公开(公告)号：US10466264B2

公开(公告)日：2019-11-05

申请号：US14530863

申请日：2014-11-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Borja Bammesberger ,  Andreas Ernst ,  Peter Koltay ,  Nadine Losleben ,  Laurent Tanguy

IPC: B01L3/02 ,  G01N35/10 ,  B05B17/06 ,  B05C5/02 ,  B05B1/02

Abstract: A dispensing assembly comprising a cartridge holder is presented. The cartridge holder can receive a cartridge for dispensing a fluid. The cartridge can comprise a reservoir for receiving the fluid. The reservoir can comprise an outlet. The reservoir can have an adjustable volume for forcing the fluid through the outlet. The cartridge can further comprise a nozzle for dispensing the fluid. The nozzle can be connected to the outlet. The dispensing assembly can further comprise an actuator for actuating the adjustable volume. The dispensing assembly can further comprise an impulse generator for imparting an impulse to the nozzle. The impulse generator can comprise an actor for contacting the nozzle. The dispenser assembly can further comprise a controller for controlling the actor and the impulse generator.

公开(公告)号：US09469464B2

公开(公告)日：2016-10-18

申请号：US14530861

申请日：2014-11-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Timo Klein ,  Peter Koltay ,  Nadine Losleben ,  Juergen Spinke ,  Chris Steinert

IPC: B65D83/14 ,  B01L3/02 ,  B01L3/00 ,  G01N35/10

CPC classification number: B65D83/14 ,  B01L3/0265 ,  B01L3/502738 ,  B01L3/505 ,  B01L3/523 ,  B01L3/527 ,  B01L2300/123 ,  B01L2400/0611 ,  G01N35/1016

Abstract: A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. At least the second check valve is a duckbill valve. The second check valve is located at the second end of the conduit. The second check valve has sealing lips that extend beyond the second end of the conduit.

Abstract translation: 呈现用于分配流体的分配器。 分配器包括可压缩弹性体流体导管，其具有第一端和用于使流体从第一端流到第二端的第二端，在导管中间隔开形成流体室的第一止回阀和第二止回阀，以及 演员，用于压缩流体室以分配一部分流体。 至少第二止回阀是鸭嘴阀。 第二止回阀位于导管的第二端。 第二止回阀具有延伸超出导管第二端的密封唇。

公开(公告)号：US20180071740A1

公开(公告)日：2018-03-15

申请号：US15819165

申请日：2017-11-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thorsten Brueckner ,  Nadine Losleben ,  Norbert Oranth

IPC: B01L3/00 ,  G01N35/10

CPC classification number: B01L3/523 ,  B01F3/12 ,  B01F15/0462 ,  B01L3/502 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0867 ,  B01L2400/0478 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N33/5304 ,  G01N35/1002 ,  G01N2035/00574

Abstract: A method of dispensing a particle mixture and a reagent fluid cartridge are presented. The cartridge comprises a first reservoir partially filled with reagent fluid, a second reservoir partially filled with particles, a pumping chamber, a first pumping chamber conduit connecting the first reservoir and the pumping chamber, a second pumping chamber conduit connecting the second reservoir and the pumping chamber, an outlet for dispensing reagent fluid and particles from the cartridge, an outlet conduit connecting the outlet to the pumping chamber, and a valve sealing the outlet conduit. The method comprises closing the valve, applying a force to the plunger to transport a first defined volume of reagent fluid and second defined volume of particles into the pumping chamber to form a mixture of reagent fluid and particles, opening the valve, and forcing the mixture from the pumping chamber using the plunger to dispense the mixture from the outlet.

公开(公告)号：US20160216289A1

公开(公告)日：2016-07-28

申请号：US15092806

申请日：2016-04-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manfred Augstein ,  Nadine Losleben ,  Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: G01N35/10 ,  B01L3/00 ,  G01N35/00

CPC classification number: G01N35/1002 ,  B01L3/021 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/02 ,  B01L2300/042 ,  B01L2300/0609 ,  B01L2300/0663 ,  B01L2300/123 ,  B01L2400/0481 ,  G01F11/082 ,  G01F11/086 ,  G01F11/088 ,  G01N35/00871 ,  G01N2035/1034

Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.

Abstract translation: 提供了使用自动分析仪对样品中的分析物进行测量的方法。 自动分析仪包括：用于分配流体的盒，用于执行测量的测量单元，用于接收样品的样品保持器和用于将流体从盒中抽出并进入样品架的泵。 盒包括：刚性部分，柔性囊和出口。 刚性部分包括连接到内腔的开口。 柔性气囊密封开口以从内腔形成流体室。 流体室至少部分地被流体填充。 泵连接到出口。 该方法包括：将样品放入样品架中，控制将流体从料筒泵送到样品架中，并使用测量单元进行分析物的测量。

公开(公告)号：US20150048119A1

公开(公告)日：2015-02-19

申请号：US14530861

申请日：2014-11-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Timo Klein ,  Peter Koltay ,  Nadine Losleben ,  Juergen Spinke ,  Chris Steinert

IPC: B65D83/14

CPC classification number: B65D83/14 ,  B01L3/0265 ,  B01L3/502738 ,  B01L3/505 ,  B01L3/523 ,  B01L3/527 ,  B01L2300/123 ,  B01L2400/0611 ,  G01N35/1016

Abstract: A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. At least the second check valve is a duckbill valve. The second check valve is located at the second end of the conduit. The second check valve has sealing lips that extend beyond the second end of the conduit.

Abstract translation: 呈现用于分配流体的分配器。 分配器包括可压缩弹性体流体导管，其具有第一端和用于使流体从第一端流到第二端的第二端，在导管中间隔开形成流体室的第一止回阀和第二止回阀，以及 演员，用于压缩流体室以分配一部分流体。 至少第二止回阀是鸭嘴阀。 第二止回阀位于导管的第二端。 第二止回阀具有延伸超出导管第二端的密封唇。

公开(公告)号：US10241124B2

公开(公告)日：2019-03-26

申请号：US15092806

申请日：2016-04-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manfred Augstein ,  Nadine Losleben ,  Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: C12M1/00 ,  G01N35/10 ,  B01L3/02 ,  G01F11/08 ,  B01L3/00 ,  G01N35/00

Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.