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    Chip Having Microchannel For Counting Specific Micro Particles Among Floating Micro Particle Mixture By Optical Means And A Method For Counting Micro Particles Using The Same
    4.
    发明申请
    Chip Having Microchannel For Counting Specific Micro Particles Among Floating Micro Particle Mixture By Optical Means And A Method For Counting Micro Particles Using The Same 审中-公开
    具有用于通过光学装置计数浮动微粒子混合物中的特定微粒子的微通道的芯片和用于计数使用其的微粒子的方法

    公开(公告)号：US20100112631A1

    公开(公告)日：2010-05-06

    申请号：US12522377

    申请日：2008-01-07

    申请人： Dae Sung Hur ,  Chanil Chung ,  Seung Hwa Jeon ,  Jun Keun Chang

    发明人： Dae Sung Hur ,  Chanil Chung ,  Seung Hwa Jeon ,  Jun Keun Chang

    IPC分类号： C12Q1/06

    CPC分类号： A61B5/0059 ,  A61B5/14546

    摘要： A microchannel chip for counting floating microparticles with an optical method is provided. The depth of the microchannel chip is made to be a depth of field such that a clear and sharp optical image of microparticles can be obtained, without necessarily diluting the microparticle mixture inside the microchannel. Consequently, a microparticle counting instrument can easily count microparticles shown on an optical image of the microchannel. Particularly, it enables to count more easily the number of CD3 cells CD4 cells or CD8 cells in white blood cells being stained, without lysing or diluting red blood cells. Therefore, the microchannel chip can advantageously used for counting the number of CD3 cells, CD4 cells or CD8 cells in blood of an AIDS patient to monitor the progression of AIDS.

    摘要翻译： 提供了一种用于用光学方法计数浮动微粒的微通道芯片。 使微通道芯片的深度成为景深，使得可以获得微粒的清晰和清晰的光学图像，而不必将微通道内的微粒混合物稀释。 因此，微粒计数装置可以容易地计数微通道的光学图像上所示的微粒。 特别地，它能够更容易地计数正在染色的白细胞中CD3细胞CD4细胞或CD8细胞的数量，而不会溶解或稀释红细胞。 因此，微通道芯片可以有利地用于计数艾滋病患者血液中的CD3细胞，CD4细胞或CD8细胞的数量，以监测AIDS的发展。

    Device for counting micro particles
    5.
    发明授权
    Device for counting micro particles 有权
    微粒计数装置

    公开(公告)号：US07411680B2

    公开(公告)日：2008-08-12

    申请号：US10565162

    申请日：2004-07-13

    申请人： Jun Keun Chang ,  Chanil Chung ,  Dae Sung Hur ,  Alexey Dan Chin-Yu ,  Seok Chung ,  Jeong Ku Hwang ,  Seung Hwa Jeon

    发明人： Jun Keun Chang ,  Chanil Chung ,  Dae Sung Hur ,  Alexey Dan Chin-Yu ,  Seok Chung ,  Jeong Ku Hwang ,  Seung Hwa Jeon

    IPC分类号： G01N33/48 ,  G01N21/63 ,  G01N33/557

    CPC分类号： G01N15/1475 ,  B01L3/5027 ,  G01N15/147 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/1486

    摘要： A device for counting micro particles is presented. The device comprises a light source; a chip containing micro particles; an object lens; a CCD camera; a counting part; and a shifter for shifting the position of the chip. It is easy to count the number of micro particles, such as red blood cells or somatic cells, by using the device. The shifter shifts the position of the chip by a predetermined distance at every predetermined time interval in order that a certain area adjacent to the area photographed just before is shifted to the point where the light is incident. Therefore, sub-areas on the chip are photographed successively. The counting part counts the number of micro particles in each sub-area, and adds them together to calculate the total number of micro particles in the samples.

    摘要翻译： 提出了一种用于计数微粒的装置。 该装置包括光源; 含有微粒的芯片; 物镜; CCD相机; 计数部分 以及用于移动芯片的位置的移位器。 通过使用该装置，容易计数微粒例如红细胞或体细胞的数量。 移位器以每隔预定时间间隔将芯片的位置移动预定距离，以使与之前拍摄的区域相邻的某个区域移动到光入射点。 因此，连续拍摄芯片上的子区域。 计数部分计算每个子区域中的微粒数，并将它们相加在一起计算样品中的微粒总数。

    Channel apparatus for focusing a fluid flow
    6.
    发明授权
    Channel apparatus for focusing a fluid flow 失效
    用于聚焦流体流的通道装置

