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公开(公告)号：US20190388460A1
公开(公告)日：2019-12-26
申请号：US16013499
申请日：2018-06-20
IPC分类号： A61K31/765
摘要： Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
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公开(公告)号：US20190174757A1
公开(公告)日：2019-06-13
申请号：US15839199
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
IPC分类号： A01N37/30 , C07D233/61 , A01N43/50 , C07C233/78 , C07C231/12
CPC分类号： A01N37/30 , A01N33/12 , A01N43/50 , C07C231/12 , C07C233/78 , C07D233/61 , A01N25/10
摘要： Techniques regarding ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments can comprise a monomer, which can comprise a single ionene unit. The single ionene unit can comprise a cation distributed along a molecular backbone. Also, a hydrophobic functional group can be covalently bonded to the molecular backbone, and the single ionene unit can have antimicrobial functionality.
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公开(公告)号：US20190174754A1
公开(公告)日：2019-06-13
申请号：US15839415
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
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公开(公告)号：US20190048208A1
公开(公告)日：2019-02-14
申请号：US15671693
申请日：2017-08-08
发明人： Amos Cahan , Xin Ding , Mareva B. Fevre , James L. Hedrick , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , C09D161/22 , A01N33/08 , A01N31/16 , C09D181/02 , A01N33/10 , B05D1/02 , B05D1/00 , B29C39/38 , B29C39/26
摘要： Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
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95.发明授权公开(公告)号：US10183099B2
公开(公告)日：2019-01-22
申请号：US14047056
申请日：2013-10-07
发明人： Xin Ding , James L. Hedrick , Chuan Yang , Yi Yan Yang
摘要： Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.
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公开(公告)号：US10023697B2
公开(公告)日：2018-07-17
申请号：US15361313
申请日：2016-11-25
发明人： Gregory Breyta , Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , Wei Han , James L. Hedrick , Alshakim Nelson , Robert J. Ono , Yi Yan Yang , Mu San Zhang
IPC分类号： C08G73/06 , C08G69/48 , C08G73/02 , A01N43/60 , A01N37/44 , A61K8/88 , A61K31/785 , A61K31/787 , A61Q5/02 , A61Q11/00 , A61Q15/00 , C11D3/48 , D21H17/55 , A61Q17/00 , C11D3/37 , A01N43/40 , A01N37/18 , A61K8/86 , A61Q19/00 , A01N37/12 , A01N37/20 , A01N43/58 , A01N47/06 , A61K8/84 , A61K8/85 , C08G63/91 , C08G64/42 , A61K45/06 , D21H17/56 , D21H21/36 , C08L79/02 , C08L77/04
CPC分类号： C08G69/48 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/44 , A01N43/40 , A01N43/58 , A01N43/60 , A01N47/06 , A61K8/84 , A61K8/85 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61K45/06 , A61K2800/10 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q19/007 , C08G63/916 , C08G64/42 , C08G73/0206 , C08G73/024 , C08G73/0273 , C08G73/028 , C08G73/0293 , C08G73/0633 , C08G2650/02 , C08G2650/38 , C08G2650/58 , C08L77/04 , C08L79/02 , C11D3/3723 , C11D3/48 , D21H17/55 , D21H17/56 , D21H21/36 , A61K2300/00
摘要： A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
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公开(公告)号：US20170319704A1
公开(公告)日：2017-11-09
申请号：US15145020
申请日：2016-05-03
发明人： Willy Chin , Yukti Choudhury , Shujun Gao , James L. Hedrick , Xiyu Ke , Min-Han Tan , Jye Yng Teo , Yi Yan Yang
IPC分类号： A61K47/60 , C08G63/42 , A61K9/00 , A61K47/58 , C08G64/18 , C08G64/02 , C08G63/78 , A61K31/704
CPC分类号： A61K47/60 , A61K9/0019 , A61K9/1075 , A61K31/704 , A61K47/58 , C08G63/42 , C08G63/78 , C08G64/02 , C08G64/025 , C08G64/183
摘要： Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (
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公开(公告)号：US20170281662A1
公开(公告)日：2017-10-05
申请号：US15627607
申请日：2017-06-20
申请人： International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del PaÌs Vasco/Euskal Herriko Unibertsitatea
发明人： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A61K31/704 , A61K31/713 , A61K9/51
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
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公开(公告)号：US09717797B2
公开(公告)日：2017-08-01
申请号：US14097488
申请日：2013-12-05
申请人： International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
发明人： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Victor W. L. Ng , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A61K9/00 , A61K47/34 , A61K31/704 , A61K31/713 , A61K9/51 , C08G64/02 , C08G64/18 , A61K38/16 , A61K38/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
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公开(公告)号：US09637592B2
公开(公告)日：2017-05-02
申请号：US15343537
申请日：2016-11-04
CPC分类号： C08G64/183 , A61K9/0024 , A61K9/06 , A61K31/355 , A61K31/592 , A61K31/593 , A61K47/34 , A61K47/551 , A61K47/60 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C08G65/3318 , C08G2210/00 , Y02A50/473
摘要： Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
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