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    Chromatography column cartridge system
    1.
    发明授权
    Chromatography column cartridge system 失效
    色谱柱系统

    公开(公告)号：US5194225A

    公开(公告)日：1993-03-16

    申请号：US238087

    申请日：1988-08-30

    申请人： Werner Muller ,  Friedhelm Eisenbeiss ,  Jochen Kinkel ,  Helmut Kohl

    发明人： Werner Muller ,  Friedhelm Eisenbeiss ,  Jochen Kinkel ,  Helmut Kohl

    IPC分类号： B01D15/08 ,  G01N30/30 ,  G01N30/52 ,  G01N30/60

    CPC分类号： G01N30/6021 ,  B01D15/22 ,  G01N2030/522 ,  G01N30/30 ,  G01N30/6026 ,  G01N30/6082 ,  G01N30/6091

    摘要： A chromatography column cartridge system comprised of an internal pressure-stable precision glass tube which can be filled with adsorbent and an external protection and/or temperature control jacket with column connection parts which can be screwed on. The column connection parts comprise a union nut which is screwed onto the protection and/or temperature control jacket. The union nut contains a milled nut and a plunger which seals the glass tube radially. Feed and discharge lines for the mobile phase pass through the column connection parts.

    摘要翻译： 一个色谱柱柱系统，包括一个内部压力稳定的精密玻璃管，可以填充吸附剂，外部保护和/或温度控制夹套可以连接柱连接部分。 柱连接部分包括螺纹连接到保护和/或温度控制护套上的联管螺母。 联管螺母包含铣削螺母和柱塞，其径向密封玻璃管。 流动相的进料和排放管线通过柱连接部件。

    Gearbox arrangement
    2.
    发明授权
    Gearbox arrangement 有权
    齿轮箱排列

    公开(公告)号：US09108618B2

    公开(公告)日：2015-08-18

    申请号：US13805358

    申请日：2011-06-27

    申请人： Werner Muller

    发明人： Werner Muller

    IPC分类号： B60W10/02 ,  B60K23/04 ,  B60K17/16 ,  B60W10/115 ,  B60W30/18 ,  F16H48/10

    CPC分类号： B60W10/023 ,  B60K17/165 ,  B60K23/04 ,  B60W10/115 ,  B60W30/18145 ,  B60W2540/18 ,  B60W2720/28 ,  B60W2720/406 ,  B60Y2200/22 ,  B60Y2200/41 ,  F16H48/10

    摘要： A gearbox arrangement (1), which is arranged in a drive train of a multi-axle land vehicle (2), in particular a commercial vehicle, or a similar means of transportation, wherein at least one of said axles is driven, wherein at least one planetary drive (8) is associated with each of the axle halves (5) of a driven axle. The gearbox arrangement comprises at least one sensor device (7) for detecting a steering manipulation on the vehicle (2) and a control device (6). In order to have a gearbox arrangement (1) available that establishes a reliable, simply designed connection between the drive motor and driven wheels (4) with little effort and enables reliable control of the particular wheels (4) in regard to rotational speed and torque during drive and during deceleration, and thus realizes a controllable rotational speed compensation during cornering and significantly reduces the diameter and the constructed size of the power-split gearbox in particular for vehicles (2) having a high axle torque, the axle halves (5) are driven synchronously without differential and the control device (6) is provided with a hydrostatic device (11) that can be manipulated, by which hydrostatic device each of the wheels (4) rolling without slip maintains its torque.

    摘要翻译： 一种齿轮箱装置（1），其布置在多轴陆地车辆（2）的传动系中，特别是商用车辆或类似的运输工具，其中至少一个所述车轴被驱动，其中在 至少一个行星驱动器（8）与从动轴的每个轴半部（5）相关联。 齿轮箱装置包括用于检测车辆（2）上的转向操纵的至少一个传感器装置（7）和控制装置（6）。 为了具有可用的齿轮箱装置（1），其能够以很小的努力在驱动马达和从动轮（4）之间建立可靠的，简单设计的连接，并且能够相对于转速和扭矩可靠地控制特定的车轮（4） 在驱动期间和减速期间，因此在转弯期间实现可控的转速补偿，并且显着地减小动力分配齿轮箱的直径和结构尺寸，特别是具有高轴转矩的车辆（2），轴半部（5） 在没有差速器的情况下同步地被驱动，并且控制装置（6）设置有可被操纵的静液压装置（11），通过该静液压装置，每个车轮（4）滚动而不滑动地保持其扭矩。

    Rnai-Based Method for Selecting Transfected Eukaryotic Cells
    3.
    发明申请
    Rnai-Based Method for Selecting Transfected Eukaryotic Cells 审中-公开
    基于Rnai的选择转染真核细胞的方法

