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1086 条记录 (耗时 0.049 秒)

    Systems and methods for virtual parallel computing using matrix product states
    91.
    发明授权
    Systems and methods for virtual parallel computing using matrix product states 有权
    使用矩阵产品状态的虚拟并行计算的系统和方法

    公开(公告)号：US09355363B2

    公开(公告)日：2016-05-31

    申请号：US13762278

    申请日：2013-02-07

    申请人： TRUSTEES OF BOSTON UNIVERSITY ,  UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

    发明人： Claudio Chamon ,  Eduardo R. Mucciolo

    IPC分类号： G06N99/00 ,  G06F17/16 ,  B82Y10/00 ,  G06F9/30

    CPC分类号： G06N99/002 ,  B82Y10/00 ,  G06F9/30029 ,  G06F17/16

    摘要： A virtual parallel computing system and method represents bits with matrices and computes over all input states in parallel through a sequence of matrix operations. The matrix operations relate to logic gate operators to carry out a function implementation that represents a problem to be solved. Initial matrices are prepared to encode the weights of all input states, which can be binary states. Intermediate results can be simplified to decrease computational complexity while maintaining useful approximation results. The final matrices can encode the answer(s) to the problem represented by the function implementation. The system and method are particularly useful in speeding up database searches and in counting solutions of satisfiability problems.

    摘要翻译： 虚拟并行计算系统和方法表示具有矩阵的位，并通过矩阵运算序列并行计算所有输入状态。 矩阵运算涉及逻辑门操作符，以执行表示要解决的问题的函数实现。 准备初始矩阵以对可以是二进制状态的所有输入状态的权重进行编码。 可以简化中间结果以减少计算复杂度，同时保持有用的近似结果。 最终的矩阵可以将函数编码到由函数实现表示的问题中。 该系统和方法在加速数据库搜索和计算可满足性问题的解决方案中特别有用。

    Biological circuit chemotactic converters
    93.
    发明授权
    Biological circuit chemotactic converters 有权
    生物电路趋化转换器

    公开(公告)号：US09284562B2

    公开(公告)日：2016-03-15

    申请号：US13512453

    申请日：2010-11-30

    申请人： James J. Collins ,  Timothy Kuan-Ta Lu

    发明人： James J. Collins ,  Timothy Kuan-Ta Lu

    IPC分类号： C12N15/00 ,  C12N15/09 ,  C07H21/04 ,  C12Q1/68 ,  H03M1/66 ,  H03M1/12 ,  C12N15/63

    CPC分类号： C12N15/63 ,  C12N15/635

    摘要： Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis in cellular systems. Flexibility in these biological circuit chemotactic converter is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create network systems that regulate chemotactic responses based on the combination and nature of input signals received.

    摘要翻译： 这里描述的是利用诸如遗传拨动开关和单一转换存储器模块（SIMM）等模块化组件的新型生物电路趋化转换器，用于检测和转换诸如化学引诱剂的外部输入到允许在细胞系统中自主趋化的输出。 这些生物电路趋化转换器的灵活性通过将各个模块化组件即SIMM和遗传拨动开关组合在一起来提供。 这些生物转换器开关可以组合在各种网络拓扑中，以创建基于所接收的输入信号的组合和性质来调节趋化反应的网络系统。

    Optoelectronic Control Of Solid-State Nanopores
    94.
    发明申请
    Optoelectronic Control Of Solid-State Nanopores 审中-公开
    固态纳米孔的光电子控制

    公开(公告)号：US20160033471A1

    公开(公告)日：2016-02-04

    申请号：US14775217

    申请日：2014-03-14

    申请人： THE TRUSTEES OF BOSTON UNIVERSITY

    发明人： Amit MELLER ,  Nicolas Di FIORI

    IPC分类号： G01N33/487 ,  G01N21/63 ,  G01N27/49

    CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  G01N21/63 ,  G01N27/49 ,  G01N2201/06113 ,  C12Q2565/631

    摘要： Optoelectronic control of solid-state nanopores and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. Methods for controlling the translocation speed of biopolymers through solid-state nanopores and methods for unblocking clogged pores by illuminating nanopores are described.

