公开(公告)号：US09745621B2

公开(公告)日：2017-08-29

申请号：US15239155

申请日：2016-08-17

Applicant: WISYS Technology Foundation, Inc.

Inventor： Aric Martin Opdahl

IPC: G01N21/55 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/552 ,  G01N21/03 ,  G01N21/27 ,  G01N21/17

CPC classification number: C12Q1/6837 ,  C12Q1/6825 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/648 ,  G01N2021/1731 ,  G01N2201/1211

Abstract: A system and method for sensitive measurements of molecular binding as a function of time and temperature provided by a surface plasmon resonance (SPR) instrument producing a stable temperature gradient over the sensor surface. Continuous monitoring of reflected light intensity from different locations of the sensor allows simultaneous measurement of time and temperature dependence of binding interactions.

公开(公告)号：US09382554B2

公开(公告)日：2016-07-05

申请号：US13952071

申请日：2013-07-26

Applicant: Toivo Kallas ,  Matthew Nelson ,  Eric Singsaas

Inventor： Toivo Kallas ,  Matthew Nelson ,  Eric Singsaas

IPC: C12P5/02 ,  C12P5/00 ,  C12N9/88 ,  C12N9/90

CPC classification number: C12P5/007 ,  C12N9/88 ,  C12N9/90 ,  C12P5/002 ,  C12P5/026 ,  C12Y205/01001 ,  C12Y402/03015 ,  C12Y402/03027 ,  C12Y503/03002 ,  Y02P20/52

Abstract: Methods of isoprenoid production are provided by the present invention. In particular, transgenic Synechococcus sp. PCC 7002 cyanobacteria and methods for producing isoprene and pinene using a host transgenic Synechococcus sp. PCC 7002 cyanobacterium are provided.

Abstract translation: 异戊二烯生产方法由本发明提供。 特别是转基因聚球藻 PCC 7002蓝细菌和使用宿主转基因聚球藻生产异戊二烯和蒎烯的方法。 提供PCC 7002蓝藻。

公开(公告)号：US09381564B2

公开(公告)日：2016-07-05

申请号：US14453285

申请日：2014-08-06

Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

Inventor： Daniel S. McGuire ,  Eric E. Hellmstrom ,  Charles M. Olson

IPC: B22C1/10 ,  B22C9/04 ,  B22C9/10 ,  B22C1/22 ,  B22C1/26 ,  B22C9/02

CPC classification number: B22C1/10 ,  B22C1/22 ,  B22C1/26 ,  B22C9/02 ,  B22C9/04 ,  B22C9/10 ,  B33Y10/00 ,  B33Y80/00

Abstract: A printable refractory material is provided having a liquid and powder component configured for use in a 3-D powder printer, where the material forms hydraulic bonds when the liquid and powder components are combined. Methods of printing the refractory material and forming castings therefrom are also provided.

Abstract translation: 提供了一种可印刷耐火材料，其具有构造成用于3-D粉末打印机的液体和粉末组分，其中当液体和粉末组分组合时材料形成水力粘合。 还提供了打印耐火材料并由其形成铸件的方法。

公开(公告)号：US07703384B2

公开(公告)日：2010-04-27

申请号：US11738179

申请日：2007-04-20

Applicant: Jeffrey A. Annis ,  James Hubbard

Inventor： Jeffrey A. Annis ,  James Hubbard

IPC: A23L1/00

CPC classification number: F24C15/30

Abstract: A food transfer platform incorporating a stove unit elevates to different heights, by an extendible column, and can move along a floor.

Abstract translation: 包含炉子单元的食物转移平台通过可伸缩的柱升高到不同的高度，并且可以沿着地板移动。

公开(公告)号：US07618958B2

公开(公告)日：2009-11-17

申请号：US11173981

申请日：2005-06-30

Applicant: James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V. Srirama Sarma ,  Chunchun Zhang

Inventor： James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V. Srirama Sarma ,  Chunchun Zhang

IPC: A61P25/22 ,  A61K31/5513 ,  C07D243/14 ,  C07D243/18 ,  C07D487/04 ,  C07D495/04 ,  C07D495/14

CPC classification number: C07D243/24 ,  C07D243/16 ,  C07D471/06 ,  C07D487/04 ,  C07D487/06

Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

Abstract translation: 本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法， 效果。 本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-XXI中任一项所示的化学结构和药学上可接受的载体的化合物，前药或盐。

公开(公告)号：US20080108605A1

公开(公告)日：2008-05-08

申请号：US11929860

申请日：2007-10-30

Applicant: James Cook ,  Qi Huang ,  Xiaohui He ,  Xiaoyan Li ,  Jianming Yu ,  Dongmei Han

Inventor： James Cook ,  Qi Huang ,  Xiaohui He ,  Xiaoyan Li ,  Jianming Yu ,  Dongmei Han

IPC: A61K31/5517 ,  A61P25/22 ,  C07D243/14 ,  A61K31/5513 ,  C07D487/12

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

Abstract translation: 公开了口服活性苯二氮卓衍生物及其盐。 这些化合物及其盐具有抗焦虑和抗惊厥活性，降低镇静/催眠/肌肉松弛/共济失调作用。