    公开(公告)号：US20080120733A1

    公开(公告)日：2008-05-22

    申请号：US11629709

    申请日：2005-06-16

    申请人： Martin Hafner ,  Karina Nawrath ,  Werner Muller

    发明人： Martin Hafner ,  Karina Nawrath ,  Werner Muller

    IPC分类号： A01K67/027 ,  C12N15/87 ,  C12N5/02 ,  C12N5/00 ,  C12N5/04 ,  A01H1/00 ,  C12N15/00

    CPC分类号： C12N15/8218 ,  C12N15/63 ,  C12N15/8209 ,  C12N15/821

    摘要： The invention relates to a method for the production of a eukaryotic cell selectable by inactivation or reduction of an endogenous gene function, comprising the steps of (a) introduction of one or more vectors into the cell and (b) expression of a siRNA and preferably shRNA coded by the one or more vectors, directed against an endogenous selectable gene and inactivating same, said siRNA or shRNA being the transcription product of an RNAi selection cassette, the selection cassette comprising a section of at least 19 nucleotides of the transcribed region of the gene, said selection being operatively linked to a promoter and a transcription termination signal. Furthermore, the invention relates to a eukaryotic cell comprising an RNAi selection cassette which is directed against an endogenous selectable gene and inactivates the function of said gene; wherein the RNAi selection cassette comprises a section of the gene with a length of at least 19 nucleotides which is operatively linked to a promoter and a transcription termination signal. Moreover, the invention relates to methods for the production of a transgenic mammal, comprising the steps: (a) injection of the embryonic stem cell according to the invention or of an embryonic stem cell selected according to the method of the invention in blastocysts of a mammal, (b) transfer of the blastocysts into the uterus of a mammal, and (c) carrying the transgenic mammal to full term. Finally, the invention relates to a method for the production of a transgenic plant.

    摘要翻译： 本发明涉及通过灭活或还原内源基因功能来选择性地生产真核细胞的方法，其包括以下步骤：（a）将一种或多种载体导入细胞，和（b）表达siRNA，优选 由一个或多个载体编码的针对内源可选择基因并使其失活的shRNA，所述siRNA或shRNA是RNAi选择盒的转录产物，所述选择盒包含至少19个核苷酸的转录区的部分 基因，所述选择可操作地连接到启动子和转录终止信号。 此外，本发明涉及包含针对内源可选择基因并使所述基因的功能失活的RNAi选择盒的真核细胞; 其中所述RNAi选择盒包含长度为至少19个核苷酸的基因的一部分，其与启动子和转录终止信号有效连接。 此外，本发明涉及生产转基因哺乳动物的方法，其包括以下步骤：（a）根据本发明的胚胎干细胞或根据本发明的方法选择的胚胎干细胞在囊胚中的注射 哺乳动物，（b）将囊胚转移到哺乳动物的子宫中，和（c）将转基因哺乳动物全部携带。 最后，本发明涉及生产转基因植物的方法。

    Decomposition and modification of silicate and silicone by silase and use of the reversible enzyme
    5.
    发明申请
    Decomposition and modification of silicate and silicone by silase and use of the reversible enzyme 失效
    通过硅藻分解和改性硅酸盐和硅氧烷并使用可逆酶

    公开(公告)号：US20060029939A1

    公开(公告)日：2006-02-09

    申请号：US10530240

    申请日：2003-10-02

    申请人： Werner Muller ,  Heinz Schroder ,  Anatoli Krasko

    发明人： Werner Muller ,  Heinz Schroder ,  Anatoli Krasko

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16 ,  C12N15/74

    CPC分类号： C12N9/88 ,  C12P3/00

    摘要： Silicatein is an enzyme of silicate-forming organisms used for the synthesis of their silicate scaffold. The present invention relates to the use of highly-expressed and highly active recombinant silicatein, silicatein isolated from natural sources after gene induction as well as silicatein-fusion proteins for the synthesis of amorphous silicon dioxide (silicic acids and silicates), siloxanes as well as modification of these compounds and their technical use.

    摘要翻译： 硅酸盐是一种用于合成硅酸盐支架的硅酸盐形成生物的酶。 本发明涉及在基因诱导后从天然来源分离的高表达和高活性的重组硅酸蛋白，硅酸盐以及用于合成无定形二氧化硅（硅酸和硅酸盐），硅氧烷的硅酸盐融合蛋白以及硅氧烷 - 这些化合物的改性及其技术用途。

    Surgical microscope for conducting computer-supported stereotactic microsurgery and a method for operating the same
    6.
    发明授权
    Surgical microscope for conducting computer-supported stereotactic microsurgery and a method for operating the same 失效
    用于进行计算机支持的立体定向显微外科手术的手术显微镜及其操作方法

