摘要:
The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要:
A method for performing automated telemarketing comprising receiving potential customer data including a telephone number. A telephone call is initiated to the telephone number using an auto-dialing device. Notification is received at a voice platform that the potential customer has answered the telephone call. The voice platform includes a text-to-speech device and a speech recognition device. In response to receiving the notification, a verbal greeting is sent to the potential customer. The greeting is provided by the text-to-speech device. The method further comprises conversing with the potential customer via the voice platform in response to sending the verbal greeting. The conversing includes receiving a message from the potential customer via the speech recognition device. Information is provided to the potential customer responsive to the message. The telephone call is ended responsive to the conversing and telephone call data is transmitted to a database in response to the telephone call ending.
摘要:
A method and system for notifying a user that the user is engaging in interstitial communication. An intermediation system within an HTTP communication path between a content server and a client station engages in interstitial communication with a client station. During the interstitial communication, the intermediation system sends one or more interstitial screens to the client station and includes in each screen a predefined interstitial notice. Further, to help safeguard against the possibility that a third party will try to provide the interstitial notice within an HTTP response to the client station, the intermediation system can be arranged to detect and strip the interstitial notice from any such HTTP response.
摘要:
An information retrieval system is described that dynamically prioritizes search request results prior to output to a user. When a database search yields multiple hits, the results are first categorized into a series of groups. Categories are determined from any number of different factors, such as geographical locations of the search results, amenities, hours of operation, etc. For each category, the search results can be parsed into groups within the category. The results are first reported to the user in general terms, as a number of search results in each of the groups. The user is prompted to select the group that is of most interest, and the portion of the individual search results that are within the selected group are reported.
摘要:
A compound of Formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is NR.sub.1 ; R.sub.1 is H, C.sub.1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i --Het; R.sub.2 is H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are independently H or halo; R.sub.5 is H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy; m and n taken together are 1 or 2. The compounds are useful antimicrobial agents.
摘要:
A system for laying out a capacitor array (400) implements a programmable capacitor (33-39) whose operation is controlled with a binary control word. A programmable capacitance is produced by coupling binary weighted, switchable capacitors (101-107) between terminals (51, 52) of the programmable capacitor. The capacitor array includes two or more unit capacitors (101, 103) of unequal areas. The other capacitors in the array are derived by interconnecting multiple capacitors that match one of the unit capacitors. Die area is reduced while accuracy is maintained by controlling the larger unit capacitor with the least significant bit of the binary control word whenever possible and using the smaller unit capacitor only as a trim capacitor.
摘要:
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical division. Lineage restriction is demonstrated within developing clones which are sensitive to the local environment. The invention also includes such cells which are transfected with foreign nucleic acid, e.g., to produce an immortalized neural stem cell, and immortalized cell lines which are capable of subsequent disimmortalization. The invention further includes transplantation assays which allow for the identification of mammalian multipotent neural stem cells from various tissues and methods for transplanting mammalian neural stem cells and/or neural or glial progenitors into mammals. A novel method for detecting antibodies to neural cell surface markers is disclosed as well as a monoclonal antibody to mouse LNGFR.
摘要:
The invention includes methods for the isolation and clonal propagation of mammalian neural stem cells. The methods employ a novel separation and culturing regimen and bioassays for establishing the generation of neural stem cell derivatives. These methods result in the production of non-transformed neural stem cells and their progeny. The invention demonstrates, at the clonal level, the self regeneration and asymmetrical division of mammalian neural stem cells for the first time in feeder cell-independent cultures. Lineage restriction is demonstrated within a developing clone and is shown to be sensitive to the local environment. Multipotent neural stem cells cultured on a mixed substrate of poly-D-lysine and fibronectin generate PNS neurons and glia, but on fibronectin alone the stem cells generate PNS glia but not neurons. The neurogenic potential of the stem cells, while not expressed, is maintained over time on fibronectin. The invention further includes transplantation assays which allow for the identification of mammalian neural stem cells from various tissues. It also includes methods for transplanting mammalian neural stem cells and/or neural or glial progenitors into mammals.
摘要:
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical division. Lineage restriction is demonstrated within developing clones which are sensitive to the local environment. The invention also includes such cells which are transfected with foreign nucleic acid, e.g., to produce an immortalized neural stem cell. The invention further includes transplantation assays which allow for the identification of mammalian multipotent neural stem cells from various tissues and methods for transplanting mammalian neural stem cells and/or neural or glial progenitors into mammals. A novel method for detecting antibodies to neural cell surface markers is disclosed as well as a monoclonal antibody to mouse LNGFR.