    公开(公告)号：US07678336B2

    公开(公告)日：2010-03-16

    申请号：US10583724

    申请日：2004-12-17

    申请人： Jun Keun Chang ,  Jun Ha Park ,  Chanil Chung ,  Jung Kyung Kim

    发明人： Jun Keun Chang ,  Jun Ha Park ,  Chanil Chung ,  Jung Kyung Kim

    IPC分类号： B01L11/00 ,  G01N33/48 ,  G01N33/00 ,  C12Q1/02

    CPC分类号： B01L3/502746 ,  B01L2200/0636 ,  B01L2200/0647 ,  G01N15/1404 ,  G01N15/1463 ,  G01N2015/0073 ,  G01N2015/1413

    摘要： Disclosed is a focusing channel device which focuses fluid containing micro particles so that the micro particles flow in a line. The channel device comprises a nozzle formed by left and right walls each of which comprises an inclination surface. The cross sectional area in vertical direction decreases from the entrance of the nozzle toward the exit of the nozzle. The shape of cross sectional view in horizontal direction is asymmetric for the central line in the length direction. Using the focus channel device of the invention, the micro particles in the fluid are not combined with each other and passed through the channel one by one. Thus, blockage of the channel or combination and movement of two particles together does not occur.

    摘要翻译： 公开了一种聚焦通道装置，其聚焦含有微粒子的流体，使得微粒子流动成一行。 通道装置包括由左右壁形成的喷嘴，每个壁包括倾斜表面。 垂直方向的横截面积从喷嘴的入口朝向喷嘴的出口减小。 水平方向的横截面形状对于长度方向的中心线是不对称的。 使用本发明的聚焦通道装置，流体中的微粒子不会彼此结合并逐个通过通道。 因此，不会发生通道或组合的堵塞和两个颗粒的移动。

    Channel Apparatus for Focusing a Fluid Flow
    7.
    发明申请
    Channel Apparatus for Focusing a Fluid Flow 失效
    用于聚焦流体流动的通道装置

    公开(公告)号：US20080304720A1

    公开(公告)日：2008-12-11

    申请号：US10583724

    申请日：2004-12-17

    申请人： Jun Keun Chang ,  Jun Ha Park ,  Chanil Chung ,  Jung Kyung Kim

    发明人： Jun Keun Chang ,  Jun Ha Park ,  Chanil Chung ,  Jung Kyung Kim

    IPC分类号： G01N35/08 ,  B01L3/00 ,  G01N21/01 ,  G01N21/05

    CPC分类号： B01L3/502746 ,  B01L2200/0636 ,  B01L2200/0647 ,  G01N15/1404 ,  G01N15/1463 ,  G01N2015/0073 ,  G01N2015/1413

    摘要： Disclosed is a focusing channel device which focuses fluid containing micro particles so that the micro particles flow in a line. The channel device comprises a nozzle formed by left and right walls each of which comprises an inclination surface. The cross sectional area in vertical direction decreases from the entrance of the nozzle toward the exit of the nozzle. The shape of cross sectional view in horizontal direction is asymmetric for the central line in the length direction. Using the focus channel device of the invention, the micro particles in the fluid are not combined with each other and passed through the channel one by one. Thus, blockage of the channel or combination and movement of two particles together does not occur.

    摘要翻译： 公开了一种聚焦通道装置，其聚焦含有微粒子的流体，使得微粒子流动成一行。 通道装置包括由左右壁形成的喷嘴，每个壁包括倾斜表面。 垂直方向的横截面积从喷嘴的入口朝向喷嘴的出口减小。 水平方向的横截面形状对于长度方向的中心线是不对称的。 使用本发明的聚焦通道装置，流体中的微粒子不会彼此结合并逐个通过通道。 因此，不会发生通道或组合的堵塞和两个颗粒的移动。

    Device for counting micro particles
    8.
    发明申请
    Device for counting micro particles 有权
    微粒计数装置

    公开(公告)号：US20060187442A1

    公开(公告)日：2006-08-24

    申请号：US10565162

    申请日：2004-07-13

    申请人： Jun Chang ,  Chanil Chung ,  Dae Sung Hur ,  Alexey Dan Chin-Yu ,  Seok Chung ,  Jeong Ku Hwang ,  Seung Jeon

    发明人： Jun Chang ,  Chanil Chung ,  Dae Sung Hur ,  Alexey Dan Chin-Yu ,  Seok Chung ,  Jeong Ku Hwang ,  Seung Jeon

    IPC分类号： G01N33/48

    CPC分类号： G01N15/1475 ,  B01L3/5027 ,  G01N15/147 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/1486

    摘要： A device for counting micro particles is presented. The device comprises a light source; a chip containing micro particles; an object lens; a CCD camera; a counting part; and a shifter for shifting the position of the chip. It is easy to count the number of micro particles, such as red blood cells or somatic cells, by using the device. The shifter shifts the position of the chip by a predetermined distance at every predetermined time interval in order that a certain area adjacent to the area photographed just before is shifted to the point where the light is incident. Therefore, sub-areas on the chip are photographed successively. The counting part counts the number of micro particles in each sub-area, and adds them together to calculate the total number of micro particles in the samples.

