公开(公告)号：US09418825B2

公开(公告)日：2016-08-16

申请号：US14762916

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki Yasuda ,  Shinya Ito ,  Akira Fujii ,  Yasushi Terui

IPC: H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC classification number: H01J49/0445 ,  G01N30/724 ,  H01J49/165

Abstract: A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.

Abstract translation: 质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。 特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。 该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。 因此，期望的样品的电离稳定，并且测量再现性提高。

公开(公告)号：US10585089B2

公开(公告)日：2020-03-10

申请号：US15320406

申请日：2015-06-17

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto Nogami ,  Shinya Ito ,  Tadao Yabuhara

IPC: G01N35/02 ,  G01N33/543 ,  G01N15/12 ,  G01N30/72 ,  G01N33/82 ,  G01N35/08 ,  G01N35/10 ,  G01N15/00

Abstract: When using an immunological analysis method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring by spectroscopy, and a mass spectrometry method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring with a mass spectrometer, the amount of the complex flowing in the flow path for immunological analysis and the amount of the complex flowing in the flow path for mass spectrometry are unknown, so the substance being measured cannot be accurately quantified even when merging information obtained from immunological analysis and information obtained from mass spectrometry. The invention provides a mechanism for quantifying the complexes after formation of the complexes, on the flow path for mass spectrometry and the flow path for immunological analysis.

公开(公告)号：US10024828B2

公开(公告)日：2018-07-17

申请号：US14894633

申请日：2014-05-07

Applicant: Hitachi High-Technologies Corporation

Inventor： Jun Nunoshige ,  Shinya Ito ,  Hiroshi Nakano

IPC: B01J20/281 ,  B01J20/28 ,  B01D15/08 ,  G01N30/52 ,  B01J20/288 ,  B01J20/32 ,  G01N30/72 ,  G01N30/00 ,  G01N30/02

CPC classification number: G01N30/482 ,  B01D15/08 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3253 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/52 ,  G01N30/72 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/484

Abstract: An adsorbent which enables solid phase extraction of water-soluble molecules with high efficiency and excellent selectivity and an analysis system using the adsorbent, the adsorbent containing a structure represented by the formula I wherein R is a carrier component, the moiety other than R is a side-chain functional group, R and the benzene ring in the side-chain functional group are bonded directly or bonded through one or more atoms, R′ is selected from the group consisting of hydroxy group, alkoxy group, amino group, alkylamino group, thiol group and alkyl sulfide group, R″ is independently selected from the group consisting of hydroxy group, alkoxy group, alkyl group, amino group, alkylamino group, dialkylamino group, trialkylamino group, thiol group, alkyl sulfide group and hydrogen atom, x is an integer of zero or more and three or less, and n is the number of the side-chain functional groups contained in the carrier component.

公开(公告)号：US09885732B2

公开(公告)日：2018-02-06

申请号：US14911406

申请日：2014-06-24

Applicant: Hitachi High-Technologies Corporation

Inventor： Makoto Nogami ,  Shinya Ito ,  Tadao Yabuhara

IPC: G01N35/02 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  G01N1/28 ,  G01N35/04

CPC classification number: G01N35/025 ,  G01N33/54366 ,  G01N35/00871 ,  G01N35/1065 ,  G01N2001/2826 ,  G01N2035/0458

Abstract: An analysis device is provided with a first disk on which a sample container and disposable container can be disposed, a second disk on which a solid-phase extraction cartridge and disposable container can be disposed, a first probe capable of transferring a sample of the sample container disposed on the first disk or a solution of the disposable container disposed on the first disk to the solid-phase extraction cartridge or disposable container disposed on the second disk, and a second probe capable of transferring a reagent of a reagent container to the sample container or disposable container disposed on the first disk and the solid-phase extraction cartridge or disposable container disposed on the second disk. Sample preprocessing before solid-phase extraction processing takes place on the first disk.

公开(公告)号：US10794874B2

公开(公告)日：2020-10-06

申请号：US15730936

申请日：2017-10-12

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shinya Ito ,  Shigeo Muto

IPC: G01N30/20 ,  G01N30/24 ,  G01N35/08 ,  H01J49/04 ,  G01N30/72 ,  G01N30/00

Abstract: Provided herein is a sample injection method that enables efficient injection of a trace sample solution while reducing the measurement time. A sample solution is injected into a sample loop with air layers disposed on both sides of the sample solution, and the total amount of the sample solution, including the air layers, is injected into a detector. The start and the end of data collection are determined from the detection signal intensity changes that occur upon the air layers being injected into the detector, and the velocity of the flowing liquid is increased to reduce the measurement time. A washing solution is injected after the air layer to improve the washing efficiency and reduce the washing time.

公开(公告)号：US11385208B2

公开(公告)日：2022-07-12

申请号：US16083308

申请日：2016-03-07

Applicant: Hitachi High-Technologies Corporation

Inventor： Makoto Nogami ,  Shinya Ito

IPC: G01N30/20 ,  G01N30/38 ,  G01N30/14 ,  G01N30/28 ,  G01N30/72 ,  G01N30/32

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.