公开(公告)号：US09757559B2

公开(公告)日：2017-09-12

申请号：US15034220

申请日：2014-07-11

申请人： LIMITED LIABILITY COMPANY “MEDEL”

发明人： Victor Pavlovich Homutov ,  Mikhail Samuilovich Morgunov

IPC分类号： A61N1/10 ,  A61L27/50 ,  A61N1/20 ,  A61L27/34 ,  C08L27/18 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61N1/32

CPC分类号： A61N1/10 ,  A61L27/34 ,  A61L27/50 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/00 ,  A61L2430/02 ,  A61N1/205 ,  A61N1/326 ,  C08L27/18

摘要： The invention relates to electret implant and to electrotherapy using static electricity of electret coatings for treatment of arthrosis of different joints: knee, hip, and shoulder, including for the arthrosis treatment of small bones of arms and legs. The inventive electret implant includes an extended body with a proximal and a distal end. On surface of the body a dielectric coating in an electret state is formed. The implant, wherein its body is implemented as a rod, at the proximal end of which a frontal surface is formed, and the fixation device of the implant in the hole in the bone can be made at the distal end. The bushing, wherein on its outer surface a thread for its set is made in the hole in the bone, and on its inner surface a thread for fixation of the electret implant in the hole is made.

公开(公告)号：US09603973B2

公开(公告)日：2017-03-28

申请号：US14852790

申请日：2015-09-14

申请人： The Spectranetics Corporation

发明人： Eugene T. Michal ,  Matthew J. Pollman

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L33/00 ,  A61L29/14 ,  A61M25/10

CPC分类号： A61L29/085 ,  A61L29/148 ,  A61L29/16 ,  A61L33/0005 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2400/00 ,  A61L2420/06 ,  A61M25/10 ,  A61M25/1027 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081 ,  A61M2025/109 ,  C08L33/02

摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

公开(公告)号：US20170000930A1

公开(公告)日：2017-01-05

申请号：US15170618

申请日：2016-06-01

申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.

发明人： Syed F.A. HOSSAINY ,  Stephen D. PACETTI

IPC分类号： A61L31/14 ,  B29C45/72 ,  C08K5/00 ,  A61L31/06 ,  C08J3/18

CPC分类号： A61L31/141 ,  A61L31/06 ,  A61L31/148 ,  A61L2400/00 ,  B29C45/0053 ,  B29C45/72 ,  B29C71/0009 ,  B29C71/02 ,  B29C2071/0027 ,  B29C2071/022 ,  B29K2033/04 ,  B29K2067/04 ,  B29L2031/753 ,  C08J3/18 ,  C08J9/00 ,  C08J2207/10 ,  C08J2300/16 ,  C08K5/0016

摘要： Methods of making polymeric devices, such as stents, with one or more modifications such as addition of plasticizers, to improve processing, and the devices made by these methods.

摘要翻译： 制备聚合物装置（例如支架）的方法，具有一种或多种改性，例如添加增塑剂以改善加工，以及通过这些方法制备的装置。

公开(公告)号：US20160331875A1

公开(公告)日：2016-11-17

申请号：US15039136

申请日：2014-11-26

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Mark GRINSTAFF ,  Jonah Andrew KAPLAN ,  Julia WANG

IPC分类号： A61L31/14 ,  A61L29/14 ,  A61L29/16 ,  A61L27/54 ,  A61L31/16 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L31/10

CPC分类号： A61L31/14 ,  A61K9/5031 ,  A61K9/5146 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2400/00

摘要： The disclosure provides a drug delivery device that can release a drug or other molecule of interest in response to application of a mechanical force, such as tension, and methods of use thereof. The present disclosure provides a tension-responsive drug delivery device by exploiting a difference in mechanical properties between a drug-loaded core material and a supertiydrophobic barrier coating consisting of interconnected micro- and nano-sized particles formulated via the electrospraying of a mixture of biocompatible polymers.

摘要翻译： 本公开提供了药物递送装置，其可以响应于诸如张力的机械力的应用及其使用方法而释放药物或其他分子。 本公开提供了一种张力响应药物递送装置，其通过利用药物负载的核心材料和由互相连接的微米级和纳米级的颗粒组成的超疏水屏障涂层之间的机械性能的差异，所述互连的微米级和纳米级的颗粒通过电生物相容性聚合物的混合物 。

公开(公告)号：US09427341B2

公开(公告)日：2016-08-30

申请号：US14478025

申请日：2014-09-05

申请人： TERUMO KABUSHIKI KAISHA

发明人： Takeshi Baba

IPC分类号： A61F2/90 ,  A61F2/82 ,  A61L31/02 ,  A61L31/18 ,  C22C19/00 ,  C22C19/03 ,  C22C19/07 ,  C22C27/02 ,  C22C27/04 ,  C22C38/18 ,  C22C38/00 ,  A61L31/14

CPC分类号： A61F2/90 ,  A61F2/82 ,  A61F2250/0043 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/14 ,  A61L31/18 ,  A61L2400/00 ,  C22C19/00 ,  C22C19/03 ,  C22C19/07 ,  C22C27/02 ,  C22C27/025 ,  C22C27/04 ,  C22C38/00 ,  C22C38/18 ,  Y10T29/49826

摘要： A stent and method of exhibiting radiopaque properties in a stent are disclosed, which includes a stent main body that is made of a metal, and a radiopaque marker that is made of a complete solid solution alloy having a corrosion potential of ±200 mV of a corrosion potential of the metal of the stent main body.

