Modified hyaluronic acid for use in musculoskeletal tissue repair
    1.
    发明申请
    Modified hyaluronic acid for use in musculoskeletal tissue repair 有权
    用于肌肉骨骼组织修复的改性透明质酸

    公开(公告)号:US20050137163A1

    公开(公告)日:2005-06-23

    申请号:US10741511

    申请日:2003-12-19

    CPC分类号: C08B37/0072 A61K31/728

    摘要: The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and/or regeneration of muscoloskeletal tissue and that include a biodegradable, porous substrate made from a biodegradable, hydrophobic polymer, where the hyaluronic acid complex is substantially insoluble in water at room temperature, yet soluble in mixtures of organic and aqueous solvents in which the selected hydrophobic polymer is soluble.

    摘要翻译: 本发明包括透明质酸的一价碱金属盐和四烷基卤化铵的透明质酸配合物,其适用于与适用于修复和/或再生肌肉骨骼组织的组织支架结合,并且包括可生物降解的, 由可生物降解的疏水性聚合物制成的多孔基材,其中透明质酸络合物在室温下基本上不溶于水,但可溶于选择的疏水性聚合物可溶的有机和水性溶剂的混合物中。

    Tissue scaffolds for use in muscoloskeletal repairs
    2.
    发明申请
    Tissue scaffolds for use in muscoloskeletal repairs 有权
    组织支架用于麝香骨骼修复

    公开(公告)号:US20050147642A1

    公开(公告)日:2005-07-07

    申请号:US10742136

    申请日:2003-12-19

    摘要: The present invention includes a tissue scaffold suitable for use in repair and/or regeneration of musculoskeletal tissue when implanted in a body that includes a porous substrate made from a biodegradable, hydrophobic polymer having a modified hyaluronic acid complex dispersed on the surface of and/or, where the modified hyaluronic acid complex is insoluble in water, yet soluble in mixtures of organic and aqueous solvents in which the hydrophobic polymer is soluble.

    摘要翻译: 本发明包括一种组织支架,其适于在植入体内时用于肌肉骨骼组织的修复和/或再生,其包括由可分散在其表面上的具有改性透明质酸复合物的可生物降解的疏水性聚合物制成的多孔底物,和/或 其中改性的透明质酸络合物不溶于水,但可溶于有机和水性溶剂的混合物,其中疏水聚合物可溶于其中。

    Lactam polymer derivatives
    4.
    发明申请
    Lactam polymer derivatives 有权
    内酰胺聚合物衍生物

    公开(公告)号:US20060069235A1

    公开(公告)日:2006-03-30

    申请号:US10955214

    申请日:2004-09-30

    IPC分类号: C08G63/08

    摘要: Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

    摘要翻译: 内酰胺聚合物已经用硼氢化钠(NaBH 4 H 4)进行了改性,得到含有羟基官能团的内酰胺聚合物。 这些官能团可用于共价连接反应性基团,荧光探针,抗微生物剂,生物活性因子和药物。 作为医疗装置的组件,特别是眼科装置,更具体地说是隐形眼镜。 基于这些聚合物的水凝胶也可用于药物递送,组织工程和可植入装置领域的生物医学应用。

    LACTAM POLYMER DERIVATIVES
    5.
    发明申请
    LACTAM POLYMER DERIVATIVES 审中-公开
    LACTAM聚合物衍生物

    公开(公告)号:US20070290174A1

    公开(公告)日:2007-12-20

    申请号:US11780175

    申请日:2007-07-19

    IPC分类号: C08G63/08

    摘要: Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

    摘要翻译: 内酰胺聚合物已经用硼氢化钠(NaBH 4 H 4)进行了改性,得到含有羟基官能团的内酰胺聚合物。 这些官能团可用于共价连接反应性基团,荧光探针,抗微生物剂,生物活性因子和药物。 作为医疗装置的组件,特别是眼科装置,更具体地说是隐形眼镜。 基于这些聚合物的水凝胶也可用于药物递送,组织工程和可植入装置领域的生物医学应用。

    Dithiocarbonate-containing macromers and polymers derived therefrom
    10.
    发明申请
    Dithiocarbonate-containing macromers and polymers derived therefrom 有权
    含二硫代碳酸酯的大分子单体和衍生自其的聚合物

    公开(公告)号:US20070225460A1

    公开(公告)日:2007-09-27

    申请号:US11390124

    申请日:2006-03-27

    IPC分类号: C08F28/06

    CPC分类号: C08G65/334 C08G65/3344

    摘要: Dithiocarbonate-containing macromer that contain biodegradable or water-soluble segments, and polymers derived from the reaction of these dithiocarbonate-containing macromers, are disclosed. The polymers derived from these dithiocarbonate-containing macromers with biodegradable or water-soluble segments are useful in medical and pharmaceutical applications.

    摘要翻译: 公开了含有可生物降解或水溶性链段的含二硫代碳酸酯的大分子单体以及衍生自含这些含二硫代碳酸酯的大分子单体反应的聚合物。 衍生自具有可生物降解或水溶性链段的含二硫代碳酸酯的大分子单体的聚合物可用于医疗和药物应用。