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公开(公告)号：US20160302295A1
公开(公告)日：2016-10-13
申请号：US14212787
申请日：2014-03-14
Inventor： Donald Umstadter
Abstract: A method for temporally and spatially aligning a laser-based x-ray source and maintaining alignment is disclosed. A pump laser beam, which interacts with a plasma source to create an electron beam, is aligned with the electron beam. A scattering laser beam is overlapped with the pump laser beam at an intersection point. The pump laser beam and scattering laser beam alignments are monitored and adjusted to maintain optimal alignment during operation of the laser-based x-ray source.
Abstract translation: 公开了一种用于时间和空间上对准基于激光的x射线源并保持对准的方法。 与等离子体源相互作用以产生电子束的泵浦激光束与电子束对准。 散射激光束在交点处与泵浦激光束重叠。 监测和调整泵激光束和散射激光束对准以在基于激光的x射线源的操作期间保持最佳对准。
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92.发明授权Compositions and methods for the treatment of juvenile neuronal ceroid lipofuscinosis and related disorders 有权用于治疗青少年神经元类脂质脂褐质激素和相关疾病的组合物和方法公开(公告)号：US09457030B2
公开(公告)日：2016-10-04
申请号：US14066506
申请日：2013-10-29
Inventor： Tammy Kielian
IPC: A61K31/522 , A61K31/4545 , A61K31/4015 , A61K31/44 , A61K31/4425 , A61K45/06 , A61K38/17
CPC classification number: A61K31/4425 , A61K31/4015 , A61K31/44 , A61K31/4545 , A61K31/522 , A61K38/17 , A61K38/177 , A61K45/06 , A61K2300/00
Abstract: Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both.
Abstract translation: 提供了用于预防和治疗少年神经元细胞脂褐色素沉积的材料和方法，包括施用有效量的半通道抑制剂或磷酸二酯酶-4抑制剂中的至少一种。 在一些实施方案中，所述方法包括施用有效量的每种半通道抑制剂和磷酸二酯酶-4抑制剂。 还提供了包含半通道抑制剂或磷酸二酯酶-4抑制剂的药物组合物，以及包含至少一种有效剂量的半通道抑制剂或磷酸二酯酶-4抑制剂或两者的组合的试剂盒。
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93.发明申请公开(公告)号：US20160222407A1
公开(公告)日：2016-08-04
申请号：US14971366
申请日：2015-12-16
Inventor： Blair D. Siegfried , Kenneth E. Narva , Kanika Arora , Sarah E. Worden , Chitvan Khajuria , Elane Fishilevich , Nicholas P. Storer , Meghan Frey , Ronda L. Hamm , Ana M. Velez
IPC: C12N15/82 , A01N57/16 , C12N15/113
CPC classification number: C12N15/8286 , A01N57/16 , C12N15/113 , C12N15/8218 , C12N2310/14 , Y02A40/162
Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
Abstract translation: 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。
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公开(公告)号：US09391287B1
公开(公告)日：2016-07-12
申请号：US14576878
申请日：2014-12-19
Inventor： Jinsong Huang , Qingfeng Dong , Rui Dong , Yuchuan Sao , Cheng Bi , Qi Wang , Zhengguo Xiao
CPC classification number: H01L51/4213 , H01L51/0003 , H01L51/0037 , H01L51/0047 , H01L51/0094 , H01L51/424 , H01L2251/308 , Y02E10/549
Abstract: A semiconductor device and a method for fabrication of the semiconductor device are described that include a perovskite layer formed using a solution process with lead iodine and methylammonium halide. In an implementation, a semiconductor device that employs example techniques in accordance with the present disclosure includes a cathode layer; an anode layer; and an active layer disposed between the cathode layer and the anode layer, where the active layer includes a perovskite layer including an interdiffused and annealed lead iodine (PbI2) film and methylammonium halide (CH3NH3X) film. In implementations, a process for fabricating a continuous-perovskite semiconductor device that employs example techniques in accordance with the present disclosure includes spinning a PbI2 layer onto an ITO-covered glass; spinning an MAI layer onto the PbI2 layer; annealing the PbI2 layer and the MAI layer; spinning a PCBM layer onto a resulting perovskite layer; and depositing an Al layer.
Abstract translation: 描述了半导体器件和半导体器件的制造方法，其包括使用铅碘和甲基卤化铵的溶液法形成的钙钛矿层。 在一个实现中，采用根据本公开的示例技术的半导体器件包括阴极层; 阳极层; 以及设置在阴极层和阳极层之间的有源层，其中活性层包括包含相互扩散和退火的铅碘（PbI 2）膜和甲基卤化铵（CH 3 NH 3 X）膜的钙钛矿层。 在实现中，根据本公开的采用示例技术的连续钙钛矿半导体器件的制造方法包括将PbI 2层旋转到ITO覆盖的玻璃上; 将MAI层旋转到PbI2层上; 退火PbI2层和MAI层; 将PCBM层旋转到所得的钙钛矿层上; 并沉积Al层。
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公开(公告)号：US09353094B2
公开(公告)日：2016-05-31
申请号：US14639501
申请日：2015-03-05
Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： Amarnath Natarajan , Qianyi Chen , Vashti C. Bryant , Rajkumar Rajule
IPC: C07D241/44 , C07D409/14 , C07D241/42 , C07D405/04 , C07D405/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
CPC classification number: C07D409/14 , C07D241/42 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D471/04
Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.
