公开(公告)号：US09321866B2

公开(公告)日：2016-04-26

申请号：US14406202

申请日：2013-06-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Pei Yuin Keng ,  Rehana Ismail ,  Ariella Machness ,  Kyoung-Joo Jenny Park

IPC: C08F2/46 ,  C08G61/04 ,  C08F212/14 ,  A61B5/15 ,  B01J19/00 ,  C07B59/00 ,  C07H13/04 ,  C08F236/20 ,  A61B5/151

CPC classification number: C08F212/14 ,  A61B5/1405 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1514 ,  B01D15/363 ,  B01J19/0093 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/328 ,  B01J2219/00831 ,  B01J2219/00844 ,  B01J2219/00846 ,  B01J2219/00905 ,  B01J2219/00918 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2220/82 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0883 ,  C07B59/005 ,  C07H13/04 ,  C08F236/20

Abstract: The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyzes and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection.

Abstract translation: 本公开涉及用于制备用于溶剂交换的聚合物整料的新型多步骤方法，例如在通过微流体芯片的流动上交换和活化氟离子以用于随后的化学合成的方法。 根据本公开的方法包括将这种微流体平台用于快速F18放射合成在高效率流过微流控芯片的流体上，随后进行亲核氟化反应。 还公开了在流过微流体芯片的流动上交换和激活氟离子的各种其它方法。 结合本发明的特征的方法可以适用于任何领域中的任何流过微流体装置的流体，例如放射合成，化学合成，用于环境分析的离子浓度和样品制备，例如浓缩微量分析物以改善下游检测。

公开(公告)号：US09259705B2

公开(公告)日：2016-02-16

申请号：US13698197

申请日：2011-05-26

Applicant: Elena Daniela Lavric ,  Ronan Tanguy

Inventor： Elena Daniela Lavric ,  Ronan Tanguy

IPC: B01D19/00 ,  B01J19/00

CPC classification number: B01J19/0093 ,  B01D19/0042 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905

Abstract: A microreactor device (100) comprises a microcircuit (110) defining a reaction microchamber (112) containing a liquid and reaction medium (114), in which a chemical reaction takes place generating the gas (116), and is characterized in that the device (100) is disposed substantially vertically or inclined, defining an upper part (120) and a lower part (130) of the microchamber, and in that means (150) are provided in the upper part (120) of the said microcircuit for the in situ collection and removal of the gas formed during the reaction.

Abstract translation: 微反应器装置（100）包括限定包含液体的反应微室（110）和反应介质（114）的微电路（110），其中产生化学反应产生气体（116），其特征在于，所述装置 （100）基本上垂直或倾斜地设置，限定微型仓的上部（120）和下部（130），并且在该装置（150）中，所述装置（150）设置在所述微电路的上部（120）中，用于 原位收集和去除在反应过程中形成的气体。

公开(公告)号：US20160038904A1

公开(公告)日：2016-02-11

申请号：US14922210

申请日：2015-10-26

Applicant: Velocys, Inc.

Inventor： Ravi Arora ,  Anna Lee Tonkovich ,  Dongming Qui ,  Laura J. Silva

IPC: B01J19/00

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00898 ,  B01J2219/00905 ,  B01J2219/00907 ,  B01J2219/00918 ,  B01J2219/00921 ,  F28D9/00 ,  F28F3/048 ,  F28F2260/02

Abstract: The invention described herein concerns microchannel apparatus that contains, within the same device, at least one manifold and multiple connecting microchannels that connect with the manifold. For superior heat or mass flux in the device, the volume of the connecting microchannels should exceed the volume of manifold or manifolds. Methods of conducting unit operations in microchannel devices having simultaneous disrupted and non-disrupted flow through microchannels is also described.

Abstract translation: 本文描述的本发明涉及在同一装置内包含与歧管连接的至少一个歧管和多个连接微通道的微通道装置。 为了在器件中获得优异的热或质量通量，连接微通道的体积应超过歧管或歧管的体积。 还描述了在微通道装置中进行单元操作的方法，其具有通过微通道的同时破裂和不中断的流动。

公开(公告)号：US20150251981A1

公开(公告)日：2015-09-10

申请号：US14640465

申请日：2015-03-06

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Inventor： Arockiadoss THEVASAHAYAM

IPC: C07C29/147 ,  C01G49/00 ,  C07C29/60 ,  B01J35/00 ,  B01J37/08 ,  B01J19/08 ,  B01J23/78

CPC classification number: C07C29/147 ,  B01J19/0093 ,  B01J19/087 ,  B01J23/78 ,  B01J35/0033 ,  B01J2219/00792 ,  B01J2219/00799 ,  B01J2219/00835 ,  B01J2219/00846 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01J2219/0093 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/0854 ,  B01J2219/0866 ,  B01J2219/0869 ,  B01J2219/0877 ,  B01J2219/0892 ,  B01J2219/1945 ,  C01G49/0036 ,  C01P2004/64 ,  C01P2006/42 ,  C07C29/00 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/08

Abstract: Systems and methods are disclosed for synthesizing one or more simple alcohols from mixtures including organic acids, water, and a superparamagnetic catalyst exposed to fluctuating magnetic fields under ambient conditions.

