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19 条记录 (耗时 0.027 秒)

    Electrostrictive actuator for scanned-probe microscope
    1.
    发明授权
    Electrostrictive actuator for scanned-probe microscope 失效
    扫描型显微镜用电致伸缩器

    公开(公告)号：US5831264A

    公开(公告)日：1998-11-03

    申请号：US736045

    申请日：1996-10-22

    申请人： Gordon M. Shedd ,  David J. Ray

    发明人： Gordon M. Shedd ,  David J. Ray

    IPC分类号： G01Q10/04 ,  H01L41/09 ,  H01J37/256 ,  H01J37/28 ,  H01L41/08

    CPC分类号： G01Q10/04 ,  B82Y35/00 ,  H01L41/092 ,  Y10S977/872

    摘要： The electrostrictive actuator device of the present invention, which controls relative movement in a scanned-probe microscope between the tip of a probe and the surface of a sample, comprises two thin-walled cylindrical members formed of electrostrictive material. The first cylindrical member, which is connected to the microscope, has on each of its inner and outer surfaces a conductive layer that forms at least one electrode. Applying voltages to the electrodes on the inner and outer surfaces of the first cylindrical member controls the two-dimensional X-Y horizontal relative movement between the probe tip and the sample surface. The second cylindrical member of the actuator device is coaxially connected at one end with the first cylindrical member and at its opposite end with the sample or the probe. Both the inner and outer surfaces of the second member have conductive layers, each of which forms an electrode. Applying voltages to the electrodes on the inner and outer surfaces of the second cylindrical member controls the Z-direction vertical relative movement of the probe tip on or near the sample surface. In preferred embodiments of the actuator device of the invention, either or both of the conductive layers on the inner and outer surfaces of the first cylindrical member may comprise two opposite pairs of spaced apart electrodes. Also in accordance with the invention, a scanned-probe microscope apparatus comprises a microscope and the just-described electrostrictive actuator device comprising first and second cylindrical members for controlling, respectively, X-Y horizontal and Z-direction vertical movements.

    摘要翻译： 本发明的电致伸缩致动器装置控制探针的尖端和样品表面之间的扫描探针显微镜中的相对运动，包括由电致伸缩材料形成的两个薄壁圆柱形构件。 连接到显微镜的第一圆柱形构件在其每个内表面和外表面上都具有形成至少一个电极的导电层。 向第一圆柱形构件的内表面和外表面上的电极施加电压控制探针尖端和样品表面之间的二维X-Y水平相对运动。 致动器装置的第二圆柱形构件在一端与第一圆柱形构件同轴连接，并且在其相对端与样品或探针同轴连接。 第二构件的内表面和外表面都具有导电层，每个导电层形成电极。 向第二圆柱形构件的内表面和外表面上的电极施加电压控制探针尖端在样品表面上或附近的Z方向垂直相对运动。 在本发明的致动器装置的优选实施例中，第一圆柱形构件的内表面和外表面上的导电层中的一个或两个可以包括两对间隔开的电极。 同样根据本发明，扫描探针显微镜装置包括显微镜和刚才描述的电致伸缩致动器装置，其包括用于分别控制X-Y水平和Z方向垂直运动的第一和第二圆柱形构件。

    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD
    5.
    发明申请
    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 失效
    无标签的高通量生物分子筛选系统和方法

    公开(公告)号：US20090247427A1

    公开(公告)日：2009-10-01

    申请号：US12480886

    申请日：2009-06-09

    申请人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    发明人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    IPC分类号： C40B60/12

    CPC分类号： G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

    摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

    摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

    Support device and stage assembly for a scanned-probe microscope
    7.
    发明授权
    Support device and stage assembly for a scanned-probe microscope 失效
    扫描显微镜的支撑装置和舞台组装

    公开(公告)号：US5847387A

    公开(公告)日：1998-12-08

    申请号：US711194

    申请日：1996-09-10

    申请人： Gordon M. Shedd ,  Kevin J. Owens

    发明人： Gordon M. Shedd ,  Kevin J. Owens

    IPC分类号： G01Q70/16 ,  G01B5/00 ,  G01Q30/18 ,  H01J37/20 ,  H01J37/00

    CPC分类号： G01Q30/18 ,  B82Y35/00 ,  G01B5/0002 ,  Y10S977/86

    摘要： A support device for a scanned-probe microscope comprises a horizontal base member and a vertical bridge member that are transverse to one another. The horizontal and vertical members are connected at their respective opposite ends by a common chord member extending between the ends. The device preferably includes means for attaching a scanned-probe microscope to a forward surface of the vertical bridge member. The support device preferably further includes one or more bracket members, each attached at one end to the rearward surface of the vertical bridge member and at the opposite end to a rearward surface of the chord member. Each bracket includes a section extending away from the chord member. The horizontal base member and the chord member each has an upper surface substantially coplanar with one another. The substantially coplanar upper surfaces together provide support for a readily separable sample plate. Further in accordance with the invention, a microscope stage assembly comprises the described support device and a readily separable sample plate.

    摘要翻译： 用于扫描探针显微镜的支撑装置包括彼此横向的水平基座构件和垂直桥构件。 水平和垂直构件在它们各自的相对端部处通过在端部之间延伸的共同弦构件连接。 该装置优选地包括用于将扫描探针显微镜附接到垂直桥构件的前表面的装置。 支撑装置优选地还包括一个或多个支架构件，每个支架构件的一端连接到垂直桥构件的后表面，并且在与弦构件的后表面相对的一端。 每个支架包括远离弦杆构件的部分。 水平底座构件和弦杆构件各自具有彼此基本共面的上表面。 基本上共面的上表面一起为容易分离的样品板提供支撑。 此外，根据本发明，显微镜台组件包括所描述的支撑装置和容易分离的样品板。

    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD
    8.
    发明申请
    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 审中-公开
    无标签的高通量生物分子筛选系统和方法

    公开(公告)号：US20120010105A1

    公开(公告)日：2012-01-12

    申请号：US13237316

    申请日：2011-09-20

    申请人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    发明人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    IPC分类号： C40B60/12 ,  C40B30/10 ,  C40B30/00

    CPC分类号： G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

    摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

    摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。