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    Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives
    2.
    发明申请
    Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives 失效

    公开(公告)号：US20050090634A1

    公开(公告)日：2005-04-28

    申请号：US10807004

    申请日：2004-03-22

    申请人： Daniel Morse ,  David Kisailus ,  Kristian Roth

    发明人： Daniel Morse ,  David Kisailus ,  Kristian Roth

    IPC分类号： B01J21/08 ,  B01J31/00 ,  B01J31/02 ,  B01J37/36 ,  C01B33/12 ,  C08G77/02 ,  C08G77/06 ,  C08G77/08

    CPC分类号： C08G77/08 ,  B01J21/08 ,  B01J31/003 ,  B01J31/0235 ,  B01J31/0272 ,  B01J37/36 ,  C01B33/12 ,  C01B33/126 ,  C08G77/02 ,  C08G77/06

    摘要： The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica, polysiloxanes, polymetalloid-oxanes polymetallo-oxanes (metal oxides), polyorganometalloid oxanes, polyorganometallo oxanes, and the polyhydrido derivatives thereof, at about neutral pH. The nanostructure-directing catalysts have a nucleophilic functionality and a hydrogen-bonding acceptor group, and include: silicateins, enzymes that work by a mechanism functionally related to that of the silicateins; self-assembling peptides related to those synthesized and demonstrated capable of acting as biomimetic substitutes for the silicateins; non-peptide-based synthetic polymers containing a nucleophilic group and a hydrogen bonding amine such that the polymer functions by a mechanism of action related to that of the silicateins; materials having such chemical functionality as a nucleophilic group and or a hydrogen bonding amine which, acting in concert with nanoconfinement and or chemical functionality of the surface or matrix to which the functionality is attached, acts catalytically by a mechanism related to that of the silicateins; and small-molecule non-polymeric biomimetic catalysts that operate by the same mechanism as silicateins. The substrate is selected from groups consisting of silicon alkoxides, non-silicon metalloid alkoxides or metal alkoxides, and any organic, organometallic or hydrido derivatives of the foregoing; inorganic and organic oxygen-containing chelates of silicon, non-silicon metalloids or metals and any organic, organometallic or hydrido derivatives of the foregoing; and inorganic and organic esters of the hydoxides of silicon, non-silicon metalloids or metals and any organic, organometallic or hydrido derivatives of the foregoing; and inorganic and organic hydolyzable salts, complexes or conjugates of the hydroxides of silicon, non-silicon metalloids or metals and any organic, organometallic and hydrido derivates of the foregoing.

    Process to detect binding events on an electrode microarray using enzymes
    7.
    发明申请
    Process to detect binding events on an electrode microarray using enzymes 审中-公开
    使用酶检测电极微阵列上的结合事件的方法

    公开(公告)号：US20070231794A1

    公开(公告)日：2007-10-04

    申请号：US11232479

    申请日：2005-09-21

    申请人： Kilian Dill ,  John Cooper ,  Andrei Ghindilis ,  Kristian Roth

    发明人： Kilian Dill ,  John Cooper ,  Andrei Ghindilis ,  Kristian Roth

    IPC分类号： C12Q1/68 ,  G01N33/567 ,  G06F19/00

    CPC分类号： C12Q1/001 ,  C12Q1/6825 ,  C12Q1/6837 ,  G01N33/5438 ,  C12Q2565/607 ,  C12Q2563/125 ,  C12Q2537/149

    摘要： The present invention provides a process to detect binding events on an electrode microarray. A microarray is provided having addressable electrodes and two or more different types of capture complexes at sites corresponding to the electrodes. The capture complexes capture analytes. Enzymes are attached to form a reporter complex. Substrate solutions are sequentially contacted to make enzyme products that are detectable at the electrodes by a difference in the electrical response at electrodes having the enzyme product and those not having the enzyme product. The enzyme product may be a solid deposition product. The electrical properties of electrodes on the microarray are read for the presence of the enzyme product by sequentially switching each electrode held at a constant voltage to ground and then back to the constant voltage.

    摘要翻译： 本发明提供一种检测电极微阵列上的结合事件的方法。 提供了一种微阵列，其具有可寻址电极和两个或多个不同类型的俘获复合物在对应于电极的位置。 捕获复合物捕获分析物。 酶结合形成报告复合物。 依次接触底物溶液，以通过在具有酶产物的电极和不具有酶产物的电极上的电响应差异在电极处检测到酶产物。 酶产物可以是固体沉积产物。 通过将保持在恒定电压的每个电极顺序地切换到地，然后回到恒定电压，读取微阵列上的电极的电学性质以获得酶产物的存在。

    Open circuit potential amperometry and voltammetry
    10.
    发明申请
    Open circuit potential amperometry and voltammetry 有权
    开路电位电流分析法和伏安法

    公开(公告)号：US20050185447A1

    公开(公告)日：2005-08-25

    申请号：US11102089

    申请日：2005-04-07

    申请人： Werner Kuhr ,  David Bocian ,  Jonathan Lindsey ,  Kristian Roth

    发明人： Werner Kuhr ,  David Bocian ,  Jonathan Lindsey ,  Kristian Roth

    IPC分类号： G01N27/416 ,  G01N27/49 ,  G01N27/26 ,  G01N17/00

    CPC分类号： B82Y30/00 ,  B82Y10/00 ,  G01N27/3277

    摘要： This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g., amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g., a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g., from diffusion-based species in solution.

    摘要翻译： 本发明提供了改善电化学测量（例如电流分析法，伏安法等）中的信噪比（S / N）的方法。 特别地，描述了一种方法，其中法拉第电流与读取氧化还原活性物质的电荷（例如，自组装单层（SAM））相关的充电电流暂时解离。 该方法在本文中指定为开路电位电流分析法（OCPA），定量地读取结合到（电耦合到）电极表面的氧化还原物质的电荷，同时区分出现的充电电流和电流测量信号 ，例如，从溶液中的基于扩散的物质。