    摘要翻译： 固态纳米孔的光电子控制及其应用。 纳米孔是非常敏感的单分子传感器。 电子束已被用于制备具有亚纳米分辨率的薄固态膜中的合成纳米孔。 描述了通过固态纳米孔控制生物聚合物的转运速度的方法以及通过照射纳米孔解除堵塞的孔的方法。

    [1,3] DIOXOLO [4,5-G] QUINOLINE-6(5H)THIONE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER
    95.
    发明申请
    [1,3] DIOXOLO [4,5-G] QUINOLINE-6(5H)THIONE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER 有权
    [1,3] DIOXOLO [4,5-G]喹啉-6（5H）衍生物作为用于治疗癌症的最新SV40因子（LSF）的抑制剂

    公开(公告)号：US20150344491A1

    公开(公告)日：2015-12-03

    申请号：US14737600

    申请日：2015-06-12

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： Scott E. SCHAUS ,  Ulla HANSEN ,  Joshua A. BISHOP

    IPC分类号： C07D491/056

    CPC分类号： C07D491/056 ,  C07D491/147

    摘要： The present invention relates generally to methods, compounds and/or compositions suitable for inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.

    摘要翻译： 本发明一般涉及适于抑制，预防和/或治疗癌症的方法，化合物和/或组合物，例如， 肝细胞癌（HCC）。 在一些实施方案中，本发明涉及小分子化合物用于抑制，预防和/或治疗转录因子晚期SV40因子（LSF）用于治疗HCC或其它癌症类型的表达的用途。

    High-power fiber laser employing nonlinear wave mixing with higher-order modes
    96.
    发明授权
    High-power fiber laser employing nonlinear wave mixing with higher-order modes 有权
    高功率光纤激光器采用高阶模式的非线性波混频

    公开(公告)号：US09203209B2

    公开(公告)日：2015-12-01

    申请号：US14529637

    申请日：2014-10-31

    申请人： Trustees of Boston University

    发明人： Siddharth Ramachandran

    IPC分类号： G02F1/35 ,  H01S3/30 ,  G02B6/02 ,  H01S3/108 ,  H01S3/00 ,  H01S3/067 ,  H01S3/16 ,  H01S3/23

    CPC分类号： H01S3/108 ,  G02B6/02023 ,  G02F1/3536 ,  H01S3/0092 ,  H01S3/06708 ,  H01S3/06725 ,  H01S3/1618 ,  H01S3/2391

    摘要： A high-power fiber laser exploits efficiency and wavelength-conversion of nonlinear wave mixing in a higher-order mode (HOM) fiber providing large effective area and higher-power operation than single-order mode (SMF) fiber. In a “monomode” approach, mixing waves (pump(s), signal, idler) propagate in the same higher-order mode, and in an “intermodal” approach different waves propagate in different modes. The monomode approach can provide high-power wavelength conversion generating output in a desired band where good dopants may be unavailable. The intermodal approach demonstrates coherent combining of outputs of multiple lasers to generate high-power output in a desired band.

    摘要翻译： 高功率光纤激光器在高阶模（HOM）光纤中利用非线性波混频的效率和波长转换，提供比单模（SMF）光纤更大的有效面积和更高功率的操作。 在“单模”方法中，混合波（泵，信号，空载）以相同的高阶模式传播，并且在“联运”方式中，不同的波以不同的模式传播。 单模方法可以在可能不可用的良好掺杂剂的期望频带中提供高功率波长转换产生输出。 多模式方法显示了多个激光器的输出的相干组合，以在期望的频带内产生高功率输出。

    Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
    98.
    发明授权
    Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof 有权
    固态纳米孔和纳米孔阵列的化学官能化及其应用

    公开(公告)号：US09121843B2

    公开(公告)日：2015-09-01

    申请号：US12599440

    申请日：2008-05-08

    申请人： Amit Meller ,  Meni Wanunu

    发明人： Amit Meller ,  Meni Wanunu

    IPC分类号： G01N25/18 ,  G01N33/487 ,  B82Y15/00

    CPC分类号： G01N21/6428 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N33/48721 ,  G01N2021/6439 ,  Y10T428/2982 ,  Y10T436/143333 ,  C12Q2521/543 ,  C12Q2565/631

    摘要： Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

    摘要翻译： 固态纳米孔和纳米孔阵列的化学官能化及其应用。 纳米孔是非常敏感的单分子传感器。 最近，电子束已被用于制备具有亚纳米分辨率的薄固态膜中的合成纳米孔。 提供了一类新的化学改性的纳米孔传感器，它们通过以下方式提供了纳米孔单层涂层的两种方法：（1）从溶液中自组装，其中纳米孔径可达到-10nm直径可重复涂覆，以及（2）自组装电压 其中可以涂覆5nm纳米孔。 提供了化学修饰的纳米孔的应用，包括：检测生物聚合物如DNA和RNA; 固定酶或其他蛋白质进行检测或产生化学梯度; 和局部pH感测。