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1.发明申请公开(公告)号：US20130129796A1
公开(公告)日：2013-05-23
申请号：US13741901
申请日：2013-01-15
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。
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2.发明申请公开(公告)号：US20180169302A1
公开(公告)日：2018-06-21
申请号：US15896948
申请日：2018-02-14
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
IPC分类号： A61L27/50 , A61L27/26 , A61L31/14 , A61K9/00 , A61L27/54 , A61L27/38 , A61L31/00 , A61F2/44 , A61L27/56 , A61L27/18 , A61L31/06 , A61L27/58 , A61L31/16 , A61F2/02 , A61L31/04 , C08L67/04
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
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3.发明授权Methods and compositions for the treatment of open and closed wound spinal cord injuries 有权用于治疗开放性和闭合性伤口脊髓损伤的方法和组合物公开(公告)号：US08685434B2
公开(公告)日：2014-04-01
申请号：US13741901
申请日：2013-01-15
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
IPC分类号： A61F2/00
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。
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公开(公告)号：US20230321230A1
公开(公告)日：2023-10-12
申请号：US18190068
申请日：2023-03-24
发明人： Bowen Li , Allen Jiang , Robert S. Langer , Daniel G. Anderson
IPC分类号： A61K39/215 , C07K14/47 , A61K39/39 , C07K14/005
CPC分类号： A61K39/39 , A61K39/215 , C07K14/005 , C07K14/472 , A61K2039/53
摘要： Provided herein are, in various embodiments, methods and compositions comprising polynucleotides (e.g., mRNA) for eliciting an immune response. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of infectious disease treatment (e.g., mRNA vaccines). In still further embodiments, the disclosure provides methods and compositions for enhancing one or more vaccines, such as SARS-CoV-2 mRNA vaccines.
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公开(公告)号：US11684583B2
公开(公告)日：2023-06-27
申请号：US16080737
申请日：2017-12-08
IPC分类号： A61K9/50 , C08F220/56 , A61K47/34 , A61K9/51 , A61K38/19 , A61K31/58 , A61K47/54 , A61K47/58 , A61K9/00 , C08F220/54 , C08F224/00
CPC分类号： A61K9/5052 , A61K9/0024 , A61K9/5026 , A61K9/5036 , A61K9/5169 , A61K31/58 , A61K38/193 , A61K47/34 , A61K47/54 , A61K47/58 , C08F220/54 , C08F220/56 , C08F224/00
摘要： Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g., associated with the nanoparticles and/or thermoresponsive polymer.
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公开(公告)号：US20230181463A1
公开(公告)日：2023-06-15
申请号：US17925180
申请日：2021-05-14
发明人： Robert S. Langer , Carlo Giovanni Traverso , Ameya R. Kirtane , Aniket Wahane , Christina Karavasili
IPC分类号： A61K9/06 , A61K9/51 , A61K31/7052 , A61K31/7048 , A61K31/137 , A61K31/4985 , A61K47/14
CPC分类号： A61K9/06 , A61K9/5192 , A61K31/7052 , A61K31/7048 , A61K31/137 , A61K31/4985 , A61K47/14
摘要： The present disclosure provides oleogel and oleopaste compositions, as well as methods, kits, preparations, and methods of using the same. The oleogels and oleopastes presented herein include compositions comprising azithromycin, albendazole, lumefantrine, praziquantel, moxifloxacin, and ivermectin.
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公开(公告)号：US20230101335A1
公开(公告)日：2023-03-30
申请号：US17738843
申请日：2022-05-06
摘要： An ex vivo tissue composition comprising an isolated tissue explant and tissue graft is provided. Methods of making and using the tissue composition are also provided.
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公开(公告)号：US11547667B2
公开(公告)日：2023-01-10
申请号：US16544464
申请日：2019-08-19
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US11547347B2
公开(公告)日：2023-01-10
申请号：US16152785
申请日：2018-10-05
IPC分类号： A61B5/00 , A61B5/07 , A61B5/11 , H01L41/04 , H01L41/047 , H01L41/053 , H01L41/113 , H01L41/187 , H01L41/23 , H01L41/29 , H01L41/333 , G01L1/16 , G01L19/08 , G01L9/00
摘要： Improvements in ingestible electronics with the capacity to sense physiologic and pathophysiologic states have transformed the standard of care for patients. Yet despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we disclose an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantified its key behaviors in the GI tract by using computational modeling, and validated its functionality in awake and ambulating swine. Our piezoelectric devices can safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for diagnosing and treating motility disorders and for monitoring ingestion in bariatric applications.
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公开(公告)号：US11446239B2
公开(公告)日：2022-09-20
申请号：US17024148
申请日：2020-09-17
发明人： Minglin Ma , Daniel G. Anderson , Robert S. Langer , Omid Veiseh , Joshua Charles Doloff , Delai Chen , Christian J. Kastrup , Arturo Jose Vegas
摘要： Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
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