公开(公告)号：US11802796B2

公开(公告)日：2023-10-31

申请号：US17643157

申请日：2021-12-07

Applicant: California Institute of Technology

Inventor： Seyedeh Sona Hosseini

IPC: G01J3/45 ,  G01J3/02 ,  G01J3/18 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/021 ,  G01J3/0202 ,  G01J3/18 ,  G01J3/4531

Abstract: Novel monolithic reflective spatial heterodyne spectrometers (SHS) interferometer systems are presented. Monolithic systems in accordance with the invention have a single supporting structure wherein input optics, output optics, a flat mirror, a roof mirror, and a symmetric grating are affixed. Embodiments of the invention contain only fixed parts, and the optics do not move in relation to the supporting structure. Embodiments of the present invention enables smaller, lighter, and more robust reflective SHS systems as compared to conventional interferometry. Additionally, embodiments of the present invention require less time and skill for construction and maintenance, and is a better economic option. Additional embodiments can include multiple interferometer systems in a single supporting structure.

公开(公告)号：US20230337906A1

公开(公告)日：2023-10-26

申请号：US18344118

申请日：2023-06-29

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Mark S. Humayun

IPC: A61B3/10 ,  G01N30/02 ,  G01G19/00 ,  G01F22/00 ,  G01N1/10 ,  A61B5/00 ,  A61B10/00 ,  G01N33/487

CPC classification number: A61B3/101 ,  G01N30/02 ,  G01G19/00 ,  G01F22/00 ,  G01N1/10 ,  A61B5/6821 ,  A61B10/0045 ,  A61B5/6867 ,  G01N33/4875 ,  A61B2010/0067 ,  G01N2030/027

Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

公开(公告)号：US11799704B2

公开(公告)日：2023-10-24

申请号：US17662213

申请日：2022-05-05

Applicant: California Institute of Technology ,  The Regents of the University of California ,  Technische Universität Berlin

Inventor： Philipp Walk ,  Babak Hassibi ,  Peter Jung ,  Hamid Jafarkhani

IPC: H04L27/26 ,  H04B7/0452 ,  H04L7/04 ,  H04B1/04 ,  H04L27/12

CPC classification number: H04L27/2602 ,  H04B1/0475 ,  H04B7/0452 ,  H04L7/042 ,  H04L7/048 ,  H04L27/122

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

公开(公告)号：US11795448B2

公开(公告)日：2023-10-24

申请号：US17473832

申请日：2021-09-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem Ismagilov ,  Erik Jue ,  Daan Witters

IPC: C12N15/10 ,  B01L3/00 ,  B01L7/00 ,  G01N21/64 ,  C12Q1/6806

CPC classification number: C12N15/1003 ,  B01L3/508 ,  B01L3/50851 ,  B01L3/502753 ,  B01L7/52 ,  C12N15/1006 ,  C12N15/1013 ,  C12Q1/6806 ,  G01N21/6428 ,  G01N21/6456 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2300/04 ,  B01L2300/069 ,  B01L2300/0672 ,  B01L2300/18 ,  B01L2400/0605

Abstract: A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

公开(公告)号：US20230332214A1

公开(公告)日：2023-10-19

申请号：US18074369

申请日：2022-12-02

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Long CAI ,  Carsten H. TISCHBIREK

IPC: C12Q1/6841 ,  G01N33/58

CPC classification number: C12Q1/6841 ,  G01N33/58

Abstract: This disclosure herein sets forth embodiments for a method for mapping the spatial distribution of one or more cellular components or cellular interactions by using barcodes to identify a cell or cellular component in the one or more cells, localizing, detecting, and mapping the spatial distribution of the one or more cellular components. The disclosure herein sets forth method to allow the mapping of spatial distributions of cellular components both intracellularly or intercellularly.

公开(公告)号：US11792381B2

公开(公告)日：2023-10-17

申请号：US16806691

申请日：2020-03-02

Applicant: California Institute of Technology

Inventor： Lihong Wang ,  Taewoo Kim ,  Jinyang Liang ,  Liren Zhu

IPC: H04N13/161 ,  H04N13/25 ,  H04N13/254 ,  H04N13/282 ,  G01S7/481 ,  G01S7/4865 ,  G01S17/894 ,  H04N23/72 ,  G02B5/04 ,  G01J11/00 ,  G01J9/00 ,  G02B21/10

CPC classification number: H04N13/161 ,  G01S7/4814 ,  G01S7/4865 ,  G01S17/894 ,  H04N13/25 ,  H04N13/254 ,  H04N13/282 ,  H04N23/72 ,  G01J9/00 ,  G01J2011/005 ,  G02B5/04 ,  G02B21/10

Abstract: Disclosed herein are systems and methods of phase-sensitive compressed ultrafast photography (pCUP). In some embodiments, a pCUP system comprises: a dark-field imaging system, and a compressed ultrafast photography (CUP system). The dark-field imaging system may comprise a laser source configured to illuminate the subject with a laser pulse; and a beam block configured to pass laser light scattered by the subject as a first series of phase images and block laser light not scattered by the subject. The CUP system may comprise: a spatial encoding module configured to receive the first series of phase images and to produce a second series of spatially encoded phase images; and a streak camera configured to receive the second series of spatially encoded phase images, to deflect each spatially encoded phase image by a temporal deflection distance, and to integrate the deflected phase images into a single raw CUP image.

