Patent search ipc:"C07K5/113" Page 1

1.

发明公开
PEPTIDE COMPOSITIONS FOR SLOWING DEGRADATION OF VITAMIN MINERAL SUPPLEMENTS, FOODS, PHARMACEUTICAL AND COSMETICS 审中-公开

公开(公告)号：US20240247028A1

公开(公告)日：2024-07-25

申请号：US18587445

申请日：2024-02-26

Applicant: Steven W. BAILEY , June E. AYLING

Inventor： Steven W. BAILEY , June E. AYLING

IPC: C07K5/075 , A23L33/15 , A23L33/16 , A23L33/18 , A61K8/64 , A61K9/20 , A61Q5/02 , A61Q5/12 , C07K5/093 , C07K5/113

CPC classification number: C07K5/0613 , A23L33/15 , A23L33/16 , A23L33/18 , A61K8/64 , A61K9/2063 , A61Q5/02 , A61Q5/12 , C07K5/0819 , C07K5/1021 , A23V2002/00 , A61K2800/52

Abstract: Compositions of foods, vitamin and mineral supplements, topical or oral drugs, and cosmetic products containing a small peptide or peptides for slowing degradation, for example by transition metals. The peptides are di, tri, tetra-, and/or penta-peptides containing two or more aspartic acid residues. The degradation of several of the vitamin and other constituents vitamin-mineral supplements can be considerably slowed by composition incorporating such peptides, particularly if soluble (and thus bioavailable) forms of copper and/or iron are also present. The peptides can be hydrolyzed by the normal digestive process thus releasing bound metals. Multiple aspartate peptide(s) compositions with foods, topical or oral drugs, cosmetic, and hair care products can replace synthetic chelating preservative agents. Methods are also described to effectively slow degradation and preserve the above products using multiple aspartate peptides.

2.

发明公开
CASPASE-3-TRIGGERED MOLECULAR SELF-ASSEMBLING PET PROBES AND USES THEREOF 审中-公开

公开(公告)号：US20240042068A1

公开(公告)日：2024-02-08

申请号：US18329245

申请日：2023-06-05

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Min Chen , Yunfeng Cheng , Jianghong Rao , Zixin Chen , Jinghang Xie

IPC: A61K51/08 , C07K5/113 , C07K5/103

CPC classification number: A61K51/088 , C07K5/1021 , C07K5/101

Abstract: Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.

3.

发明公开
DELIVERY OF ENDOTHELIAL CELL-LADEN MICROGEL ELICITS ANGIOGENESIS IN SELF-ASSEMBLING ULTRASHORT PEPTIDE HYDROGELS 审中-公开

公开(公告)号：US20230382948A1

公开(公告)日：2023-11-30

申请号：US18032351

申请日：2021-10-20

Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Charlotte A. E. HAUSER , Gustavo Andres RAMIREZ-CALDERON

IPC: C07K5/103 , C07K5/11 , C07K5/113 , C12N5/00

CPC classification number: C07K5/1013 , C07K5/1019 , C07K5/1021 , C12N5/0068 , C12N2531/00 , C12N2533/50 , C12N2535/00

Abstract: The present disclosure relates to a cell-laden microgel comprising self-assembly ultrashort peptide (SUP) and a method of frabricating such cell-laden microgels. The present disclosure also relates to a cell microcarrier comprising cell-laden microgels, which is suitable for medical applications such as cell therapy. The present disclosure further relates to a system comprising a combination of SUP microgel and SUP bulk hydrogel for vascularized tissue culture and a method of creating such a vascularized 3D tissue constructs with improved cell viability and proliferation.

4.