Abstract translation: 公开了用于在环境条件下从暴露于波动磁场的有机酸，水和超顺磁催化剂的混合物合成一种或多种简单醇的系统和方法。

公开(公告)号：US20150238918A1

公开(公告)日：2015-08-27

申请号：US14618795

申请日：2015-02-10

Applicant: ABT Molecular Imaging, Inc.

Inventor： Mark Khachaturian ,  Doug Ferguson ,  Aaron McFarland ,  Atilio Anzellotti ,  Clive Brown-Proctor

IPC: B01J19/00 ,  B01J19/08

CPC classification number: A61K51/0491 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  G01N2030/77 ,  G01N2030/8872

Abstract: An automated radiopharmaceutical production and quality control system includes a particle accelerator, a radiopharmaceutical micro-synthesis subsystem, and quality control subsystem. The micro-accelerator of the improved biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in quantities on the order of multiple unit doses, allowing for significant reductions in size, power requirements, and weight when compared to conventional radiopharmaceutical cyclotrons. The radiopharmaceutical micro-synthesis subsystem encompasses a small volume chemical synthesis system comprising a microreactor and/or a microfluidic chip and optimized for synthesizing the radiopharmaceutical in small quantities, allowing for significant reductions in processing time and in the quantity of radioisotope required. The automated quality control subsystem is used to test the composition and characteristics of the radiopharmaceutical to ensure that it is safe to inject.

Abstract translation: 自动放射性药物生产和质量控制系统包括粒子加速器，放射性药物微合成子系统和质量控制子系统。 改进的生物标志物发生器的微加速器被优化用于生产用于合成放射性药物的放射性同位素，其数量在多个单位剂量的数量级上，与常规放射性药物回旋加速器相比，允许显着减小尺寸，功率要求和重量。 放射性药物微合成子系统包括小体积的化学合成系统，其包括微反应器和/或微流体芯片，并被优化用于少量合成放射性药物，允许显着减少处理时间和所需放射性同位素的量。 自动质量控制子系统用于测试放射性药物的组成和特性，以确保注射安全。

公开(公告)号：US09101890B2

公开(公告)日：2015-08-11

申请号：US11443851

申请日：2006-05-25

Applicant: Anna Lee Tonkovich ,  Kai Tod Paul Jarosch ,  Jeffrey D. Marco ,  Bin Yang ,  Sean Patrick Fitzgerald ,  Steven T. Perry ,  Thomas Yuschak ,  Francis P. Daly ,  Haibiao Chen

Inventor： Anna Lee Tonkovich ,  Kai Tod Paul Jarosch ,  Jeffrey D. Marco ,  Bin Yang ,  Sean Patrick Fitzgerald ,  Steven T. Perry ,  Thomas Yuschak ,  Francis P. Daly ,  Haibiao Chen

IPC: C07C2/58 ,  B01F5/06 ,  B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  F28F3/04 ,  F28F13/00

CPC classification number: B01F5/0646 ,  B01F5/0475 ,  B01F5/061 ,  B01F5/0655 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00918 ,  C01B3/38 ,  C01B2203/0233 ,  C01B2203/0833 ,  C01B2203/1041 ,  C01B2203/1082 ,  C01B2203/1241 ,  C07C5/48 ,  C07C45/38 ,  C07C2521/08 ,  C07C2523/28 ,  F28F3/048 ,  F28F13/003 ,  F28F2260/02 ,  Y02P20/582

Abstract: The disclosed technology relates to an apparatus, comprising: at least one microchannel, the microchannel comprising at least one heat transfer wall; a porous thermally conductive support in the microchannel in contact with the heat transfer wall; a catalyst or a sorption medium supported by the porous support; and a heat source and/or heat sink in thermal contact with the heat transfer wall.

公开(公告)号：US20150110684A1

公开(公告)日：2015-04-23

申请号：US14288765

申请日：2014-05-28

Applicant: Rodney J. Allam

Inventor： Rodney J. Allam

IPC: B01J19/00

CPC classification number: C07C29/1518 ,  B01J19/0053 ,  B01J19/245 ,  B01J2219/00051 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/0875 ,  B01J2219/24 ,  C01B3/36 ,  C01B3/382 ,  C01B3/384 ,  C01B13/0248 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/025 ,  C01B2203/04 ,  C01B2203/0495 ,  C01B2203/061 ,  C01B2203/0844 ,  C01B2203/0894 ,  C01B2210/0046 ,  Y02P20/123 ,  Y02P20/124 ,  Y02P20/129 ,  C07C31/04

Abstract: In various implementations, methanol is produced using a (CO+H2) containing synthesis gas produced from a combined POX plus EHTR or a combined ATR plus EHTR at a pressure of 70 bar to 100 bar at the correct stoichiometric composition for methanol synthesis so that no feed gas compressor is required for the feed to the methanol synthesis reactor loop.

Abstract translation: 在各种实施方案中，使用由组合的POX加EHTR或组合的ATR加EHTR产生的（CO + H 2）的合成气在70巴至100巴的压力下以合适的化学计量组成用于甲醇合成来生产甲醇，因此不存在 进料气压缩机是进料到甲醇合成反应器回路所必需的。

公开(公告)号：US08460606B2

公开(公告)日：2013-06-11

申请号：US11628335

申请日：2005-06-02

Applicant: Jose Prieto Barranco ,  Consuelo Goberna Selma

Inventor： Jose Prieto Barranco ,  Consuelo Goberna Selma

IPC: G01N33/00 ,  G01N31/00 ,  G01N31/10 ,  B01J10/00 ,  G01N31/12 ,  G01N7/00 ,  G01N30/02 ,  B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00423 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00747 ,  B01J2219/00788 ,  B01J2219/00835 ,  B01J2219/00905 ,  B01J2219/00959 ,  B01J2219/00986 ,  G01N31/10

Abstract: The invention relates to a reaction device which is used to study the behavior of a catalyst in the presence of reactants. The inventive device includes: various different mass flow regulators, which are used to supply a known controlled stream of gases, a pump which supplies the system with liquid reactants from a container, a hot box, wherein there have been placed a supply current evaporator and preheater, a valve which can be used to select the process path, a reactor into which the catalyst is introduced inside a furnace, a system which can be used to separate the liquid and gaseous products by cold condensation under pressure and which controls the pressure in the line of output gases, and a system for controlling the level in the decantation operation, the system being automated and computerized.

Abstract translation: 本发明涉及一种用于研究催化剂在反应物存在下的行为的反应装置。 本发明的装置包括：各种不同的质量流量调节器，其用于提供已知的受控气流，从容器向系统提供液体反应物的泵，热箱，其中已经放置了供应电流蒸发器， 预热器，可用于选择工艺路径的阀门，将催化剂引入炉内的反应器，可用于在压力下通过冷凝而分离液体和气体产物并控制压力的系统 输出气体管线和用于控制倾析操作中的水平的系统，该系统被自动化和计算机化。

公开(公告)号：US20130055896A1

公开(公告)日：2013-03-07

申请号：US13698197

申请日：2011-05-26

Applicant: Elena Daniela Lavric ,  Ronan Tanguy

Inventor： Elena Daniela Lavric ,  Ronan Tanguy

IPC: B01J7/00 ,  B01D19/00

CPC classification number: B01J19/0093 ,  B01D19/0042 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905

Abstract: A microreactor device (100) comprises a microcircuit (110) defining a reaction microchamber (112) containing a liquid and reaction medium (114), in which a chemical reaction takes place generating the gas (116), and is characterized in that the device (100) is disposed substantially vertically or inclined, defining an upper part (120) and a lower part (130) of the microchamber, and in that means (150) are provided in the upper part (120) of the said microcircuit for the in situ collection and removal of the gas formed during the reaction.

Abstract translation: 微反应器装置（100）包括限定包含液体的反应微室（110）和反应介质（114）的微电路（110），其中产生化学反应产生气体（116），其特征在于，所述装置 （100）基本上垂直或倾斜地设置，限定微型仓的上部（120）和下部（130），并且在该装置（150）中，所述装置（150）设置在所述微电路的上部（120）中，用于 原位收集和去除在反应过程中形成的气体。

公开(公告)号：US07820445B2

公开(公告)日：2010-10-26

申请号：US10830710

申请日：2004-04-22

Applicant: Kai Jarosch ,  Anna Lee Tonkovich ,  David J. Hesse ,  Eric Daymo ,  Steven T. Perry ,  Laura J. Silva

Inventor： Kai Jarosch ,  Anna Lee Tonkovich ,  David J. Hesse ,  Eric Daymo ,  Steven T. Perry ,  Laura J. Silva

IPC: G01N31/10

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905

Abstract: This invention describes gas-solid, liquid-solid and gas-solid-liquid processes in microchannels devices including such processes as heterogeneous catalysis, particle formation, particle attrition, particle separation and adsorption or desorption of selected species. Various processes can be enhanced by the unique properties of microchannels such as the predominance of laminar flow, high rates of shear, high rates of heat transfer and high rates of mass transfer. Also encompassed by this invention are methods for the introduction to and removal from microchannels of particle containing fluid streams.

Abstract translation: 本发明描述了微通道装置中的气固，液固和气固液体方法，包括异种催化，颗粒形成，颗粒磨耗，颗粒分离和所选物种的吸附或解吸等过程。 可以通过微通道的独特性质来提高各种工艺，例如层流的优势，高剪切速率，高传热速率和高传质速率。 本发明还包括用于引入和除去含微粒流体物流的微通道的方法。