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公开(公告)号:US07678336B2
公开(公告)日:2010-03-16
申请号:US10583724
申请日:2004-12-17
申请人: Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
发明人: Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
CPC分类号: B01L3/502746 , B01L2200/0636 , B01L2200/0647 , G01N15/1404 , G01N15/1463 , G01N2015/0073 , G01N2015/1413
摘要: Disclosed is a focusing channel device which focuses fluid containing micro particles so that the micro particles flow in a line. The channel device comprises a nozzle formed by left and right walls each of which comprises an inclination surface. The cross sectional area in vertical direction decreases from the entrance of the nozzle toward the exit of the nozzle. The shape of cross sectional view in horizontal direction is asymmetric for the central line in the length direction. Using the focus channel device of the invention, the micro particles in the fluid are not combined with each other and passed through the channel one by one. Thus, blockage of the channel or combination and movement of two particles together does not occur.
摘要翻译: 公开了一种聚焦通道装置,其聚焦含有微粒子的流体,使得微粒子流动成一行。 通道装置包括由左右壁形成的喷嘴,每个壁包括倾斜表面。 垂直方向的横截面积从喷嘴的入口朝向喷嘴的出口减小。 水平方向的横截面形状对于长度方向的中心线是不对称的。 使用本发明的聚焦通道装置,流体中的微粒子不会彼此结合并逐个通过通道。 因此,不会发生通道或组合的堵塞和两个颗粒的移动。
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公开(公告)号:US20080304720A1
公开(公告)日:2008-12-11
申请号:US10583724
申请日:2004-12-17
申请人: Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
发明人: Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
CPC分类号: B01L3/502746 , B01L2200/0636 , B01L2200/0647 , G01N15/1404 , G01N15/1463 , G01N2015/0073 , G01N2015/1413
摘要: Disclosed is a focusing channel device which focuses fluid containing micro particles so that the micro particles flow in a line. The channel device comprises a nozzle formed by left and right walls each of which comprises an inclination surface. The cross sectional area in vertical direction decreases from the entrance of the nozzle toward the exit of the nozzle. The shape of cross sectional view in horizontal direction is asymmetric for the central line in the length direction. Using the focus channel device of the invention, the micro particles in the fluid are not combined with each other and passed through the channel one by one. Thus, blockage of the channel or combination and movement of two particles together does not occur.
摘要翻译: 公开了一种聚焦通道装置,其聚焦含有微粒子的流体,使得微粒子流动成一行。 通道装置包括由左右壁形成的喷嘴,每个壁包括倾斜表面。 垂直方向的横截面积从喷嘴的入口朝向喷嘴的出口减小。 水平方向的横截面形状对于长度方向的中心线是不对称的。 使用本发明的聚焦通道装置,流体中的微粒子不会彼此结合并逐个通过通道。 因此,不会发生通道或组合的堵塞和两个颗粒的移动。
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公开(公告)号:US07842157B2
公开(公告)日:2010-11-30
申请号:US10583149
申请日:2004-12-17
申请人: Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
发明人: Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
IPC分类号: B29C65/00
CPC分类号: B29C65/4895 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B29C59/14 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/54 , B29C65/548 , B29C66/02 , B29C66/028 , B29C66/1122 , B29C66/3022 , B29C66/53461 , B29C66/54 , B29C66/542 , B29C66/71 , B29C66/73161 , B29C66/8322 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0026 , B29L2031/756 , H01L25/046 , H01L2924/0002 , Y10T156/1064 , B29C59/16 , B29C65/00 , H01L2924/00 , B29K2067/003 , B29K2025/06
摘要: Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.
摘要翻译: 公开了一种用于制造塑料微芯片的上基板和下基板的方法,其包括上基板,下基板和具有预定高度的样品填充空间,用于在上基板和下基板之间填充样品。 根据该方法,通过在上基板和下基板之间引入有机溶剂来粘合上基板和下基板。 另外,本发明提供使用该方法制造微芯片的方法和根据该方法制造的微芯片。 根据本发明,可以容易且精确地粘合塑料微芯片的上下基板。
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公开(公告)号:US08900531B2
公开(公告)日:2014-12-02
申请号:US12916098
申请日:2010-10-29
申请人: Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
发明人: Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
IPC分类号: B01L99/00 , H01L25/04 , B29C65/08 , B29C65/54 , B29C65/00 , B01L3/00 , B29C59/14 , B29C65/02 , B29C65/14 , B29C65/16 , B29C65/48 , B29K23/00 , B29K25/00 , B29K33/00 , B29K69/00 , B29L31/00
CPC分类号: B29C65/4895 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B29C59/14 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/54 , B29C65/548 , B29C66/02 , B29C66/028 , B29C66/1122 , B29C66/3022 , B29C66/53461 , B29C66/54 , B29C66/542 , B29C66/71 , B29C66/73161 , B29C66/8322 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0026 , B29L2031/756 , H01L25/046 , H01L2924/0002 , Y10T156/1064 , B29C59/16 , B29C65/00 , H01L2924/00 , B29K2067/003 , B29K2025/06
摘要: Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.
