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公开(公告)号：US11911474B2
公开(公告)日：2024-02-27
申请号：US17141753
申请日：2021-01-05
Applicant: ModernaTX, Inc.
Inventor： Antonin De Fougerolles , Sayda M. Elbashir
IPC: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , C07K14/535 , C12N15/67 , C12N15/87 , C12N9/64 , A61K48/00
CPC classification number: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , A61K48/00 , C12N2310/335
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US20180112221A1
公开(公告)日：2018-04-26
申请号：US15611490
申请日：2017-06-01
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
IPC: C12N15/113 , G01N33/559 , C12P21/00 , C12N15/10 , C07H21/02 , C07K16/00 , C12N15/11 , C07H19/10 , C12N5/071 , C07K16/28
CPC classification number: A61K48/0066 , C07H19/10 , C07H21/02 , C07K16/00 , C07K16/2887 , C07K2317/24 , C12N5/0602 , C12N15/102 , C12N15/11 , C12N15/1136 , C12N15/1138 , C12N15/67 , C12N2310/3341 , C12N2310/335 , C12P21/00 , G01N33/559
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
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公开(公告)号：US20170348436A1
公开(公告)日：2017-12-07
申请号：US15403517
申请日：2017-01-11
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: A61K48/00 , A61K9/127 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/10 , C07K16/00 , C07K14/705 , C07K14/62 , C07K14/56 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , A61K47/54 , C07K14/47 , C07K14/435 , C07K14/005 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , C07K14/485 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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4.发明授权公开(公告)号：US09814760B2
公开(公告)日：2017-11-14
申请号：US14878400
申请日：2015-10-08
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C07H21/02 , C12N15/85 , A61K38/17 , C07K14/47 , C07K14/62 , A61K48/00 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , C07K14/435 , C12P21/00 , C07K14/485 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US09701965B2
公开(公告)日：2017-07-11
申请号：US14535484
申请日：2014-11-07
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
IPC: C12N15/11 , C12N15/13 , C12N15/10 , C12N15/88 , C12N15/113 , C07H19/10 , C12P21/00 , C07H21/02 , C12N5/071 , C07K16/00 , C07K16/28 , G01N33/559
CPC classification number: A61K48/0066 , C07H19/10 , C07H21/02 , C07K16/00 , C07K16/2887 , C07K2317/24 , C12N5/0602 , C12N15/102 , C12N15/11 , C12N15/1136 , C12N15/1138 , C12N15/67 , C12N2310/3341 , C12N2310/335 , C12P21/00 , G01N33/559
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
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Patent Agency Ranking
公开(公告)号：US09533047B2
公开(公告)日：2017-01-03
申请号：US14337513
申请日：2014-07-22
Applicant: ModernaTX, Inc.
Inventor： Antonin de Fougerolles , Sayda M. Elbashir
IPC: A61K47/18 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , A61K31/7088 , C12N15/87 , A61K31/7115 , C07K14/535 , C12N9/64 , A61K48/00
CPC classification number: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , C12N2310/335
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
Abstract translation: 提供了将生物学部分如修饰的核酸递送到细胞中以调节蛋白质表达的制剂，组合物和方法。 这样的组合物和方法包括递送生物部分，并且可用于生产蛋白质。
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公开(公告)号：US20210236655A1
公开(公告)日：2021-08-05
申请号：US16930720
申请日：2020-07-16
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
IPC: A61K48/00 , C12N15/113 , C07H21/02 , C07H19/10 , C12P21/00 , C12N5/071 , C12N15/10 , C12N15/11 , C07K16/00 , C07K16/28 , G01N33/559 , C12N15/67
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
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公开(公告)号：US10898574B2
公开(公告)日：2021-01-26
申请号：US15927730
申请日：2018-03-21
Applicant: ModernaTX, Inc.
Inventor： Antonin de Fougerolles , Sayda M. Elbashir
IPC: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , C07K14/535 , C12N15/67 , C12N15/87 , C12N9/64 , A61K48/00
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US20240252645A1
公开(公告)日：2024-08-01
申请号：US18417715
申请日：2024-01-19
Applicant: ModernaTx, Inc.
Inventor： Antonin DE FOUGEROLLES , Sayda M. Elbashir
IPC: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , C07K14/535 , C12N9/64 , C12N15/67 , C12N15/87 , A61K48/00
CPC classification number: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , A61K48/00 , C12N2310/335
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US11603399B2
公开(公告)日：2023-03-14
申请号：US15591820
申请日：2017-05-10
Applicant: ModernaTX, Inc.
Inventor： Stephen G. Hoge , Eric Yi-Chun Huang , Tirtha Chakraborty , Sayda M. Elbashir
IPC: C07K14/76 , C12N15/67 , C07K14/50 , C07K14/535 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/765 , C07K16/00 , A61K48/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
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