公开(公告)号：US20190066991A1

公开(公告)日：2019-02-28

申请号：US16101647

申请日：2018-08-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Alan Keith Jarmusch ,  Valentina Pirro

IPC: H01J49/04 ,  A61B5/145 ,  A61B5/00 ,  A61B10/02 ,  A61F13/38 ,  H01J49/16

Abstract: The invention generally relates to systems and methods for sample analysis using swabs. In certain aspects, the invention provides systems that include a probe having a conductive proximal portion coupled to a porous material at a distal portion of the probe that is configured to retain a portion of a sample that has contacted the porous material, and a mass spectrometer having an inlet. The system is configured such that the porous material at a distal portion of the probe is aligned over the inlet of the mass spectrometer.

公开(公告)号：US20190066989A1

公开(公告)日：2019-02-28

申请号：US15772738

申请日：2016-11-02

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Christopher Pulliam

IPC: H01J49/00 ,  H01J49/42

Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.

公开(公告)号：US10213143B2

公开(公告)日：2019-02-26

申请号：US15989706

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  G01N33/483 ,  H01J49/34 ,  A61M11/00 ,  A61M25/00 ,  H01J49/04 ,  H01J49/16 ,  A61B10/00 ,  A61B5/15 ,  G01N1/02 ,  A61B5/157 ,  A61B5/145

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20190043706A1

公开(公告)日：2019-02-07

申请号：US16073993

申请日：2017-04-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/42 ,  H01J49/00

Abstract: The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap.

公开(公告)号：US10197547B2

公开(公告)日：2019-02-05

申请号：US15677231

申请日：2017-08-15

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Fred Paul Mark Jjunju ,  Anyin Li ,  Iman S. Roqan

IPC: H01J49/10 ,  H01J49/00 ,  G01N33/28 ,  G01N30/72 ,  H01J49/16 ,  H01J49/04

Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

公开(公告)号：US10168312B2

公开(公告)日：2019-01-01

申请号：US15649763

申请日：2017-07-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Christina Ramires Ferreira ,  Tiago Sobreira

IPC: H01J49/42 ,  G01N33/48 ,  G01N33/487 ,  G06F17/30 ,  H01J49/00 ,  H01J49/16 ,  H04L1/00 ,  G06F19/00

Abstract: The invention generally relates to systems methods for screening a sample based on multiple reaction monitoring mass spectrometry. In certain embodiments, the invention provides methods for screening a sample that involve ionizing a sample. Mass spectrometry is then used in order to monitor specific transitions connecting one or more ion pairs within the sample in order to generate a multidimensional chemical profile of the sample. Then, the multidimensional chemical profile of the sample is compared to a database of reference multidimensional chemical profiles, thereby screening the sample. Each reference multidimensional chemical profile is produced from a training set of data.

公开(公告)号：US20180275118A1

公开(公告)日：2018-09-27

申请号：US15762597

申请日：2016-09-24

Applicant: Purdue Research Foundation

Inventor： Baird Zane ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

IPC: G01N33/53

CPC classification number: G01N33/5302 ,  G01N2458/15

Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

公开(公告)号：US20180114686A1

公开(公告)日：2018-04-26

申请号：US15789688

申请日：2017-10-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/422 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/429

Abstract: The invention generally relates to ion traps that operate by applying an inverse Mathieu q scan. In certain embodiments, the invention provides systems that include a mass spectrometer having an ion trap and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply an inverse Mathieu q scan to the ion trap.

公开(公告)号：US20180043327A1

公开(公告)日：2018-02-15

申请号：US15673658

申请日：2017-08-10

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  David Logsdon

IPC: B01J19/24 ,  B01D5/00 ,  B01J19/26 ,  B01D19/00 ,  B01J14/00 ,  B01J19/08

CPC classification number: B01J19/2465 ,  B01D5/0069 ,  B01D19/0031 ,  B01J4/002 ,  B01J14/00 ,  B01J19/087 ,  B01J19/26 ,  B01J2219/00087 ,  B01J2219/00099 ,  B01J2219/0803 ,  B01J2219/0884 ,  B05B5/025 ,  B05B5/03 ,  H01J49/26

Abstract: The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.

公开(公告)号：US09797872B2

公开(公告)日：2017-10-24

申请号：US15359031

申请日：2016-11-22

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Ryan Espy

IPC: H01J49/00 ,  G01N30/95 ,  G01N30/91 ,  G01N33/49

CPC classification number: G01N30/95 ,  G01N30/91 ,  G01N33/49 ,  H01J49/0031 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/167 ,  H01J49/168

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.