摘要翻译: 公开了一种用于制造塑料微芯片的上基板和下基板的方法,其包括上基板,下基板和具有预定高度的样品填充空间,用于在上基板和下基板之间填充样品。 根据该方法,通过在上基板和下基板之间引入有机溶剂来粘合上基板和下基板。 另外,本发明提供使用该方法制造微芯片的方法和根据该方法制造的微芯片。 根据本发明,可以容易且精确地粘合塑料微芯片的上下基板。
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公开(公告)号:US20110044862A1
公开(公告)日:2011-02-24
申请号:US12916098
申请日:2010-10-29
申请人: Jun Keun CHANG , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
发明人: Jun Keun CHANG , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
IPC分类号: B01L3/00
CPC分类号: B29C65/4895 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B29C59/14 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/54 , B29C65/548 , B29C66/02 , B29C66/028 , B29C66/1122 , B29C66/3022 , B29C66/53461 , B29C66/54 , B29C66/542 , B29C66/71 , B29C66/73161 , B29C66/8322 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0026 , B29L2031/756 , H01L25/046 , H01L2924/0002 , Y10T156/1064 , B29C59/16 , B29C65/00 , H01L2924/00 , B29K2067/003 , B29K2025/06
摘要: Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.
摘要翻译: 公开了一种用于制造塑料微芯片的上基板和下基板的方法,其包括上基板,下基板和具有预定高度的样品填充空间,用于在上基板和下基板之间填充样品。 根据该方法,通过在上基板和下基板之间引入有机溶剂来粘合上基板和下基板。 另外,本发明提供使用该方法制造微芯片的方法和根据该方法制造的微芯片。 根据本发明,可以容易且精确地粘合塑料微芯片的上下基板。
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公开(公告)号:US20120003725A1
公开(公告)日:2012-01-05
申请号:US12667372
申请日:2008-11-21
申请人: Hyun Chang Lim , Jun Ha Park , Chang Seop Lee , Hyun Joo Jung , Ji Young Park , Chan Il Chung , Jun Keun Chang
发明人: Hyun Chang Lim , Jun Ha Park , Chang Seop Lee , Hyun Joo Jung , Ji Young Park , Chan Il Chung , Jun Keun Chang
CPC分类号: G01N35/00029 , B01L3/502723 , B01L3/502746 , B01L2300/0825 , B01L2300/087 , B01L2300/089 , B01L2400/0406 , B01L2400/086 , G01N33/5304 , G01N2035/00158
摘要: Disclosed is a microfluidic chip capable of accurately and quickly detecting presence of a trace amount of a target within a fluid sample. It has a channel structure comprising a sample inlet for feeding a sample therethrough, a first reservoir for primarily storing the sample therein, a second reservoir for secondarily storing the sample therein, a first reaction portion in which a target is conjugated with a label, a second reaction portion in which the labeled target undergoes a specific reaction, such as an antigen-antibody reaction, and a delaying portion, located between the first and the second reaction portion, for decreasing a flow rate of the sample.
摘要翻译: 公开了一种能够准确且快速地检测流体样品中痕量痕量目标的微流控芯片。 它具有通道结构,该通道结构包括用于将样品通过其中的样品入口,用于主要将样品储存在其中的第一储存器,用于在其中二次存储样品的第二储存器,其中靶标与标签共轭的第一反应部分, 第二反应部分,其中标记的靶经历诸如抗原 - 抗体反应的特异性反应,以及位于第一和第二反应部分之间的延迟部分,用于降低样品的流速。
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公开(公告)号:US08858897B2
公开(公告)日:2014-10-14
申请号:US12667372
申请日:2008-11-21
申请人: Hyun Chang Lim , Jun Ha Park , Chang Seop Lee , Hyun Joo Jung , Ji Young Park , Chan Il Chung , Jun Keun Chang
发明人: Hyun Chang Lim , Jun Ha Park , Chang Seop Lee , Hyun Joo Jung , Ji Young Park , Chan Il Chung , Jun Keun Chang
CPC分类号: G01N35/00029 , B01L3/502723 , B01L3/502746 , B01L2300/0825 , B01L2300/087 , B01L2300/089 , B01L2400/0406 , B01L2400/086 , G01N33/5304 , G01N2035/00158
摘要: Disclosed is a microfluidic chip capable of accurately and quickly detecting presence of a trace amount of a target within a fluid sample. It has a channel structure comprising a sample inlet for feeding a sample therethrough, a first reservoir for primarily storing the sample therein, a second reservoir for secondarily storing the sample therein, a first reaction portion in which a target is conjugated with a label, a second reaction portion in which the labeled target undergoes a specific reaction, such as an antigen-antibody reaction, and a delaying portion, located between the first and the second reaction portion, for decreasing a flow rate of the sample.
