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公开(公告)号：US10314946B2
公开(公告)日：2019-06-11
申请号：US15890504
申请日：2018-02-07
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob Klein , Ronit Goldberg , Noa Iuster , Raya Sorkin
Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
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公开(公告)号：US10294482B2
公开(公告)日：2019-05-21
申请号：US15312734
申请日：2015-05-21
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ron Milo , Niv Antonovsky , Elad Noor , Arren Bar-Even , Yehudit Zohar , Lior Zelcbuch , Shmuel Gleizer , Shira Amram
IPC: C12N15/70 , C12N15/52 , C12N15/74 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90
Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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公开(公告)号：US10281459B2
公开(公告)日：2019-05-07
申请号：US14754785
申请日：2015-06-30
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Zohar Pode
IPC: C07K7/06 , G01N33/58 , G01N33/53 , C07D417/06 , C07D417/14 , C07F9/6541 , G01N33/574 , G01N33/573 , C09K11/06
Abstract: The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
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公开(公告)号：US20190091266A1
公开(公告)日：2019-03-28
申请号：US16198811
申请日：2018-11-22
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Yair Reisner , Carmit Hillel-Karniel , Chava Rosen , Esther Bachar-Lustig , Elias Shezen
Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.
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公开(公告)号：US20190048330A1
公开(公告)日：2019-02-14
申请号：US16108402
申请日：2018-08-22
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph Aharoni , Samuel Bocobza , Tal Dahan , Avraham A. Levy
IPC: C12N9/22 , C12N15/62 , C12N15/113 , C07K14/08 , C12N15/82
Abstract: Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.
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Patent Agency Ranking
公开(公告)号：US20190031733A1
公开(公告)日：2019-01-31
申请号：US16055241
申请日：2018-08-06
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rachel Lea EISENBACH , Yosi GOZLAN , Esther TZEHOVAL
IPC: C07K14/705 , A61K35/17 , C12N15/10 , C07K14/725
Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
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公开(公告)号：US20190026502A1
公开(公告)日：2019-01-24
申请号：US16070679
申请日：2017-01-19
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Gil SEGEV , Ido SHAHAF , Gilad ASHAROV , Moni NAOR
CPC classification number: G06F21/79 , G06F12/1408 , G06F16/00 , G06F16/245 , G06F21/602 , G06F21/6227 , G06F2212/1052 , H04L9/0861
Abstract: A method for searchable symmetric encryption. The method includes: accessing a computerized database that comprises keyword lists, each of the keyword lists comprising memory addresses of electronic documents that all contain a respective keyword; binning the memory addresses by performing balanced allocation of the memory addresses into ordered bins, such that at least some of the ordered bins each contains memory addresses of electronic documents that contain different keywords; encrypting each of the memory addresses with an encryption key that is derived from the keyword of the respective memory address; and storing the ordered bins at consecutive locations in a non-transient computer-readable memory, wherein the consecutive locations preserve the order of the ordered bins.
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公开(公告)号：US20190022152A1
公开(公告)日：2019-01-24
申请号：US16151455
申请日：2018-10-04
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Eran ELINAV , Eran SEGAL
IPC: A61K35/741 , C12Q1/6883 , C12Q1/04 , C12Q1/02
Abstract: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.
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99.发明申请公开(公告)号：US20190015441A1
公开(公告)日：2019-01-17
申请号：US16068172
申请日：2017-01-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Idit SHACHAR , Hadas LEWINSKY , Lihi RADOMIR , Anna WIENER
IPC: A61K31/713 , A61K38/17 , A61P29/00 , A61P35/02 , A61P37/06
CPC classification number: A61K31/713 , A61K38/1774 , A61K2039/505 , A61P29/00 , A61P35/02 , A61P37/06 , C07K16/2896 , C07K2317/76
Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.
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公开(公告)号：US10159724B2
公开(公告)日：2018-12-25
申请号：US15286327
申请日：2016-10-05
Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , UNIVERSITAET DUISBURG-ESSEN
Inventor： Edward H. Schuchman , Erich Gulbins , Anthony Futerman , Yael Pewzner-Jung
Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
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