    摘要翻译： 提出了一种用于计数微粒的装置。 该装置包括光源; 含有微粒的芯片; 物镜; CCD相机; 计数部分 以及用于移动芯片的位置的移位器。 通过使用该装置，容易计数微粒例如红细胞或体细胞的数量。 移位器以每隔预定时间间隔将芯片的位置移动预定距离，以使与之前拍摄的区域相邻的某个区域移动到光入射点。 因此，连续拍摄芯片上的子区域。 计数部分计算每个子区域中的微粒数，并将它们相加在一起计算样品中的微粒总数。

    Device for counting cells and method for manufacturing the same
    9.
    发明申请
    Device for counting cells and method for manufacturing the same 审中-公开
    用于计数细胞的装置及其制造方法

    公开(公告)号：US20060223165A1

    公开(公告)日：2006-10-05

    申请号：US10565079

    申请日：2004-07-13

    申请人： Jun Chang ,  Seok Chung ,  Chanil Chung ,  Hyun Bang ,  Han Sang Jo

    发明人： Jun Chang ,  Seok Chung ,  Chanil Chung ,  Hyun Bang ,  Han Sang Jo

    IPC分类号： C12M1/34 ,  B44C3/08

    CPC分类号： B82Y15/00 ,  G01N15/1456 ,  G01N33/49 ,  G01N2015/1486 ,  G02B21/34 ,  Y10T156/1039

    摘要： Disclosed are a device for counting cells and a method for manufacturing the device. The device comprises a transparent upper substrate and a transparent lower substrate. Fine lattice patterns for counting cells are formed on the lower substrate. A space for filling the sample, including cells, is provided between the upper substrate and the lower substrate. A hole for injecting the samples into the space for filling the samples is provided in the upper substrate. The device is disposable, and the cost of manufacturing the device is low. It is easy to fill the samples into the filling space and to count cells by using the device. The upper substrate and the lower substrate are bonded, and thus, no cover is required.

    摘要翻译： 公开了一种用于计数细胞的装置及其制造方法。 该装置包括透明上基板和透明下基板。 在下基板上形成用于计数单元的细晶格图案。 在上基板和下基板之间设置用于填充样品的空间，包括单元。 用于将样品注入用于填充样品的空间中的孔设置在上基板中。 该设备是一次性的，制造设备的成本低。 通过使用该装置，可以容易地将样品填充到填充空间中并对细胞进行计数。 上基板和下基板接合，因此不需要盖。

    Device having an optical part for analyzing micro particles
    10.
    发明授权
    Device having an optical part for analyzing micro particles 失效
    具有用于分析微粒子的光学部件的装置

    公开(公告)号：US07684042B2

    公开(公告)日：2010-03-23

    申请号：US11547479

    申请日：2004-11-03

    申请人： Jun Keun Chang ,  Alexey Dan Chin-Yu ,  Jung Kyung Kim ,  Chanil Chung ,  Sun Hee Lim

    发明人： Jun Keun Chang ,  Alexey Dan Chin-Yu ,  Jung Kyung Kim ,  Chanil Chung ,  Sun Hee Lim

    IPC分类号： G01N21/25

    CPC分类号： G01N15/1459 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1484 ,  G01N2015/0073 ,  G01N2015/008

    摘要： Disclosed is a micro particle analyzing device illuminating light to fluid including micro particles, reading the lights emitted from the micro particles at a signal processing reading section and thus analyzing the micro particles. The device comprises a light source section emitting light which will be illuminated to the fluid; a lens regulating an amount and a focal distance of the light emitted from the light source; and a concave mirror condensing light emitted from the micro particle to reflect it to the reading section wherein the concave mirror is formed with a hole so that the light of the light source section having passed through the lens can pass through the concave mirror. When analyzing the micro particles using the analyzing device according to the invention, the amounts of lights emitted from the micro particles according to up-and-down positions of the micro particles are not different.

    摘要翻译： 公开了一种微粒分析装置，其将包含微粒的光照射到包含微粒的流体中，读取在信号处理读取部从微粒发射的光，从而分析微粒。 该装置包括发射将被照射到流体的光的光源部分; 调节从光源发射的光量和焦距的透镜; 以及凹面镜，会聚从微粒子射出的光，以将其反射到读取部分，其中凹面镜形成有孔，使得已经穿过透镜的光源部分的光能通过凹面镜。 当使用根据本发明的分析装置对微粒子进行分析时，根据微粒的上下位置从微粒子发射的光量没有不同。