公开(公告)号：US07119196B2

公开(公告)日：2006-10-10

申请号：US10402538

申请日：2003-03-28

Applicant: James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han ,  Snjezana Lelas ,  John F. McElroy

Inventor： James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han ,  Snjezana Lelas ,  John F. McElroy

IPC: C07D487/12

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

Abstract translation: 公开了口服活性苯二氮卓衍生物及其盐。 这些化合物及其盐具有抗焦虑和抗惊厥活性，降低镇静/催眠/肌肉松弛/共济失调作用。

公开(公告)号：US20060205760A1

公开(公告)日：2006-09-14

申请号：US10906956

申请日：2005-03-14

Applicant: Scott Hartsel ,  David Lewis

Inventor： Scott Hartsel ,  David Lewis

IPC: C12Q1/60 ,  G01N33/92 ,  C07D221/04 ,  A61K31/473

CPC classification number: C07D221/04 ,  C09B57/08 ,  G01N33/92

Abstract: The present invention provides molecules and methods for fluorescent microscopy and visualization of biomolecules, such as cholesterol. In a preferred embodiment, the present invention provides a compound having the structure: wherein R1 and R2 are selected from the group consisting of H, CnH2n+1, (CH2)mNH2, (CH2)mNH—SO2—R′, and CH2CH2OCH2CH2NH2 wherein n has a value between 4 and 18, wherein m has a value between 2 and 8, and wherein R′ is selected from the group consisting of CH3, C6H4, C6H4CH3, C6H4CO2H an its cyclic imide, C6H4Br, anthraquinon-2-yl, and 5-formyl-2-furyl, 2-carboxyphenyl.

Abstract translation: 本发明提供用于荧光显微镜和生物分子如胆固醇的可视化的分子和方法。 在优选的实施方案中，本发明提供具有以下结构的化合物：其中R 1和R 2选自H，C n， （CH 2）2 H 2n + 1，（CH 2）2 NH 2，（CH 2） NH 2 SO 2 -R'和CH 2 CH 2 CH 2 O（CH 3） 其中n具有在4和18之间的值，其中m具有在2和8之间的值，并且其中R'被选择 由CH 3，C 6 H 4，C 6 H 4，CH 3，CH 3， CH 3，CH 3，CO 2，C 2，C 6，C 6，C 6， H 4 Br，蒽醌-2-基和5-甲酰基-2-呋喃基，2-羧基苯基。

公开(公告)号：US06951741B2

公开(公告)日：2005-10-04

申请号：US10692889

申请日：2003-10-24

Applicant: Collins P. Mary Lynne ,  Yongjian S. Cheng

Inventor： Collins P. Mary Lynne ,  Yongjian S. Cheng

IPC: C12N1/21 ,  C12N15/74 ,  C12P21/02 ,  C12P21/00 ,  C12N15/63

CPC classification number: C12N15/74 ,  C12P21/02

Abstract: A method of expressing proteins is disclosed. In a preferable embodiment, the method comprises placing a DNA sequence encoding a protein or peptide and expression vector containing a regulatable promoter expressible in Rhodospirillum rubrum and expressing the protein within a bacterial host, wherein the host has extra capacity for membrane formation and wherein the host is a member of the genus Rhodospirillum.

Abstract translation: 公开了表达蛋白质的方法。 在优选的实施方案中，该方法包括放置编码蛋白质或肽的DNA序列和含有在红景天红链菌中可表达的可调节启动子并在细菌宿主中表达蛋白质的表达载体，其中所述宿主具有额外的膜形成能力，其中宿主 是Rhodospirillum属的成员。

公开(公告)号：US20050092459A1

公开(公告)日：2005-05-05

申请号：US10697378

申请日：2003-10-30

Applicant: Daniel McGuire

Inventor： Daniel McGuire

IPC: B22C1/02 ,  B22C9/04 ,  C08L20060101

CPC classification number: B22C1/183 ,  B22C1/02 ,  B22C1/181 ,  C04B35/18 ,  C04B35/481 ,  C04B35/62665 ,  C04B35/6316 ,  C04B35/634 ,  C04B35/6365 ,  C04B2235/3208 ,  C04B2235/3217 ,  C04B2235/3248 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/36 ,  C04B2235/3826 ,  C04B2235/5427 ,  C04B2235/5436

Abstract: A composition and method for forming investment casting shells includes using colloidal silica, zircon flour, and fused silica in a slurry which is applied to a pattern. After the slurry is applied to the pattern, it is allowed to partially or completely solidify. After the shell has solidified, the pattern may be melted or otherwise removed. A molten material is introduced into the shell and allowed to cool to form an article. Finally, the shell is broken away or otherwise removed from the article. The improved shell slurry composition and corresponding method minimizes pattern-to-pour cycle times and is environmentally friendly.

Abstract translation: 用于形成熔模铸造壳的组合物和方法包括在施加到图案的浆料中使用胶体二氧化硅，锆石粉和熔融二氧化硅。 在将浆料施加到图案之后，允许其部分或完全固化。 在外壳固化后，图案可能被熔化或以其他方式去除。 将熔融材料引入壳体中并使其冷却以形成制品。 最后，外壳被打破或从物品中移除。 改进的壳浆料组合物和相应的方法将模式到浇注循环时间最小化并且是环境友好的。