公开(公告)号：US20230327774A1

公开(公告)日：2023-10-12

申请号：US18324433

申请日：2023-05-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dariush Divsalar ,  William H. Farr ,  Makan Mohageg ,  Samuel J. Dolinar ,  Matthew D. Thill

IPC: H04B10/50 ,  H04L25/49 ,  H04B10/54 ,  H04J14/00

CPC classification number: H04B10/503 ,  H04B10/54 ,  H04J14/005 ,  H04L25/4902

Abstract: Methods and devices implementing a combination of multi-dimensional pulse position modulation (PPM) with wavelength division multiplexing (WDM) or wavelength division multiplexing multiple access (WDMA) for long range space communications are disclosed. The described multi-dimensional PPM scheme can use the laser wavelength and/or polarization as the additional dimension(s) to the time dimension. Through examples it is shown that the disclosed teachings result in a higher photon information efficiency. Various exemplary embodiments are also presented to highlight the applications benefiting from the disclosed methods and devices.

公开(公告)号：US20230314605A1

公开(公告)日：2023-10-05

申请号：US18191949

申请日：2023-03-29

Applicant: California Institute of Technology

Inventor： Luis Costa ,  Alireza Marandi ,  Zhongwen Zhan

IPC: G01S17/02 ,  G01S17/89 ,  G01S7/481

CPC classification number: G01S17/02 ,  G01S17/89 ,  G01S7/4818

Abstract: A sensor system including an optical fiber comprising a first spatial channel and a second spatial channel, wherein the spatial channels are coupled and electromagnetic radiation propagates with different group velocities in each of the spatial channels. The sensor system further includes a source inputting the electromagnetic radiation into the first spatial channel at an input; and a detection system coupled to an output of the fiber, the detection system including a detector detecting transmission of the electromagnetic radiation coupled into the second spatial channel at different positions along the fiber between the input to the output, and generating a signal in response thereto; and a computer processing the signal to obtain a localized measurement of a physical parameter at one or more of the different positions along the fiber.

公开(公告)号：US11773475B2

公开(公告)日：2023-10-03

申请号：US17405836

申请日：2021-08-18

Applicant: California Institute of Technology

Inventor： Douglas C. Hofmann

IPC: C22C33/02 ,  B22F10/10 ,  C22C16/00 ,  B33Y80/00 ,  C22C38/02 ,  C22C38/00 ,  B23K26/00 ,  B23K26/342 ,  C22C38/12 ,  B33Y70/10 ,  B33Y40/10 ,  B22F10/14 ,  B22F10/25 ,  B22F10/28 ,  B22F10/38 ,  B22F10/66 ,  C22C1/04

CPC classification number: C22C33/0278 ,  B22F10/10 ,  B22F10/14 ,  B22F10/25 ,  B22F10/28 ,  B22F10/38 ,  B22F10/66 ,  B23K26/0093 ,  B23K26/342 ,  B33Y40/10 ,  B33Y70/10 ,  B33Y80/00 ,  C22C16/00 ,  C22C38/002 ,  C22C38/02 ,  C22C38/12 ,  B22F2301/205 ,  B22F2999/00 ,  C22C1/0458 ,  B22F2999/00 ,  B22F10/28 ,  B22F10/38 ,  C22C2200/02 ,  B22F2999/00 ,  B22F10/25 ,  B22F10/38 ,  C22C2200/02

Abstract: Methods and alloy systems for non-Be BMG matrix composite materials that can be used to additively manufacturing parts with superior mechanical properties, especially high toughness and strength, are provided. Alloys are directed to BMGMC materials comprising a high strength BMG matrix reinforced with properly scaled, soft, crystalline metal dendrite inclusions dispersed throughout the matrix in a sufficient concentration to resist fracture.

公开(公告)号：US11773116B2

公开(公告)日：2023-10-03

申请号：US17192129

申请日：2021-03-04

Applicant: California Institute Of Technology

Inventor： Anton A. Toutov ,  Kerry N. Betz ,  Andrew M. Romine ,  Robert H. Grubbs

IPC: C07F7/10

CPC classification number: C07F7/10

Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.