公开(公告)号：US12023371B2

公开(公告)日：2024-07-02

申请号：US17127435

申请日：2020-12-18

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin De Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  C12N15/67

CPC classification number: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

公开(公告)号：US10155029B2

公开(公告)日：2018-12-18

申请号：US15429532

申请日：2017-02-10

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin De Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

公开(公告)号：US20180318446A1

公开(公告)日：2018-11-08

申请号：US15905576

申请日：2018-02-26

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Jason P. Schrum ,  Alexander Aristarkhov

IPC: A61K48/00 ,  C07K14/47 ,  A61K45/06

CPC classification number: A61K48/005 ,  A61K45/06 ,  A61K48/0066 ,  C07K14/4723 ,  C12N2320/32

Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve a subject's heath or wellbeing.

公开(公告)号：US11377470B2

公开(公告)日：2022-07-05

申请号：US14776864

申请日：2014-03-13

Applicant: ModernaTX, Inc.

Inventor： William Joseph Issa ,  John Grant Aunins ,  Stephane Bancel

IPC: C07H21/02 ,  C07H1/06 ,  C08B37/00 ,  C12Q1/6806 ,  C12N15/10

Abstract: Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2′deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.

公开(公告)号：US20180291335A1

公开(公告)日：2018-10-11

申请号：US15815020

申请日：2017-11-16

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Antonin de Fougerolles ,  Susan Whoriskey ,  Tirtha Chakraborty ,  Eric Yi-Chun Huang

IPC: C12N5/071 ,  C12N15/67 ,  C12N9/02 ,  C12P21/00 ,  C07K14/535

Abstract: The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.

公开(公告)号：US10022425B2

公开(公告)日：2018-07-17

申请号：US15266791

申请日：2016-09-15

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Jason P. Schrum ,  Alexander Aristarkhov

IPC: A61K49/00 ,  A61K39/00 ,  A61K39/38 ,  A61K38/17 ,  C07K14/47 ,  A61K45/06 ,  A61K38/46 ,  A61K48/00

Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.

公开(公告)号：US09878056B2

公开(公告)日：2018-01-30

申请号：US14390103

申请日：2013-03-09

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Eric Yi-Chun Huang

IPC: C07K14/47 ,  A61K48/00 ,  A61K31/7115 ,  A61K9/127 ,  C12N9/64 ,  C07K14/515 ,  C07K16/00 ,  C07K14/535 ,  A61K38/17 ,  A61K38/45 ,  C07K14/005 ,  C07K14/435 ,  C07K14/485 ,  C07K14/505 ,  C07K14/62 ,  C07K14/705 ,  C12N9/10 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/88 ,  C12N9/00 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  A61K9/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C07K14/525 ,  C07K14/56 ,  A61K9/14 ,  A61K47/54 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/005 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/485 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/56 ,  C07K14/62 ,  C07K14/705 ,  C07K16/00 ,  C12N9/1051 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/644 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y304/21022 ,  C12Y603/02019

Abstract: The invention relates to cosmetic mRNAs encoding elastin, and methods of using such mRNAs.

公开(公告)号：US20170348436A1

公开(公告)日：2017-12-07

申请号：US15403517

申请日：2017-01-11

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin de Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: A61K48/00 ,  A61K9/127 ,  C12P21/00 ,  C12P13/04 ,  C12N15/87 ,  C12N15/85 ,  C12N15/52 ,  C12N15/11 ,  C12N9/00 ,  C12N9/88 ,  C12N9/64 ,  C12N9/42 ,  C12N9/24 ,  C12N9/16 ,  C12N9/10 ,  C07K16/00 ,  C07K14/705 ,  C07K14/62 ,  C07K14/56 ,  C07K14/535 ,  C07K14/525 ,  C07K14/515 ,  C07K14/505 ,  A61K47/54 ,  C07K14/47 ,  C07K14/435 ,  C07K14/005 ,  A61K38/48 ,  A61K38/45 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  A61K38/17 ,  A61K31/7115 ,  A61K9/51 ,  A61K9/14 ,  C07K14/485 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y113/12007 ,  C12Y116/03001 ,  C12Y207/07012 ,  C12Y304/21007 ,  C12Y304/21022 ,  C12Y304/21027 ,  C12Y403/02001 ,  C12Y603/02019 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/491

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US09814760B2

公开(公告)日：2017-11-14

申请号：US14878400

申请日：2015-10-08

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin de Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: C07H21/02 ,  C12N15/85 ,  A61K38/17 ,  C07K14/47 ,  C07K14/62 ,  A61K48/00 ,  A61K31/7115 ,  C12N9/88 ,  A61K9/127 ,  C12N15/11 ,  C07K14/705 ,  C07K14/505 ,  C07K14/535 ,  C12N9/64 ,  C12N9/10 ,  C12N9/00 ,  C12N9/42 ,  C12N15/87 ,  C12P13/04 ,  A61K38/45 ,  C07K14/005 ,  C12N9/16 ,  C12N9/24 ,  C12N15/52 ,  C07K14/435 ,  C12P21/00 ,  C07K14/485 ,  C07K14/475 ,  C07K14/495 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/745 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N9/12 ,  C12N9/68 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y113/12007 ,  C12Y116/03001 ,  C12Y207/07012 ,  C12Y304/21007 ,  C12Y304/21022 ,  C12Y304/21027 ,  C12Y403/02001 ,  C12Y603/02019 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/491

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US09597380B2

公开(公告)日：2017-03-21

申请号：US14043927

申请日：2013-10-02

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin de Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C12N15/67

CPC classification number: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.