摘要翻译: 公开了一种能够准确且快速地检测流体样品中痕量痕量目标的微流控芯片。 它具有通道结构,该通道结构包括用于将样品通过其中的样品入口,用于主要将样品储存在其中的第一储存器,用于在其中二次存储样品的第二储存器,其中靶标与标签共轭的第一反应部分, 第二反应部分,其中标记的靶经历诸如抗原 - 抗体反应的特异性反应,以及位于第一和第二反应部分之间的延迟部分,用于降低样品的流速。
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公开(公告)号:US08834813B2
公开(公告)日:2014-09-16
申请号:US12729583
申请日:2010-03-23
申请人: Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
发明人: Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
CPC分类号: B01L3/5027 , B01L3/502723 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/089 , B01L2400/0406 , B01L2400/086
摘要: A fluid analysis chip includes a channel formed within the chip. The chip includes a sample inlet and a sample outlet communicating with an outside of the chip, where the sample inlet and the sample outlet communicate with each other through the closed channel. An expanding part of the channel is formed in a longitudinal direction of the channel in such a manner that a pair of inner walls of the channel define an inner surface of the expanding part, and the expanding part has a larger sectional area than the channel.
摘要翻译: 流体分析芯片包括形成在芯片内的通道。 芯片包括与芯片外部连通的样品入口和样品出口,其中样品入口和样品出口通过封闭通道彼此连通。 通道的扩展部分沿通道的纵向方向形成,使得通道的一对内壁限定扩张部分的内表面,并且扩张部分具有比通道更大的截面面积。
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公开(公告)号:US20110036152A1
公开(公告)日:2011-02-17
申请号:US12729583
申请日:2010-03-23
申请人: Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
发明人: Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
IPC分类号: G01N33/48
CPC分类号: B01L3/5027 , B01L3/502723 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/089 , B01L2400/0406 , B01L2400/086
摘要: Disclosed is a fluid analysis chip including a microchannel formed within the chip. The chip includes a sample and a sample outlet communicating with an outside of the chip, and has a structure where the sample inlet and the sample outlet communicate with each other through the closed channel. An expanding part formed in a longitudinal direction of a channel in such a manner that a pair of inner walls corresponding to each other has a larger sectional area at a part or a whole thereof is formed. Therefore, fluids, which pass through the channel adjacent to the expanding part, move while making contact with only another pair of inner walls of the channel, which correspond to each other.
摘要翻译: 公开了一种流体分析芯片,其包括形成在芯片内的微通道。 芯片包括与芯片的外部连通的样品和样品出口,并且具有样品入口和样品出口通过封闭通道彼此连通的结构。 形成在通道的纵向方向上的扩张部分,使得彼此对应的一对内壁在其一部分或全部具有较大的截面面积。 因此,通过邻近膨胀部的通道的流体在仅与通道对应的另一对内壁接触的同时移动。
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10.
公开(公告)号:US08828334B2
公开(公告)日:2014-09-09
申请号:US12667374
申请日:2008-07-23
申请人: Jun Ha Park , Chang Seop Lee , Hyun Chang Lim , Chan Il Chung , Jun Keun Chang
发明人: Jun Ha Park , Chang Seop Lee , Hyun Chang Lim , Chan Il Chung , Jun Keun Chang
CPC分类号: B01L3/502753 , B01L3/5027 , B01L2300/0681 , B01L2300/0825 , B01L2400/0406 , G01N33/491
摘要: Disclosed is a module for rapidly detecting analytes in fluids with high effectiveness and a chip having the module. The module includes a microchannel, which has a filtering zone for removing noise materials and a reaction zone wherein labeling reaction and immobilization reaction for detection of analytes are performed, sample fluid moving through the microchannel due to capillary floating. In a case where the chip having the module is used in detecting analytes in fluids, it is possible to minimize dead volume of sample fluid so that high effective volume ratio can be implemented. Therefore, the chip can be used in detecting analytes from the minimum amount of sample fluid.
摘要翻译: 公开了一种用于快速检测具有高效率的流体中的分析物和具有该模块的芯片的模块。 该模块包括具有用于去除噪声材料的过滤区和反应区的微通道,其中执行用于检测分析物的标记反应和固定反应,由于毛细管漂浮而移动通过微通道的样品流体。 在具有模块的芯片用于检测流体中的分析物的情况下,可以使样品流体的死体积最小化,从而可以实现高有效体积比。 因此,该芯片可用于从最小量的样品流体中检测分析物。
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