    公开(公告)号：US5657128A

    公开(公告)日：1997-08-12

    申请号：US670772

    申请日：1996-06-24

    申请人： Werner Muller ,  Joachim Luber

    发明人： Werner Muller ,  Joachim Luber

    IPC分类号： A61B90/20 ,  G01B9/04 ,  G02B21/00 ,  G02B21/22 ,  G02B21/36 ,  G01B11/14 ,  G01N21/00 ,  H04N7/18

    CPC分类号： G01B9/04 ,  G02B21/0012 ,  G02B21/22 ,  G02B21/361 ,  A61B90/10 ,  A61B90/20

    摘要： A defined determination of the field of view observed through a surgical microscope is made. To achieve this determination, the relative current position of the plane of the field of view to the position of an object detail of interest is detected in a sighting method with the aid of a position detection system operating according to the laser triangulation principle. As soon as the plane of the field of view and the object detail are coincident, then with the aid of detected optical system data, the position of the object detail with reference to the surgical microscope is determined and, with the detected coordinates of the surgical microscope, the position of the field of view is determined in space. The position detecting system required for this purpose operates on an optical basis and can be integrated into the optics of the surgical microscope.

    摘要翻译： 进行通过手术显微镜观察到的视野的确定的确定。 为了实现该确定，借助于根据激光三角测量原理操作的位置检测系统，以瞄准方法来检测视场平面相对于感兴趣的物体细节的位置的相对当前位置。 一旦观察平面和物体细节一致，则借助于检测到的光学系统数据，确定参考手术显微镜的物体细节的位置，并且利用检测到的外科手术坐标 显微镜，视野的位置是在太空中确定的。 为此目的所需的位置检测系统在光学基础上运行，并且可以集成到手术显微镜的光学元件中。

    ABS control with rear pressure rate reduction when front pressure and time conditions are met
    9.
    发明授权
    ABS control with rear pressure rate reduction when front pressure and time conditions are met 失效
    ABS控制，当前压力和时间条件满足时，后压力降低

    公开(公告)号：US5284385A

    公开(公告)日：1994-02-08

    申请号：US752555

    申请日：1991-09-04

    申请人： Elmar Muller ,  Werner Muller

    发明人： Elmar Muller ,  Werner Muller

    IPC分类号： B60T8/58 ,  B60T8/1761 ,  B60T8/1766 ,  B60T8/62 ,  B60T8/32

    CPC分类号： B60T8/1766

    摘要： Antilock control system wherein pressure at the front and rear axles is controlled in cycles which each include a pressure reduction followed by a build-up of the brake pressure in pulses having holding phases therebetween. When a build-up of brake pressure at the front axle exceeds a predetermined time, the rate of build-up at the rear axle is reduced. The system prevents too much pressure build-up at the rear axle during the dynamic load transfer which occurs when braking a vehicle having a high center of gravity relative to its wheel base.

    摘要翻译： PCT No.PCT / EP90 / 00204 Sec。 371日期1991年9月4日 102（e）1991年9月4日PCT PCT 1990年2月9日PCT公布。 出版物WO90 / 11916 日期为1990年10月18日。其中，前后轴的压力以周期为单位进行控制的非锁定控制系统，每个循环包括压力降低，随后在其间保持相位的脉冲中累积制动压力。 当前轴处的制动压力的累积超过预定时间时，后轴处的积聚速率降低。 在制动具有相对于其车轮底座的高重心的车辆时的动态载荷传递期间，该系统防止在后桥处产生过大的压力。

    Process and device for smoothing tubular, extensible material
    10.
    发明授权
    Process and device for smoothing tubular, extensible material 失效
    用于平滑管状可延展材料的工艺和装置

    公开(公告)号：US5261579A

    公开(公告)日：1993-11-16

    申请号：US950401

    申请日：1992-09-23

    申请人： Hans-Walter Propach ,  Werner Muller

    发明人： Hans-Walter Propach ,  Werner Muller

    IPC分类号： D06C5/00 ,  D06H3/16 ,  D06C7/00

    CPC分类号： D06H3/16 ,  D06C5/005

    摘要： A process and a device for smoothing tubular, extensible material with at least one closed end, especially for shaping stockings or tights, is described, with at least one apparatus to feed in and stretch the material on an elongated stretcher being provided, also with at least one apparatus to heat the material on the stretcher, such that the apparatus for feeding in and stretching the material has a gathering fixture to pre-gather the material and a stretching apparatus that has gripper elements to transfer the gathered-up material from the gathering fixture, that can be moved along the elongated stretcher in order to slip the gathered material onto the stretcher. This arrangement guarantees particularly gentle handling of the material, and uniform stretching on the stretcher.

    摘要翻译： 描述了一种用于使具有至少一个封闭端，特别是用于成形袜子或紧身衣的管状可延展材料平滑的工艺和装置，至少一种装置用于在提供的细长担架上进给和拉伸材料， 至少一个用于加热担架上的材料的装置，使得用于馈送和拉伸材料的装置具有聚集夹具以预先聚集材料，以及具有夹持元件的拉伸装置，用于将聚集的材料从聚集体 夹具，其可以沿着细长的担架移动，以将聚集的材料滑动到担架上。 这种布置保证材料特别温和地处理，并且在担架上均匀拉伸。