for deploying a stent in a lumen of a patient. The device can include a catheter (112), a first balloon (122) positioned near a distal end of the catheter and a second balloon (123) adjacent to the first balloon. Alternatively, the second balloon can be positioned over the first balloon. The device also includes an expandable stent (210) positioned over the first balloon and the second balloon. The first balloon comprises a semi-compliant material, a noncompliant material or a compliant material. Similarly, the second balloon comprises a semi-compliant material, a noncompliant material or a compliant material. The first balloon is expandable to a first diameter, while the second balloon can be expandable to a second diameter.

    摘要翻译： 提供支架展开装置（110）用于将支架展开在患者的内腔中。 该装置可以包括导管（112），定位在导管的远端附近的第一球囊（122）和邻近第一球囊的第二球囊（123）。 或者，第二气球可以位于第一气球上方。 该装置还包括位于第一球囊和第二球囊之上的可扩张支架（210）。 第一气囊包括半柔顺材料，不符合材料或柔顺材料。 类似地，第二气囊包括半柔顺材料，不合格材料或顺应性材料。 第一气囊可扩张至第一直径，而第二球囊可扩张至第二直径。

    Therapeutic agent delivery device with a dual balloon having distal taper apertures
    9.
    发明授权
    Therapeutic agent delivery device with a dual balloon having distal taper apertures 有权
    具有双气囊的治疗剂递送装置具有远端锥形孔

    公开(公告)号：US09132260B2

    公开(公告)日：2015-09-15

    申请号：US12825965

    申请日：2010-06-29

    申请人： Darin G. Schaeffer ,  William F. Moore

    发明人： Darin G. Schaeffer ,  William F. Moore

    IPC分类号： A61M25/10

    CPC分类号： A61M25/1011 ,  A61M25/104 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052

    摘要： The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed.

    摘要翻译： 本公开通常提供多个气囊组件，其被用作医疗装置的远侧区域的一部分，其能够将治疗剂递送到具有体液的身体容器中。 多球囊组件包括内球囊和外球囊。 外球囊还包括近端锥形区域，中间区域和远端锥形区域。 内球囊的膨胀导致外球囊的中间区域接触身体血管的内壁，从而阻塞通过体血管的流体流动。 近端锥形区域和远端锥形区域构造成使得它们不接触身体血管的内壁。 远端锥形和近端锥形区域中的一个具有多个孔，其构造成允许治疗剂以预定速率输送到体内容器。 还公开了一种结合本公开的多球囊组件的医疗装置，以及用于使用医疗装置和多气囊组件的方法。