摘要:
The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and/or regeneration of muscoloskeletal tissue and that include a biodegradable, porous substrate made from a biodegradable, hydrophobic polymer, where the hyaluronic acid complex is substantially insoluble in water at room temperature, yet soluble in mixtures of organic and aqueous solvents in which the selected hydrophobic polymer is soluble.
摘要:
The present invention includes a tissue scaffold suitable for use in repair and/or regeneration of musculoskeletal tissue when implanted in a body that includes a porous substrate made from a biodegradable, hydrophobic polymer having a modified hyaluronic acid complex dispersed on the surface of and/or, where the modified hyaluronic acid complex is insoluble in water, yet soluble in mixtures of organic and aqueous solvents in which the hydrophobic polymer is soluble.
摘要:
The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要:
Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.
摘要翻译:内酰胺聚合物已经用硼氢化钠(NaBH 4 H 4)进行了改性,得到含有羟基官能团的内酰胺聚合物。 这些官能团可用于共价连接反应性基团,荧光探针,抗微生物剂,生物活性因子和药物。 作为医疗装置的组件,特别是眼科装置,更具体地说是隐形眼镜。 基于这些聚合物的水凝胶也可用于药物递送,组织工程和可植入装置领域的生物医学应用。
摘要:
Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.
摘要翻译:内酰胺聚合物已经用硼氢化钠(NaBH 4 H 4)进行了改性,得到含有羟基官能团的内酰胺聚合物。 这些官能团可用于共价连接反应性基团,荧光探针,抗微生物剂,生物活性因子和药物。 作为医疗装置的组件,特别是眼科装置,更具体地说是隐形眼镜。 基于这些聚合物的水凝胶也可用于药物递送,组织工程和可植入装置领域的生物医学应用。
摘要:
The invention provides punctal plugs for the delivery of active agents. The plugs have a body throughout which at least one active agent is dispersed or that is coated with a polymeric material containing at least one active agent.
摘要:
The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal wetting agent. The present invention further relates to silicone hydrogel contact lenses comprising at least one oxygen permeable component, and an amount of reactive, hydrophilic polymeric internal wetting agent sufficient to impart wettability to said device.
摘要:
Crosslinked lactam polymers are disclosed. Specifically, lactam polymers having pendant acrylate groups are crosslinked via a Michael addition type acrylate reactant. The crosslinked lactam polymers are useful in medical and pharmaceutical applications. Also disclosed are methods for making hydroxyl-functionalized lactam polymer derivatives.
摘要:
The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要:
Dithiocarbonate-containing macromer that contain biodegradable or water-soluble segments, and polymers derived from the reaction of these dithiocarbonate-containing macromers, are disclosed. The polymers derived from these dithiocarbonate-containing macromers with biodegradable or water-soluble segments are useful in medical and pharmaceutical applications.