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    Tissue scaffolds for use in muscoloskeletal repairs
    1.
    发明申请
    Tissue scaffolds for use in muscoloskeletal repairs 有权
    组织支架用于麝香骨骼修复

    公开(公告)号：US20050147642A1

    公开(公告)日：2005-07-07

    申请号：US10742136

    申请日：2003-12-19

    申请人： Walter Laredo ,  Alireza Rezania ,  Mark Zimmerman

    发明人： Walter Laredo ,  Alireza Rezania ,  Mark Zimmerman

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61L27/38 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58

    CPC分类号： A61L27/3839 ,  A61F2210/0004 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08L5/08

    摘要： The present invention includes a tissue scaffold suitable for use in repair and/or regeneration of musculoskeletal tissue when implanted in a body that includes a porous substrate made from a biodegradable, hydrophobic polymer having a modified hyaluronic acid complex dispersed on the surface of and/or, where the modified hyaluronic acid complex is insoluble in water, yet soluble in mixtures of organic and aqueous solvents in which the hydrophobic polymer is soluble.

    摘要翻译： 本发明包括一种组织支架，其适于在植入体内时用于肌肉骨骼组织的修复和/或再生，其包括由可分散在其表面上的具有改性透明质酸复合物的可生物降解的疏水性聚合物制成的多孔底物，和/或 其中改性的透明质酸络合物不溶于水，但可溶于有机和水性溶剂的混合物，其中疏水聚合物可溶于其中。

    Modified hyaluronic acid for use in musculoskeletal tissue repair
    2.
    发明申请
    Modified hyaluronic acid for use in musculoskeletal tissue repair 有权
    用于肌肉骨骼组织修复的改性透明质酸

    公开(公告)号：US20050137163A1

    公开(公告)日：2005-06-23

    申请号：US10741511

    申请日：2003-12-19

    申请人： Walter Laredo ,  Alireza Rezania

    发明人： Walter Laredo ,  Alireza Rezania

    IPC分类号： A61K31/728 ,  C08B37/00 ,  C08B37/08

    CPC分类号： C08B37/0072 ,  A61K31/728

    摘要： The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and/or regeneration of muscoloskeletal tissue and that include a biodegradable, porous substrate made from a biodegradable, hydrophobic polymer, where the hyaluronic acid complex is substantially insoluble in water at room temperature, yet soluble in mixtures of organic and aqueous solvents in which the selected hydrophobic polymer is soluble.

    摘要翻译： 本发明包括透明质酸的一价碱金属盐和四烷基卤化铵的透明质酸配合物，其适用于与适用于修复和/或再生肌肉骨骼组织的组织支架结合，并且包括可生物降解的， 由可生物降解的疏水性聚合物制成的多孔基材，其中透明质酸络合物在室温下基本上不溶于水，但可溶于选择的疏水性聚合物可溶的有机和水性溶剂的混合物中。

    IMPLANTABLE MEDICAL DEVICE SEEDED WITH MAMMALIAN CELLS AND METHODS OF TREATMENT
    3.
    发明申请
    IMPLANTABLE MEDICAL DEVICE SEEDED WITH MAMMALIAN CELLS AND METHODS OF TREATMENT 审中-公开
    与哺乳动物细胞分离的可植入医疗装置和治疗方法

    公开(公告)号：US20060263408A1

    公开(公告)日：2006-11-23

    申请号：US11461223

    申请日：2006-07-31

    申请人： Alireza Rezania ,  Mark Zimmerman ,  Kevor TenHuisen

    发明人： Alireza Rezania ,  Mark Zimmerman ,  Kevor TenHuisen

    IPC分类号： A61F2/06

    CPC分类号： A61L27/56 ,  A61L27/38

    摘要： The present invention relates to an implantable medical device containing a porous scaffold which is seeded with at least one mammalian cell other than immune cells and which is disposed within the device, which device is suitable for the treatment of a mammalian disease, more specifically, diabetes mellitus.