摘要翻译： 公开了一种在支架中展现不透射线性质的支架和方法，其包括由金属制成的支架主体，以及由具有±200mV的腐蚀电位的完全固溶体合金制成的不透射线标记 支架主体金属的腐蚀电位。

公开(公告)号：US20150024192A1

公开(公告)日：2015-01-22

申请号：US14380196

申请日：2013-02-20

申请人： LIVEDO CORPORATION

发明人： Yoshihisa Ota ,  Motoko Nishida ,  Masatoshi Ikeuchi

IPC分类号： A61L15/60 ,  A61L15/24

CPC分类号： A61L15/60 ,  A61L15/24 ,  A61L15/46 ,  A61L2400/00 ,  Y10T428/249991 ,  C08L33/08

摘要： To provide an absorbent body and an absorbent article having excellent deodorization effect. The present invention provides an absorber comprising, a crosslinked polymer mainly composed of acrylic acid and having carboxyl groups thereof being at least partially neutralized as a water-absorbent resin powder, and an antibacterial cationic surfactant, wherein the antibacterial cationic surfactant is a compound neutralized with an acid having an acid dissociation constant pKa in water at 25 degrees centigrade in a range from 3.0 to 5.5.

摘要翻译： 提供具有优异除臭效果的吸收体和吸收性物品。 本发明提供一种吸收剂，其特征在于，所述吸收体包含主要由丙烯酸构成的交联聚合物，其羧基至少部分被中和作为吸水性树脂粉末和抗菌性阳离子表面活性剂， 在25摄氏度的水中酸分解常数pKa在3.0至5.5的范围内的酸。

公开(公告)号：US08858966B2

公开(公告)日：2014-10-14

申请号：US14177888

申请日：2014-02-11

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61K9/00 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61F2/02

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US20130129796A1

公开(公告)日：2013-05-23

申请号：US13741901

申请日：2013-01-15

申请人： Massachusetts Institute of Technology ,  Children s Medical Center Corporation

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/58 ,  A61L27/26

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US20090130423A1

公开(公告)日：2009-05-21

申请号：US12268195

申请日：2008-11-10

申请人： John P. Keady

发明人： John P. Keady

IPC分类号： B32B3/26

CPC分类号： A61L31/04 ,  A61F11/08 ,  A61L31/14 ,  A61L2400/00 ,  H04R1/10 ,  H04R17/00 ,  H04R25/00 ,  H04R25/652 ,  H04R2460/15 ,  H04R2499/11 ,  Y10T428/249953

摘要： At least one exemplary embodiment is directed to a device that includes a membrane and a collapsible electroactive polymer element, where the element is in an expanded configuration without voltage application and is in a collapsed configuration with a voltage application, where the element is covered by the membrane.

摘要翻译： 至少一个示例性实施例涉及包括膜和可折叠的电活性聚合物元件的装置，其中元件处于没有电压施加的膨胀构型并且处于具有电压施加的折叠构造中，其中元件被覆盖 膜。

公开(公告)号：US20080289729A1

公开(公告)日：2008-11-27

申请号：US12127413

申请日：2008-05-27

申请人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

发明人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

IPC分类号： C21D9/00 ,  A61F2/00

CPC分类号： A61L27/10 ,  A61F2/28 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/38 ,  A61F2/44 ,  A61F2002/30016 ,  A61F2002/30922 ,  A61F2002/30929 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0041 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00089 ,  A61F2310/00101 ,  A61F2310/00485 ,  A61F2310/00592 ,  A61F2310/00598 ,  A61F2310/00856 ,  A61L27/045 ,  A61L27/047 ,  A61L27/06 ,  A61L27/30 ,  A61L27/50 ,  A61L2400/00 ,  Y10T428/12611

摘要： The present invention relates to a new composition and medical implant made therefrom, the composition comprising a thick diffusion hardened zone, and preferably further comprising a ceramic layer. The present invention relates to orthopedic implants comprising the new composition, methods of making the new composition, and methods of making orthopedic implants comprising the new composition.

摘要翻译： 本发明涉及由其制成的新组合物和医用植入物，所述组合物包含厚扩散硬化区，并且优选还包含陶瓷层。 本发明涉及包括新组合物的矫形植入物，制备新组合物的方法，以及制备包含该新组合物的整形外科植入物的方法。