发明公开
SAPOSIN-A DERIVED PEPTIDES AND USES THEREOF 审中-公开

公开(公告)号：US20230285501A1

公开(公告)日：2023-09-14

申请号：US18103740

申请日：2023-01-31

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： Randolph S. Watnick

IPC: A61K38/08 , C07K7/06 , C07K5/113 , C07K16/00 , A61K38/07 , A61K39/395 , G01N33/50 , C12Q1/6886 , G01N33/74 , G01N33/68 , G01N33/574 , C07K5/11 , A61K45/06 , C07K14/475

CPC classification number: A61K38/08 , C07K7/06 , C07K5/1021 , C07K16/00 , A61K38/07 , A61K39/39591 , G01N33/5023 , C12Q1/6886 , G01N33/74 , G01N33/6893 , G01N33/574 , C07K5/1019 , A61K45/06 , C07K14/475 , C07K2319/30 , C07K2319/31 , A61K2039/505

Abstract: Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the peptide consists essentially of 4-6 mers identified as exhibiting the activity of prosaposin A. Also disclosed herein are therapeutic compositions comprising the polypeptides and fusion polypeptides, and their use in the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.

5.

发明公开
PROBIOTIC BACTERIAL MOLECULES AND THEIR USE IN METHODS TO TREAT/PREVENT INFECTION BY HARMFUL BACTERIA AND TO PROVIDE NUTRITIONAL HEALTH 审中-公开

公开(公告)号：US20230226139A1

公开(公告)日：2023-07-20

申请号：US18168163

申请日：2023-02-13

Applicant: UNIVERSITY OF GUELPH

Inventor： Mansel Griffiths , Maira Medellin-Pena , Veronique Delcenserie

IPC: A61K38/08 , C07K5/103 , A61K35/747 , A23K20/195 , A23L33/135 , C07K14/335 , A61K35/744 , C07K7/06 , C07K5/107 , C07K5/113 , A23K10/18 , A61K35/745 , A61K38/07

CPC classification number: A61K38/08 , C07K5/1005 , A61K35/747 , A23K20/195 , A23L33/135 , C07K14/335 , A61K35/744 , C07K7/06 , C07K5/1016 , C07K5/1021 , A23K10/18 , A61K35/745 , A61K38/07 , Y02A50/30

Abstract: This invention provides isolated and characterized secreted molecules from probiotic bacteria for use in compositions and methods for the treatment and/or prevention of infection by harmful pathogenic bacteria. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal.

6.

发明申请
PEPTIDOMIMETIC INHIBITORS OF B-CATENIN/TCF PROTEIN-PROTEIN INTERACTION 有权

公开(公告)号：US20220024977A1

公开(公告)日：2022-01-27

申请号：US17311623

申请日：2019-12-06

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： Haitao JI

IPC: C07K5/113 , A61P35/00

Abstract: Disclosed are inhibitors for the β-catenin/T-cell factor interaction. The inhibitors are selective for β-catenin/T-cell factor over β-catenin/phosphocadherin, and β-catenin/phosphoAPC interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.

7.

发明申请
SOLUTION PHASE SYNTHESIS OF BETA-TURN PEPTIDOMIMETIC CYCLIC SALTS 有权

公开(公告)号：US20210300966A1

公开(公告)日：2021-09-30

申请号：US17337383

申请日：2021-06-02

Applicant: MIMETOGEN PHARMACEUTICALS, INC.

Inventor： Sébastien Rocchi , Chantal Devin , Wei Tian , Martin Bohlin

IPC: C07K5/113 , C07K1/30 , C07K1/02 , C07K5/10

Abstract: The present disclosure relates to methods of preparing and crystallizing β-turn cyclic peptidomimetic salts of formula I: where R1, R2, R3, R4, R5, R6, R7, R8, R10, X, Y and n are as defined in the specification.
The present disclosure provides a more efficient route for preparing a crystalline form of a β-turn cyclic peptidomimetic compounds and salts thereof.

8.

发明授权
Methods and compositions for detecting or measuring caspases or apoptosis 有权

公开(公告)号：US10941435B2

公开(公告)日：2021-03-09

申请号：US16306609

申请日：2017-06-21

Applicant: Life Technologies Corporation

Inventor： Kyle Gee , Wenjun Zhou , Shih-Jung Huang , Monica Tomaszewski

IPC: C12Q1/37 , C07K5/103 , C07K5/113 , G01N21/64 , G01N33/58 , C12Q1/48

Abstract: Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase.