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124 条记录 (耗时 0.025 秒)

    Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
    92.
    发明授权
    Regeneration of living tissues by growth of isolated cells in porous implant and product thereof 失效
    在多孔植入物中分离细胞的生长及其产物再生生物组织

    公开(公告)号：US4553272A

    公开(公告)日：1985-11-19

    申请号：US238374

    申请日：1981-02-26

    申请人： Dana C. Mears

    发明人： Dana C. Mears

    IPC分类号： A61C8/00 ,  A61F2/00 ,  A61F2/30 ,  A61F2/46 ,  A61L27/38 ,  A61L27/56

    CPC分类号： A61F2/0063 ,  A61F2/30767 ,  A61L27/38 ,  A61L27/56 ,  A61C2008/0046 ,  A61C8/0036 ,  A61F2/0077 ,  A61F2002/0086 ,  A61F2002/30011 ,  A61F2002/30762 ,  A61F2002/30929 ,  A61F2002/3093 ,  A61F2002/4648 ,  A61F2250/0023

    摘要： A method of repair of patient tissues by implant including providing a living cell sample which is introduced into an implant member having a porous open structure. The cell sample may be cultured in the implant. The implant is secured to the patient, as by surgical implantation. In one embodiment, the implant portion which receives the cells preferably has a pore size of about 25 to 75 microns. In addition, a second pore size of about 100 to 400 microns for receipt of blood vessels and osteogenus cells through ingrowth after introduction into the patient, may be provided. The cell sample may advantageously be selected from the group consisting of cartilage cells, tendon cells, ligament cells and musculotendinous cells. The implant member may be advantageously used in bone or joint reconstruction surgery and in other forms such as artificial tooth implantation.A surgical implant comprising an inert member having, in one embodiment, a first series of open pores of an average size of about 25 to 75 microns and a second series of open pores of an average size of about 100 to 400 microns with patient cells growing within the pores.

    摘要翻译： 一种通过植入物修复患者组织的方法，包括提供活细胞样品，所述活细胞样品被引入到具有多孔开放结构的植入物构件中。 细胞样品可以在植入物中培养。 植入物通过手术植入固定到患者身上。 在一个实施例中，接收细胞的植入部分优选具有约25至75微米的孔径。 此外，可以提供约100至400微米的用于在引入患者之后通过向内生长接收血管和成骨细胞的第二孔径。 细胞样品可以有利地选自软骨细胞，肌腱细胞，韧带细胞和肌腱细胞。 植入物构件可有利地用于骨或关节重建手术以及其它形式，例如人造牙植入。 包括惰性构件的手术植入物，在一个实施方案中，其具有平均尺寸为约25至75微米的第一系列开放孔和平均尺寸为约100至400微米的第二系列开放孔，患者细胞生长 在毛孔内。

    Devices for Preparation of a Bone Graft and Methods of Use Thereof
    93.
    发明公开
    Devices for Preparation of a Bone Graft and Methods of Use Thereof 审中-公开

    公开(公告)号：US20240197498A1

    公开(公告)日：2024-06-20

    申请号：US18543480

    申请日：2023-12-18

    申请人： Stryker Corporation

    发明人： Jeremy Ming Graul ,  Kyle Craig Pilgeram

    IPC分类号： A61F2/46 ,  A61F2/30 ,  A61F2/40

    CPC分类号： A61F2/4644 ,  A61F2/30942 ,  A61F2/4081 ,  A61F2002/30955 ,  A61F2002/4648

    摘要： In an aspect, a clamp system is provided including a clamp and a base, the base including a graft-engaging block including a graft-engaging surface engaging a first surface of the graft, and the clamp contacts the graft while at least a portion of the graft opposite the first surface is removed. In another aspect, a method of preparing a distal radius bone graft is provided including positioning the distal radius bone graft into a clamp such that at least part of a proximal portion and at least another portion of the bone graft are accessible, performing a depth cut on the proximal portion of the graft to form a prepared proximal face, and performing a width cut on the another portion to form a prepared face.

    TISSUE GRAFTS AND METHODS OF MAKING AND USING THE SAME
    98.
    发明申请
    TISSUE GRAFTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    组织工艺及其制造和使用方法

    公开(公告)号：US20160324642A1

    公开(公告)日：2016-11-10

    申请号：US15108996

    申请日：2014-12-29

    申请人： THE NEW YORK STEM CELL FOUNDATION

    发明人： Giuseppe Maria de Peppo

    IPC分类号： A61F2/30 ,  A61L27/38 ,  C12N5/074 ,  A61F2/28

    CPC分类号： A61F2/30942 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30756 ,  A61F2002/2835 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30943 ,  A61F2002/30952 ,  A61F2002/4648 ,  A61K35/12 ,  A61L27/3821 ,  C12N5/0062 ,  C12N5/0607

    摘要： In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts. In some embodiments the tissue grafts are made using pluripotent stem cells, such as autologous pluripotent stem cells. In some embodiments, the tissue grafts are made by creating a digital model of a tissue portion to be replaced or repaired, such as a bone defect, partitioning the model into two or more model segments, and then producing tissue graft segments having a size and shape corresponding to that of the model segments. Such tissue graft segments may be assembled to form a tissue graft having a size and shape corresponding to that of the tissue portion to be replaced or repaired.

    摘要翻译： 在一些实施方案中，本发明提供组织移植物，例如血管化骨移植物，以及用于制备和使用这种组织移植物的方法。 在一些实施方案中，使用多能干细胞（例如自体多能干细胞）制备组织移植物。 在一些实施例中，组织移植物通过产生待更换或修复的组织部分的数字模型（例如骨缺损，将模型分成两个或更多个模型区段），然后产生具有尺寸和 形状对应于模型段的形状。 这样的组织移植节段可以被组装以形成具有对应于待更换或修复的组织部分的尺寸和形状的组织移植物。

    Device and method for perfusing porous biomaterials with biological liquids
    100.
    发明申请
    Device and method for perfusing porous biomaterials with biological liquids 审中-公开
    用生物液体灌注多孔生物材料的装置和方法

    公开(公告)号：US20160250043A1

    公开(公告)日：2016-09-01

    申请号：US15032300

    申请日：2014-09-11

    申请人： BIOTECK S.P.A.

    发明人： Mauro Fiorini ,  Fabrizio Raimondi

    IPC分类号： A61F2/46 ,  A01N1/02

    CPC分类号： A61F2/4644 ,  A01N1/0247 ,  A61B17/88 ,  A61B17/8833 ,  A61F2002/2835 ,  A61F2002/4648

    摘要： A device for perfusing porous biomaterials with biological liquids includes a tubular body with an axial cavity defining a perfusion chamber for containing a porous biocompatible material, a connector at a distal end of the tubular body for receiving a perfusion liquid, a plunger having a distal end slidably movable in the cavity to withdraw air from the biomaterial, a vent for releasing the air withdrawn from the biomaterial and contained in the chamber, and a filter permitting selective passage of the air contained in the chamber toward the vent, while preventing leakage of the liquid to the outside. An air collector communicates with the chamber and the vent, and a control unit is associated with the plunger and designed to be actuated by the user to control the air flow from the air collector to the vent.A method of perfusing porous biomaterials with biological liquids.

    摘要翻译： 用于用生物液体灌注多孔生物材料的装置包括管状体，其具有限定用于容纳多孔生物相容性材料的灌注腔的轴向空腔，用于容纳灌注液体的管状体远端处的连接器，具有远端 可在空腔中可滑动地移动以从生物材料中抽出空气，用于释放从生物材料排出并容纳在腔室中的空气的排气口，以及允许将容纳在腔室中的空气选择性地通向排气口的过滤器，同时防止 液体到外面。 空气收集器与腔室和通气口连通，并且控制单元与柱塞相关联并被设计成由使用者致动以控制从空气收集器到通风口的空气流。 用生物液体灌注多孔生物材料的方法。