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    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes
    2.
    发明授权
    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes 失效
    药理活性的O-酰基-2,3-二芳基-3-卤代丙烯酰基肟

    公开(公告)号：US4056629A

    公开(公告)日：1977-11-01

    申请号：US716277

    申请日：1976-08-20

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    IPC分类号： A61K20060101 ,  A61K31/15 ,  A61K31/215 ,  A61K31/27 ,  C07C20060101

    CPC分类号： C07D417/04

    摘要： A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

    摘要翻译： 由式I（I）的O-酰基-2,3-二芳基-3-卤代 - 丙烯醛肟组成或含有其中X表示氯或溴原子的药​​物，R代表烷基，烯基， 或具有1至12个碳原子的芳基，芳氧基，芳基烷基，芳基烷氧基，芳基氨基或芳基烷基氨基，任选地被1或2个具有1至6个碳原子的烷基取代的烷氧基，链烯氧基或烷基氨基， R2，R3和R4相同或不同，各自表示氢原子，卤素原子或具有1至6个碳原子的烷基或烷氧基，其制备方法和治疗嘌呤病症的方法 代谢。

    6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
    5.
    发明授权
    6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia 失效
    6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-硫代氧甲基-4-羟基四氢吡喃-2-酮及相应的二羟基羧酸衍生物，盐和酯，以及治疗高胆固醇血症

    公开(公告)号：US5166171A

    公开(公告)日：1992-11-24

    申请号：US680613

    申请日：1991-04-02

    申请人： Heiner Jendralla ,  Gunther Wess ,  Wilhelm Bartmann ,  Gerhard Beck

    发明人： Heiner Jendralla ,  Gunther Wess ,  Wilhelm Bartmann ,  Gerhard Beck

    IPC分类号： C07C59/68 ,  C07C323/09 ,  C07D309/30

    CPC分类号： C07C59/68 ,  C07C323/09 ,  C07D309/30 ,  Y10S514/824

    摘要： 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.

    摘要翻译： 6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-噻吩氧基甲基-4-羟基四氢吡喃-2-酮以及相应的二羟基羧酸衍生物，盐和酯，用于制备这些化合物的方法，它们作为药物，药物制剂和 新型酚类和噻吩类化合物通式Ⅰ的化合物及其相应的式Ⅱ的开环二羟基羧酸，其中X，Y和Z具有给定的含义，其药理学上可容许的盐与碱和 描述了其药理学耐受的酯，制备这些化合物的方法，它们作为药物和药物制剂的用途。 还描述了其中X，Y和Z具有给定的含义的式III“III”的新型酚类和噻吩类。