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公开(公告)号：US20250057954A1
公开(公告)日：2025-02-20
申请号：US18821057
申请日：2024-08-30
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Sayda M. ELBASHIR
IPC: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/64 , C12N15/67 , C12N15/87
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US20190255194A1
公开(公告)日：2019-08-22
申请号：US16289947
申请日：2019-03-01
Applicant: ModernaTX, Inc.
Inventor： Atanu ROY , Christopher R. CONLEE , Antonin DE FOUGEROLLES , Andrew W. FRALEY , Gabor BUTORA , Matthew STANTON
IPC: A61K48/00 , C12N15/87 , C07D498/22 , C07H19/06 , C12N15/11 , C07D487/16 , C07D487/04 , C07D473/40 , C07D473/38 , C07D473/34 , C07D473/30 , C07D473/18 , C07D473/16 , C07H19/23 , C07H19/20 , C07H19/167 , C07H19/14 , C07H19/10 , C07H19/067 , C07D239/54 , C07D405/04 , C07F9/6561 , C07F9/6558 , C07H19/16 , C12N15/67 , C07H21/02
Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
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公开(公告)号：US20250064937A1
公开(公告)日：2025-02-27
申请号：US18821068
申请日：2024-08-30
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Sayda M. ELBASHIR
IPC: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/64 , C12N15/67 , C12N15/87
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US20220395562A1
公开(公告)日：2022-12-15
申请号：US17127435
申请日：2020-12-18
Applicant: ModernaTX, Inc.
Inventor： Tirtha CHAKRABORTY , Stephane BANCEL , Stephen G. HOGE , Atanu ROY , Antonin DE FOUGEROLLES , Noubar B. AFEYAN
Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
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5.发明申请公开(公告)号：US20210299278A1
公开(公告)日：2021-09-30
申请号：US17020522
申请日：2020-09-14
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , C12N15/85 , C07K14/47 , C07K14/62 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , A61K38/17 , C07K14/435 , C12P21/00 , C07K14/485 , C07H21/02 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K47/54 , A61K9/14 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/515 , C07K16/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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Patent Agency Ranking
公开(公告)号：US20170368200A1
公开(公告)日：2017-12-28
申请号：US15425645
申请日：2017-02-06
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , A61K9/127 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/10 , C07K16/00 , C07K14/705 , C07K14/62 , C07K14/56 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , A61K47/54 , C07K14/47 , C07K14/435 , C07K14/005 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , C07K14/485 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20210386857A1
公开(公告)日：2021-12-16
申请号：US17141753
申请日：2021-01-05
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Sayda M. ELBASHIR
IPC: A61K47/18 , A61K31/7088 , C12N15/87 , A61K31/7115 , C12N15/67 , C07K14/535 , C12N9/64 , A61K38/19 , A61K38/48 , A61K47/22 , A61K47/28
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
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公开(公告)号：US20210308283A1
公开(公告)日：2021-10-07
申请号：US17032657
申请日：2020-09-25
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Atanu ROY
Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
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公开(公告)号：US20210077634A1
公开(公告)日：2021-03-18
申请号：US16811648
申请日：2020-03-06
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Justin GUILD
IPC: A61K48/00 , C12N15/85 , C07K14/47 , C07K14/62 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , A61K38/17 , C07K14/435 , C12P21/00 , C07K14/485 , C07H21/02 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K47/54 , A61K9/14 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/515 , C07K16/00
Abstract: The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
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公开(公告)号：US20200164038A1
公开(公告)日：2020-05-28
申请号：US16525145
申请日：2019-07-29
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Kristy M. WOOD , Sayda M. ELBASHIR , Noubar B. AFEYAN , Pedro VALENCIA , Jason P. SCHRUM
IPC: A61K38/19 , C07K14/535 , A61K31/7105 , C12N15/117 , A61K48/00 , C12P21/00 , A61K31/7088 , C07K2/00 , C12N15/88 , A61K9/16 , A61K9/127 , A61K9/00 , C12N15/00 , A61K38/48 , A61K9/14
Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
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