Abstract translation: 本文公开了式（I）的化合物和抑制IKK和bgr的方法; 和NF-κB信号通路和mTOR通路。
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Patent Agency Ranking
96.发明申请Robotic Device with Compact Joint Design and Related Systems and Methods 审中-公开具有紧凑接头设计及相关系统和方法的机器人装置公开(公告)号：US20160135898A1
公开(公告)日：2016-05-19
申请号：US14938667
申请日：2015-11-11
Inventor： Tom Frederick , Eric Markvicka , Shane Farritor , Dmitry Oleynikov
CPC classification number: A61B34/30 , A61B18/082 , A61B18/14 , A61B18/1445 , A61B2017/00398 , A61B2017/00407 , A61B2017/00477 , A61B2018/00595 , A61B2018/1253 , A61B2018/1422 , A61B2034/305 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61B2218/007 , B25J9/0087 , B25J9/046 , B25J9/102
Abstract: The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.
Abstract translation: 本文公开的实施例涉及具有紧凑关节构造的各种机器人和/或体内医疗装置。 其他实施例涉及可并入某些机器人和/或体内医疗装置中的各种医疗装置部件，包括具有抓紧器或烧焦端部执行器的前臂。
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97.发明申请公开(公告)号：US20150359862A1
公开(公告)日：2015-12-17
申请号：US14763360
申请日：2014-01-30
Inventor： Keshore R. Bidasee
IPC: A61K38/51
CPC classification number: A61K38/51 , A61K48/00 , C12N9/88 , C12Y404/01005
Abstract: Compositions and methods for inhibiting diabetes-related complications are provided.
Abstract translation: 提供了抑制糖尿病相关并发症的组合物和方法。
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公开(公告)号：US20150306181A1
公开(公告)日：2015-10-29
申请号：US14376969
申请日：2013-02-06
Applicant: Board of Regents of the University of Nebraska , University of Washington Through Its Center for Commercialization
Inventor： Xiang Yi , Alexander V. Kabanov , William Banks
CPC classification number: A61K38/2264 , A61K9/0043 , A61K38/22 , A61K47/59 , A61K47/593 , A61K47/60
Abstract: Compositions and methods for delivering therapeutic compounds to the brain are provided.
Abstract translation: 提供了将治疗化合物递送至脑的组合物和方法。
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公开(公告)号：US20150306051A1
公开(公告)日：2015-10-29
申请号：US14629532
申请日：2015-02-24
Inventor： Donald W. Miller , Jonathan L. Vennerstrom , Mark C. Faulkner
IPC: A61K31/185 , A23L2/52 , A23K1/16 , A23L1/305
CPC classification number: A61K31/198 , A23K20/10 , A23K20/105 , A23K20/142 , A23K50/10 , A23L2/52 , A23L33/10 , A23L33/175 , A23P10/40 , A23V2002/00 , A61K9/0053 , A61K31/185 , A61K31/195 , A61K31/661 , A23V2250/306 , A23V2200/33 , A23V2200/316
Abstract: The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
Abstract translation: 本发明涉及第三代肌酸，特别是肌酸盐酸盐，其由于其增强的生物可利用性而促进肌肉发育和恢复的显着改善，同时与以前的肌酸形式相比，引起较少的负面副作用。
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公开(公告)号：US20150297587A1
公开(公告)日：2015-10-22
申请号：US14648404
申请日：2013-11-30
Inventor： Harris A. Gelbard , Stephen Dewhurst , Howard E. Gendelman
IPC: A61K31/496 , A61K9/48 , A61K45/06 , A61K31/4418 , A61K31/427
CPC classification number: A61K31/496 , A61K9/4866 , A61K31/427 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/506 , A61K31/536 , A61K31/553 , A61K45/06 , A61K2300/00
Abstract: Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed.
Abstract translation: 公开了用于治疗感染了逆转录病毒的个体的方法，其包括向个体有效量施用混合谱系激酶抑制剂和抗逆转录病毒药物。 在另外的方面，公开了用于治疗感染了逆转录病毒的个体的方法，其包括施用配制成包含表面活性剂的结晶纳米颗粒和MLK抑制剂的抗逆转录病毒药物。 还进一步公开的是用于治疗感染了逆转录病毒的个体的方法，其包括施用包含配制成包含表面活性剂的结晶纳米颗粒的抗逆转录病毒和MLK抑制剂的组合物。 还进一步公开的是包含抗逆转录病毒药物，MLK抑制剂和表面活性剂的组合物，其中所述组合物是结晶纳米颗粒。 还公开了包含MLK抑制剂与纳米颗粒形式的其它药物的组合物及其使用方法。
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