    摘要翻译： 本发明涉及一种植入式医疗装置，其包含多孔支架，该多孔支架用至少一种不同于免疫细胞的哺乳动物细胞接种并且设置在该装置内，该装置适用于治疗哺乳动物疾病，更具体地说是糖尿病 mellitus。

    PLURIPOTENT CELLS
    6.
    发明申请
    PLURIPOTENT CELLS 有权
    PLUIPOTENT细胞

    公开(公告)号：US20090269845A1

    公开(公告)日：2009-10-29

    申请号：US12108872

    申请日：2008-04-24

    申请人： Alireza Rezania

    发明人： Alireza Rezania

    IPC分类号： C12N5/08 ,  C12N5/06

    CPC分类号： C12N5/0606 ,  C12N2500/02 ,  C12N2501/105 ,  C12N2501/16 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2533/90

    摘要： The present invention is directed to pluripotent cells that can be readily expanded in culture on tissue culture substrate that is not pre-treated with protein or an extracellular matrix, and do not require a feeder cell line. The present invention also provides methods to derive the pluripotent cell line from human embryonic stem cells.

    摘要翻译： 本发明涉及能够在不用蛋白质或细胞外基质预处理并且不需要饲养细胞系的组织培养基质上容易地在培养物中扩增的多能细胞。 本发明还提供了从人胚胎干细胞衍生多能细胞系的方法。

    Tissue scaffolds for use in muscoloskeletal repairs
    8.
    发明授权
    Tissue scaffolds for use in muscoloskeletal repairs 有权
    组织支架用于麝香骨骼修复

    公开(公告)号：US07625581B2

    公开(公告)日：2009-12-01

    申请号：US10742136

    申请日：2003-12-19

    申请人： Walter R. Laredo ,  Alireza Rezania ,  Mark C. Zimmerman

    发明人： Walter R. Laredo ,  Alireza Rezania ,  Mark C. Zimmerman

    IPC分类号： A61K9/14 ,  A61K31/70

    CPC分类号： A61L27/3839 ,  A61F2210/0004 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08L5/08

    摘要： The present invention includes a tissue scaffold suitable for use in repair and/or regeneration of musculoskeletal tissue when implanted in a body that includes a porous substrate made from a biodegradable, hydrophobic polymer having a modified hyaluronic acid complex dispersed on the surface of and/or, where the modified hyaluronic acid complex is insoluble in water, yet soluble in mixtures of organic and aqueous solvents in which the hydrophobic polymer is soluble.

    摘要翻译： 本发明包括一种组织支架，其适于在植入体内时用于肌肉骨骼组织的修复和/或再生，其包括由可分散在其表面上的具有改性透明质酸复合物的可生物降解的疏水性聚合物制成的多孔底物，和/或 其中改性的透明质酸络合物不溶于水，但可溶于有机和水性溶剂的混合物，其中疏水聚合物可溶于其中。

    Multi-compartment delivery system
    9.
    发明申请
    Multi-compartment delivery system 审中-公开
    多隔间输送系统

    公开(公告)号：US20060153894A1

    公开(公告)日：2006-07-13

    申请号：US11170410

    申请日：2005-06-29

    申请人： Ragae Ghabrial ,  Ramie Fung ,  Alireza Rezania ,  Janet Davis

    发明人： Ragae Ghabrial ,  Ramie Fung ,  Alireza Rezania ,  Janet Davis

    IPC分类号： A61K38/18 ,  A61F2/00

    CPC分类号： A61L27/38 ,  A61K35/44 ,  A61K38/1866 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61K2300/00

    摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

    摘要翻译： 本发明提供设计成有效地将多个生物实体组合用于组织工程的装置。 特别地，本发明提供了能够将诸如胰岛的细胞或簇的细胞与诸如血管生成生长因子等治疗性化合物结合用于移植目的的装置。 本发明的装置由至少两个独立设计并分开处理的隔室组成，以适应不同生物实体的要求。 本装置的隔室可以在植入之前或在植入时组合，使得从一个隔室释放的治疗剂为由另一隔室托管的细胞提供一些益处以促进或改善其增殖，分化，存活或功能。